Entry
Name
7beta-hydroxysteroid dehydrogenase (NADP+);
NADP+-dependent 7beta-hydroxysteroid dehydrogenase;
7beta-hydroxysteroid dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
7beta-hydroxysteroid:NADP+ 7-oxidoreductase
Reaction(IUBMB)
a 7beta-hydroxysteroid + NADP+ = a 7-oxosteroid + NADPH + H+ [RN:
R03753 ]
Reaction(KEGG)
Substrate
Product
Comment
Catalyses the oxidation of the 7beta-hydroxy group of bile acids such as ursodeoxycholate.
History
EC 1.1.1.201 created 1984
Pathway
ec00121 Secondary bile acid biosynthesis
Orthology
K23231 7beta-hydroxysteroid dehydrogenase (NADP+)
Genes
PCAT : Pcatena_10380(fabG_2)
Taxonomy
Reference
Authors
Hirano S, Masuda N.
Title
Characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens.
Journal
Reference
Authors
MacDonald IA, Roach PD.
Title
Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum.
Journal
Reference
Authors
MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV.
Title
Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.201
LinkDB
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