KEGG   COMPOUND: C00410
Entry
C00410                      Compound                               
Name
Progesterone;
4-Pregnene-3,20-dione
Formula
C21H30O2
Exact mass
314.2246
Mol weight
314.4617
Structure
Remark
Same as: D00066
Reaction
Pathway
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
map04080  Neuroactive ligand-receptor interaction
map04114  Oocyte meiosis
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04917  Prolactin signaling pathway
map04925  Aldosterone synthesis and secretion
map04927  Cortisol synthesis and secretion
map04934  Cushing syndrome
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05215  Prostate cancer
map05224  Breast cancer
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Network
nt06019  Steroid hormone biosynthesis
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06227  Nuclear receptor signaling (cancer)
nt06272  Prostate cancer
Enzyme
1.1.1.145       1.1.1.149       1.3.1.3         1.3.1.22        
1.3.99.6        1.14.13.54      1.14.14.16      1.14.14.19      
1.14.15.4       1.14.15.8       1.14.99.4       1.14.99.14      
5.3.3.1
Brite
Compounds with biological roles [BR:br08001]
 Steroids
  21-Carbon atoms
   Pregnane derivatives
    C00410  Progesterone
 Hormones and transmitters
  Steroid hormones
   Progestagens
    C00410  Progesterone
Lipids [BR:br08002]
 ST  Sterol lipids
  ST02 Steroids
   ST0203 C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives
    C00410  Progesterone
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03D PROGESTOGENS
    G03DA Pregnen (4) derivatives
     G03DA04 Progesterone
      D00066  Progesterone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Progesterone
    D00066  Progesterone (JP18/USP/INN)
 Infertility Agents
  Progesterone
   D00066  Progesterone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2477  Progesterones
     D00066  Progesterone (JP18/USP/INN)
Animal drugs in Japan [BR:br08331]
 94  Agents for breeding
  941  Hormone preparations (except posterior-pituitary hormone and preparations)
   9415  Luteinizing hormone and preparations
    C00410  Progesterone
Drug groups [BR:br08330]
 Hormonal agent
  DG02004  Progesterone
   D00066  Progesterone
  DG01666  Progesterone receptor agonist
   D00066  Progesterone
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D00066  Progesterone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00066  Progesterone
Drug classes [BR:br08332]
 Endocrine and hormonal agent
  DG02004  Progesterone
   D00066  Progesterone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D00066  Progesterone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00066  Progesterone
  D00066  Progesterone injection
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00066
Other DBs
CAS: 57-83-0
PubChem: 3700
ChEBI: 17026
LIPIDMAPS: LMST02030159
KNApSAcK: C00034649
PDB-CCD: STR[PDBj]
3DMET: B01238
NIKKAJI: J2.329I
LinkDB
KCF data

ATOM        23
            1   C1y C    23.0350  -18.9936
            2   C1y C    24.2088  -19.6769
            3   C1z C    21.8554  -19.6827
            4   C1x C    23.0233  -17.6271
            5   C1y C    25.4002  -18.9819
            6   C1x C    24.1913  -21.0784
            7   C2y C    21.8554  -21.0375
            8   C1x C    20.6873  -19.0112
            9   C1a C    21.8437  -18.2754
            10  C1x C    24.2030  -16.9322
            11  C1z C    25.4060  -17.6097
            12  C1x C    27.7653  -18.9936
            13  C1x C    23.0409  -21.7092
            14  C2x C    20.6873  -21.7150
            15  C1x C    19.5194  -19.6827
            16  C1y C    26.5974  -16.9263
            17  C1a C    25.3943  -16.2081
            18  C1x C    27.7712  -17.6213
            19  C5x C    19.5194  -21.0375
            20  C5a C    26.6032  -15.5948
            21  O5x O    18.3690  -21.6975
            22  C1a C    25.3885  -14.8823
            23  O5a O    27.8121  -14.8882
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 2
            14    8  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1
            18   14  19 1
            19   16  20 1 #Up
            20   19  21 2
            21   20  22 1
            22   20  23 2
            23    7  13 1
            24   10  11 1
            25   15  19 1
            26   16  18 1

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