KEGG   ENZYME: 1.1.1.104
Entry
EC 1.1.1.104                Enzyme                                 
Name
4-oxoproline reductase;
cis-hydroxy-L-proline oxidase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cis-4-hydroxy-L-proline:NAD+ oxidoreductase (4-oxo-L-proline forming)
Reaction(IUBMB)
cis-4-hydroxy-L-proline + NAD+ = 4-oxo-L-proline + NADH + H+ [RN:R07146]
Reaction(KEGG)
R07146
Substrate
cis-4-hydroxy-L-proline [CPD:C01015];
NAD+ [CPD:C00003]
Product
4-oxo-L-proline [CPD:C01877];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, isolated from animals, is specific for 4-oxo-L-proline and cis-4-hydroxy-L-proline. It has no activity with trans-4-hydroxy-L-proline.
History
EC 1.1.1.104 created 1972, modified 2022
Orthology
K25939  4-oxoproline reductase
Genes
HSA56898(BDH2)
PTR461412(BDH2)
PPS100983278(BDH2) 100991105
GGO101124932(BDH2)
PON100433252(BDH2)
NLE100606381(BDH2)
HMH116482311(BDH2)
MCC711108(BDH2)
MCF102115136(BDH2)
MTHB126955399
MNI105486327(BDH2)
CSAB103236057(BDH2)
CATY105571382(BDH2)
PANU101001872(BDH2)
TGE112624440(BDH2)
MLEU105548323(BDH2)
RRO104662323(BDH2)
RBB108532803(BDH2)
TFN117085724(BDH2)
PTEH111547981(BDH2)
CANG105512685(BDH2)
CJC100409335(BDH2)
SBQ101031990(BDH2)
CIMI108289246(BDH2)
CSYR103261987(BDH2)
MMUR105874809
LCAT123627214(BDH2)
PCOQ105819187(BDH2)
OGA100953275(BDH2)
MMU69772(Bdh2)
MCAL110291296(Bdh2)
MPAH110320466(Bdh2)
RNO295458(Bdh2)
MCOC116093815(Bdh2)
ANU117707041(Bdh2)
MUN110558605(Bdh2)
CGE100766065(Bdh2)
MAUA101840581(Bdh2)
PROB127222954(Bdh2)
PLEU114683120(Bdh2)
MORG121450280(Bdh2)
MFOT126511172
AAMP119800931(Bdh2)
NGI103728028
HGL101723446(Bdh2)
CPOC100717546(Bdh2)
CCAN109697670(Bdh2)
DORD105991162(Bdh2)
DSP122127114(Bdh2)
PLOP125341447(Bdh2)
NCAR124995002
MMMA107141358(Bdh2)
OCU100344675
OPI101518015(BDH2)
TUP102488670(BDH2)
GVR103597116(BDH2)
CFA100855513(BDH2)
CLUD112644527(BDH2)
VVP112908370(BDH2)
VLG121492420(BDH2)
NPO129521255(BDH2)
AML105235247(BDH2)
UMR103677958(BDH2)
UAH113263090
UAR123789044(BDH2)
ELK111154403
LLV125093236
MPUF101676172(BDH2)
MNP132014159(BDH2)
MLK131829742(BDH2)
NVS122889320(BDH2)
ORO101375469(BDH2)
EJU114199331(BDH2)
ZCA113924582(BDH2)
MLX118027058(BDH2)
NSU110572094(BDH2)
LWW102733565(BDH2)
FCA101094095(BDH2)
PYU121031772(BDH2)
PCOO112858421(BDH2)
PBG122477934(BDH2)
LRUF124521009
PTG102961489(BDH2)
PPAD109247548(BDH2)
PUC125922975
AJU106984710
HHV120222821(BDH2)
BTA515321(BDH2)
BOM102285888(BDH2)
BIU109560287(BDH2)
BBUB102397581(BDH2)
BBIS104994628(BDH2)
CHX102173540(BDH2)
OAS101106011(BDH2)
BTAX128049630(BDH2)
ODA120861868(BDH2)
CCAD122422184(BDH2)
MBEZ129561859(BDH2)
SSC100522692(BDH2)
CFR102514100(BDH2)
CBAI105067921(BDH2)
CDK105089568(BDH2)
VPC102529637(BDH2)
BACU103012561(BDH2)
LVE103082336(BDH2)
OOR101273365(BDH2)
DLE111171467(BDH2)
PCAD102977741(BDH2)
PSIU116754666(BDH2)
NASI112397590(BDH2)
ECB100068172(BDH2)
EPZ103564400(BDH2)
EAI106847258(BDH2)
MYB102252169(BDH2)
MYD102768959(BDH2)
MMYO118671929(BDH2)
MLF102437720(BDH2)
MNA107545533(BDH2)
PKL118703342(BDH2)
EFUS103293901(BDH2)
HAI109372546(BDH2)
DRO112317840(BDH2)
SHON118977176(BDH2)
AJM119065763(BDH2)
PDIC114492562(BDH2)
PHAS123806819(BDH2)
MMF118632942(BDH2)
RFQ117022538(BDH2)
PPAM129085429(BDH2)
PALE102882829(BDH2)
PGIG120591103(BDH2)
PVP105293023(BDH2)
RAY107517893(BDH2)
MJV108397079(BDH2)
TOD119243674(BDH2)
SARA101544968(BDH2)
LAV100657244 100663603 104845941
TMU101360504
ETF101641200(BDH2)
DNM101436882(BDH2)
MDO100012027(BDH2)
GAS123251675(BDH2)
SHR100931698(BDH2)
AFZ127539686
PCW110223063(BDH2)
OAA100076108(BDH2)
GGA422715(BDH2)
PCOC116238883(BDH2)
MGP100547472(BDH2)
CJO107313665(BDH2)
TPAI128080685(BDH2)
LMUT125692698(BDH2)
NMEL110398432(BDH2)
APLA101789473(BDH2)
ACYG106045316(BDH2)
CATA118243587(BDH2)
AFUL116488698(BDH2)
TGU100220657(BDH2)
LSR110471156(BDH2)
SCAN103826022(BDH2)
PMOA120498824(BDH2)
OTC121346590(BDH2)
PRUF121362639(BDH2)
GFR102037474(BDH2) 102041424
FAB101816179(BDH2)
OMA130252131(BDH2)
PHI102107284(BDH2)
PMAJ107203282(BDH2)
CCAE111928329(BDH2)
CCW104697102(BDH2)
CBRC103617317(BDH2)
ETL114068170(BDH2)
ZAB102070466(BDH2)
SVG106852547(BDH2)
MMEA130584263(BDH2)
HRT120753465(BDH2)
FPG101919488(BDH2)
FCH102047342(BDH2)
EGZ104127819(BDH2)
NNI104021180(BDH2)
PCRI104024939(BDH2)
PLET104622204(BDH2)
PCAO104044892(BDH2)
ACUN113479844(BDH2)
TALA104363919(BDH2)
PADL103919526(BDH2)
AFOR103894221(BDH2)
ACHC115341605(BDH2)
HALD104319900(BDH2)
HLE104827795(BDH2)
AGEN126044684
GCL127015676
CCRI104155114(BDH2)
CSTI104562628(BDH2)
CMAC104487037(BDH2)
MUI104543089(BDH2)
BREG104637206(BDH2)
FGA104073337(BDH2)
GSTE104263200(BDH2)
LDI104340737(BDH2)
MNB103770970(BDH2)
OHA104331651(BDH2)
NNT104406712(BDH2)
SHAB115610761(BDH2)
DPUB104307761(BDH2)
ACAR104521817(BDH2)
CPEA104393649(BDH2)
AVIT104268756(BDH2)
CVF104286859(BDH2)
RTD128909872(BDH2)
CUCA104068734(BDH2)
TEO104375932(BDH2)
BRHI104496964(BDH2)
AAM106492005(BDH2)
AROW112972195(BDH2)
NPD112957304(BDH2)
TGT104570078(BDH2)
DNE112988401(BDH2)
SCAM104153448(BDH2)
ASN102368468(BDH2)
AMJ102559265(BDH2)
CPOO109322261(BDH2)
GGN109303808(BDH2)
PSS102454817(BDH2)
CMY102945609(BDH2)
CCAY125635592(BDH2)
DCC119855234(BDH2)
CPIC101944622(BDH2)
TST117878287(BDH2)
CABI116833055(BDH2)
MRV120407167(BDH2)
ASAO132776954(BDH2)
PVT110080462(BDH2)
SUND121931074(BDH2)
PBI103051101(BDH2)
PMUR107299079(BDH2)
CTIG120311330(BDH2)
TSR106547674(BDH2)
PGUT117679895(BDH2)
APRI131203231(BDH2)
PTEX113434814(BDH2)
NSS113415352(BDH2)
VKO123022796(BDH2)
PMUA114604266(BDH2)
PRAF128421308(BDH2)
ZVI118084118(BDH2)
HCG128325671(BDH2)
GJA107105758(BDH2)
STOW125440366(BDH2)
EMC129337066(BDH2)
XLA734851(bdh2.L)
XTR100485678(bdh2)
NPR108789056(BDH2)
RTEM120918337(BDH2)
BBUF120989864(BDH2)
BGAR122924923 122925024(BDH2)
MUO115461155(BDH2)
GSH117365889(BDH2)
DRE550507(bdh2)
SRX107746975
SANH107664555(bdh2) 107674194
SGH107552725 107556803(bdh2)
CAUA113070029(bdh2)
CGIB128017349
PTET122347331(bdh2)
LROH127166163(bdh2)
OMC131546965(bdh2)
PPRM120491463(bdh2)
RKG130072007(bdh2)
MAMB125272239(bdh2)
CIDE127514984
MASI127444326 127444601
TROS130552683(bdh2)
TDW130408083(bdh2)
MANU129444258 129444263
IPU100528506(bdh2)
IFU128604392(bdh2)
PHYP113545738(bdh2)
SMEO124381642(bdh2)
TFD113649963(bdh2)
TVC132841666(bdh2)
AMEX103045499(bdh2)
CMAO118816624(bdh2)
EEE113584734(bdh2)
CHAR105908421(bdh2)
TRU101071289(bdh2)
TFS130526712(bdh2)
TNGGSTEN00019991G001
LCO104928192(bdh2)
NCC104953003(bdh2)
TBEN117474622(bdh2)
CGOB115008071(bdh2)
PGEO117443206(bdh2)
GACU117546273(bdh2)
ELY117255325(bdh2)
EFO125885571(bdh2)
PLEP121942516(bdh2)
SLUC116034251(bdh2)
ECRA117955710(bdh2)
ESP116699620(bdh2)
PFLV114571634(bdh2)
GAT120825214(bdh2)
PPUG119218229(bdh2)
AFB129095599(bdh2)
CLUM117738590(bdh2)
MSAM119899003(bdh2)
SCHU122873007(bdh2)
CUD121508006(bdh2)
ALAT119020122(bdh2)
MZE101470397(bdh2)
ONL100710170(bdh2)
OAU116331396(bdh2)
OLA101167770(bdh2)
OML112157228(bdh2)
XMA102235326(bdh2)
XCO114144997(bdh2)
XHE116720380(bdh2)
PRET103467421(bdh2)
PFOR103137869(bdh2)
PLAI106949932(bdh2)
PMEI106928939(bdh2)
GAF122830144(bdh2)
PPRL129366985(bdh2)
CVG107099491(bdh2)
CTUL119771880(bdh2)
GMU124867879(bdh2)
NFU107375234(bdh2)
KMR108234183(bdh2)
ALIM106517154(bdh2)
NWH119408091(bdh2)
AOCE111567771(bdh2)
MCEP125003952(bdh2)
CSEM103383843(bdh2)
POV109637768(bdh2)
SSEN122771242(bdh2)
HHIP117760466(bdh2)
HSP118116883(bdh2)
LCF108896599
SDU111231411(bdh2)
SLAL111664022(bdh2)
XGL120800247(bdh2)
HCQ109519887(bdh2)
SSCV125968664
SBIA133506333(bdh2)
PEE133403889(bdh2)
PTAO133477486(bdh2)
BPEC110165411(bdh2)
MALB109961293(bdh2)
BSPL114852743(bdh2)
SJO128371035(bdh2)
SASA100196895(bdh2)
STRU115208458(bdh2)
OTW112266393(bdh2)
OMY110493817(bdh2)
OGO124002857(bdh2)
ONE115142694(bdh2)
OKI109890746(bdh2)
OKE118389070(bdh2)
SALP111961039(bdh2)
SNH120064887(bdh2)
CCLU121572331 123483404
ELS105027153(bdh2)
SFM108924416(bdh2)
PKI111837255(bdh2)
AANG118227575(bdh2)
LOC102683653(bdh2)
PSPA121321903(bdh2)
ARUT117420838(bdh2)
PSEX120532818(bdh2)
LCM102353326(BDH2)
CMK103177630(bdh2)
RTP109925787(bdh2)
HOC132833432(bdh2)
LERI129702228(bdh2)
PMRN116947921(BDH2)
LRJ133341235(BDH2)
BFO118423115
BBEL109464664 109479591 109481035
CIN100183445
SCLV120342253
SPU586067
LPIC129259193 129259738
APLC110974490
AJC117122464 117125528
FCD110860577
PVM113812913
PJA122255204
PCHN125046742
PMOO119590988
PCLA123767945
CQD128686436
PTRU123516573 123516684
ESN126999177 127000051
HAZT108670283
LSM121123954
TCF131883323
LGILOTGIDRAFT_161109
PVUL126811241
PCAN112566254
BGT106076718
GAE121370584
HRF124140334
HRJ124287566
CRG117691254
CVN111103968 111104091
CANU128183213
OED125674146
MYI110450719
PMAX117328122
MCAF127725411
MMER123552255
RPHI132715623
DPOL127850354
OBI106879984
OSN115222774
LAK106181829
EPA110240260
ATEN116290964
ADF107349724
AMIL114957072
PDAM113671958
SPIS111324257
DGT114537580
XEN124434055
AQU100640865
 » show all
Reference
1  [PMID:13914427]
  Authors
SMITH TE, MITOMA C.
  Title
Partial purification and some properties of 4-ketoproline reductase.
  Journal
J Biol Chem 237:1177-80 (1962)
Reference
2  [PMID:35150746]
  Authors
Kwiatkowski S, Bozko M, Zarod M, Witecka A, Kocdemir K, Jagielski AK, Drozak J.
  Title
Recharacterization of the mammalian cytosolic type 2 (R)-beta-hydroxybutyrate dehydrogenase as 4-oxo-l-proline reductase (EC 1.1.1.104).
  Journal
J Biol Chem 298:101708 (2022)
DOI:10.1016/j.jbc.2022.101708
  Sequence
[rno:295458]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.104
IUBMB Enzyme Nomenclature: 1.1.1.104
ExPASy - ENZYME nomenclature database: 1.1.1.104
BRENDA, the Enzyme Database: 1.1.1.104
CAS: 37250-37-6
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