KEGG   ENZYME: 1.1.1.226
Entry
EC 1.1.1.226                Enzyme                                 
Name
trans-4-hydroxycyclohexanecarboxylate dehydrogenase;
4-hydroxycyclohexanecarboxylate dehydrogenase (ambiguous);
chcB1 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
trans-4-hydroxycyclohexane-1-carboxylate:NAD+ 4-oxidoreductase
Reaction(IUBMB)
trans-4-hydroxycyclohexane-1-carboxylate + NAD+ = 4-oxocyclohexane-1-carboxylate + NADH + H+ [RN:R04307]
Reaction(KEGG)
R04307
Substrate
trans-4-hydroxycyclohexane-1-carboxylate [CPD:C04404];
NAD+ [CPD:C00003]
Product
4-oxocyclohexane-1-carboxylate [CPD:C03767];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from Corynebacterium cyclohexanicum is highly specific for the trans-4-hydroxy derivative. cf. EC 1.1.1.438, cis-4-hydroxycyclohexanecarboxylate dehydrogenase.
History
EC 1.1.1.226 created 1990, modified 2024
Reference
1  [PMID:3292236]
  Authors
Obata H, Uebayasi M, Kaneda T.
  Title
Purification and properties of 4-hydroxycyclohexanecarboxylate dehydrogenase from Corynebacterium cyclohexanicum.
  Journal
Eur J Biochem 174:451-8 (1988)
DOI:10.1111/j.1432-1033.1988.tb14119.x
Reference
2  [PMID:34583900]
  Authors
Yamamoto T, Hasegawa Y, Lau PCK, Iwaki H
  Title
Identification and characterization of a chc gene cluster responsible for the aromatization pathway of cyclohexanecarboxylate degradation in Sinomonas cyclohexanicum ATCC 51369.
  Journal
J Biosci Bioeng 132:621-629 (2021)
DOI:10.1016/j.jbiosc.2021.08.013
  Sequence
[ccyc:SCMU_09900]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.226
IUBMB Enzyme Nomenclature: 1.1.1.226
ExPASy - ENZYME nomenclature database: 1.1.1.226
BRENDA, the Enzyme Database: 1.1.1.226
CAS: 67272-36-0
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