KEGG ENZYME: 1.1.1.166

ENZYME: 1.1.1.166

Entry

EC 1.1.1.166                Enzyme

Name

hydroxycyclohexanecarboxylate dehydrogenase;
dihydroxycyclohexanecarboxylate dehydrogenase;
(-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD+ oxidoreductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase

Reaction(IUBMB)

(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD+ = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + NADH + H+ [RN:R05315]

Reaction(KEGG)

R05315

Substrate

(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate [CPD:C04687];
NAD+ [CPD:C00003]

Product

(1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate [CPD:C04670];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Acts on hydroxycyclohexanecarboxylates that have an equatorial carboxy group at C-1, an axial hydroxy group at C-3 and an equatorial hydroxy or carbonyl group at C-4, including (-)-quinate and (-)-shikimate.

History

EC 1.1.1.166 created 1976

Reference

1 [PMID:4375976]

Authors

Whiting GC, Coggins RA.

Title

A new nicotinamide-adenine dinucleotide-dependent hydroaromatic dehydrogenase of Lactobacillus plantarum and its role in formation of (minus)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate.

Journal

Biochem J 141:35-42 (1974)
DOI:10.1042/bj1410035

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.166

IUBMB Enzyme Nomenclature:

1.1.1.166

ExPASy - ENZYME nomenclature database:

1.1.1.166

BRENDA, the Enzyme Database:

1.1.1.166

CAS:	55467-53-3

LinkDB

DBGET integrated database retrieval system