KEGG ENZYME: 1.1.1.279

ENZYME: 1.1.1.279

Entry

EC 1.1.1.279                Enzyme

Name

(R)-3-hydroxyacid-ester dehydrogenase;
3-oxo ester (R)-reductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase

Reaction(IUBMB)

ethyl (R)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + NADPH + H+ [RN:R04105]

Reaction(KEGG)

R04105

Substrate

ethyl (R)-3-hydroxyhexanoate [CPD:C03864];
NADP+ [CPD:C00006]

Product

ethyl 3-oxohexanoate [CPD:C02975];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Also acts on ethyl (R)-3-oxobutanoate and some other (R)-3-hydroxy acid esters. The (R)- symbol is allotted on the assumption that no substituents change the order of priority from O-3 > C-2 > C-4. A subunit of yeast fatty acid synthase EC 2.3.1.86, fatty-acyl-CoA synthase system. cf. EC 1.1.1.280, (S)-3-hydroxyacid ester dehydrogenase.

History

EC 1.1.1.279 created 1990 as EC 1.2.1.55, transferred 2003 to EC 1.1.1.279, modified 2018

Reference

1 [PMID:3280313]

Authors

Heidlas J, Engel KH, Tressl R.

Title

Purification and characterization of two oxidoreductases involved in the enantioselective reduction of 3-oxo, 4-oxo and 5-oxo esters in baker's yeast.

Journal

Eur J Biochem 172:633-9 (1988)
DOI:10.1111/j.1432-1033.1988.tb13936.x

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.279

IUBMB Enzyme Nomenclature:

1.1.1.279

ExPASy - ENZYME nomenclature database:

1.1.1.279

BRENDA, the Enzyme Database:

1.1.1.279

CAS:	114705-02-1

LinkDB

DBGET integrated database retrieval system