| Entry |
|
|---|
| Name |
Modafinil (JAN/USP/INN);
Provigil (TN) |
|---|
| Product |
|
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| Generic |
MODAFINIL (Alembic Pharmaceuticals Limited), MODAFINIL (Alembic Pharmaceuticals), MODAFINIL (American Health Packaging), MODAFINIL (Aphena Pharma Solutions - Tennessee), MODAFINIL (Aphena Pharma Solutions - Tennessee), MODAFINIL (Apotex Corp.), MODAFINIL (Aurobindo Pharma Limited), MODAFINIL (AvPAK), MODAFINIL (Bionpharma), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (CIMA LABS), MODAFINIL (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), MODAFINIL (Major Pharmaceuticals), MODAFINIL (Major Pharmaceuticals), MODAFINIL (NuCare Pharmaceuticals), MODAFINIL (Preferred Pharmaceuticals), MODAFINIL (Preferred Pharmaceuticals), MODAFINIL (Proficient Rx LP), MODAFINIL (Proficient Rx LP), MODAFINIL (Rising Health), MODAFINIL (Viona Pharmaceuticals), MODAFINIL (Zydus Lifesciences Limited) |
|---|
| Formula |
C15H15NO2S
|
|---|
| Exact mass |
273.0823
|
|---|
| Mol weight |
273.3501
|
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| Structure |
|
|---|
| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01971 Agents for narcolepsy
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG01933 CYP2C19 inhibitor
Metabolizing enzyme inducer
DG01637 CYP1A2 inducer
DG02891 CYP2B6 inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
|
|---|
| Remark |
| Therapeutic category: | 1179 |
|
|---|
| Efficacy |
Stimulant (central) |
|---|
| Disease |
|
|---|
| Comment |
Treatment of narcolepsy and hypersomnia
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
CYP inhibition: CYP2C9 [HSA: 1559], CYP2C19 [HSA: 1557]
CYP induction: CYP1A2 [HSA: 1544], CYP2B6 [HSA: 1555], CYP3A4 [HSA: 1576]
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
N06BA Centrally acting sympathomimetics
N06BA07 Modafinil
D01832 Modafinil (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Sleep Disorder Agents
Wakefulness Promoting Agents
Modafinil
D01832 Modafinil (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D01832 Modafinil (JAN/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01971 Agents for narcolepsy
D01832 Modafinil
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D01832 Modafinil
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
D01832 Modafinil
DG01933 CYP2C19 inhibitor
D01832 Modafinil
Metabolizing enzyme inducer
DG01637 CYP1A2 inducer
D01832 Modafinil
DG02891 CYP2B6 inducer
D01832 Modafinil
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
D01832 Modafinil
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01832
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01832
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D01832
Narcotics and psychotropics in Japan [br08308.html]
Psychotropics by Cabinet order Article 3 (78 substances)
D01832
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 19
1 C8x C 21.4292 -18.4524
2 C8x C 21.4292 -19.8539
3 C8x C 22.6459 -20.5546
4 C8x C 23.8554 -19.8539
5 C8y C 23.8554 -18.4524
6 C8x C 22.6459 -17.7516
7 C1c C 25.0604 -17.7516
8 C8y C 26.2708 -18.4524
9 C8x C 26.2691 -19.8510
10 C8x C 27.4794 -20.5517
11 C8x C 28.6914 -19.8539
12 C8x C 28.6931 -18.4552
13 C8x C 27.4828 -17.7545
14 S4a S 25.0590 -16.3501
15 C1b C 26.2721 -15.6482
16 O3c O 23.8447 -15.6505
17 C5a C 26.2708 -14.2467
18 N1a N 27.4839 -13.5447
19 O5a O 25.0563 -13.5471
BOND 20
1 4 5 1
2 5 6 2
3 6 1 1
4 8 9 2
5 9 10 1
6 10 11 2
7 11 12 1
8 12 13 2
9 13 8 1
10 7 14 1
11 5 7 1
12 14 15 1
13 1 2 2
14 14 16 2
15 7 8 1
16 15 17 1
17 2 3 1
18 17 18 1
19 3 4 2
20 17 19 2
|
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