| Entry |
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| Name |
serine 3-dehydrogenase (NADP+);
serine 3-dehydrogenase
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
L-serine:NADP+ 3-oxidoreductase
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| Reaction(IUBMB) |
L-serine + NADP+ = 2-aminoacetaldehyde + CO2 + NADPH + H+ (overall reaction) [RN: R10984];
(1a) L-serine + NADP+ = 2-aminomalonate semialdehyde + NADPH + H+ [RN: R06126];
(1b) 2-aminomalonate semialdehyde = 2-aminoacetaldehyde + CO2 (spontaneous) [RN: R06830]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
NAD+ cannot replace NADP+ [cf. EC 1.1.1.387, serine 3-dehydrogenase (NAD+)].
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| History |
EC 1.1.1.276 created 2003, modified 2015
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| Orthology |
| K05886 | serine 3-dehydrogenase (NADP+) |
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| Genes |
| XPH: | XppCFBP6546_14805(XppCFBP6546P_14805) |
| SYB: | TZ53_14220 TZ53_18295 |
| SBD: | ATN00_06455 ATN00_17655 |
| SPHT: | K426_15085 K426_24024 |
| SUFL: | FIL70_00745 FIL70_06665 |
| AZM: | DM194_19005 DM194_21170 |
| AZS: | E6C72_15875 E6C72_24720 |
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| Reference |
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| Authors |
Fujisawa H, Nagata S, Chowdhury EK, Matsumoto M, Misono H |
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| Title |
Cloning and sequencing of the serine dehydrogenase gene from Agrobacterium tumefaciens. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Chowdhury EK, Higuchi K, Nagata S, Misono H |
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| Title |
A novel NADP(+)-dependent serine dehydrogenase from Agrobacterium tumefaciens. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.1.1.276 |
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| LinkDB |
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