Entry
Name
S-(hydroxymethyl)mycothiol dehydrogenase;
NAD/factor-dependent formaldehyde dehydrogenase;
mycothiol-dependent formaldehyde dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
S-(hydroxymethyl)mycothiol:NAD+ oxidoreductase
Reaction(IUBMB)
S-(hydroxymethyl)mycothiol + NAD+ = S-formylmycothiol + NADH + H+ [RN:
R09129 ]
Reaction(KEGG)
Substrate
Product
Comment
S-hydroxymethylmycothiol is believed to form spontaneously from formaldehyde and mycothiol. This enzyme oxidizes the product of this spontaneous reaction to S-formylmycothiol, in a reaction that is analogous to EC
1.1.1.284 , S-(hydroxymethyl)glutathione dehydrogenase.
History
EC 1.1.1.306 created 2010 as EC 1.2.1.66, transferred 2010 to EC 1.1.1.306
Orthology
K00153 S-(hydroxymethyl)mycothiol dehydrogenase
Genes
MSA : Mycsm_03758 Mycsm_03994 Mycsm_06630
MMAE : MMARE11_32510(adhE2)
MDX : BTO20_12995 BTO20_34000
MSHG : MSG_02027 MSG_03185
MFJ : MFLOJ_00330 MFLOJ_17790 MFLOJ_17800 MFLOJ_23770(mscR)
MSTO : MSTO_00980 MSTO_13580
MHEK : JMUB5695_02072(mscR)
MPAA : MKK62_10000 MKK62_18140
MWU : PT015_00720 PT015_07530
MTHN : 4412656_01773(adhE2)
MCHT : MCHIJ_09240 MCHIJ_33480
MAUU : NCTC10437_03524(adhE2)
MHEV : MHEL_01510 MHEL_60410
MAUB : MAUB_20880 MAUB_50530
MPHU : MPHO_14210 MPHO_18890 MPHO_51060
MMUC : C1S78_008965 C1S78_022405
MMAT : MMAGJ_18400 MMAGJ_50850 MMAGJ_73720
MFG : K6L26_13035 K6L26_29450
MFLV : NCTC10271_01888(adhE2)
MSEN : K3U95_02260 K3U95_16090
MTER : 4434518_01553(adhE2)
CDX : CDES_00575 CDES_01670
CMIN : NCTC10288_02284(mscR)
CCYC : SCMU_09080 SCMU_22400
NBR : O3I_018380 O3I_031325 O3I_033790
NSL : BOX37_07385 BOX37_20055
NOZ : DMB37_02165 DMB37_10245
NAH : F5544_24885 F5544_29545
NTC : KHQ06_20280 KHQ06_24290
NHU : H0264_10925 H0264_19190 H0264_22200
NGP : LTT66_23160 LTT66_32895
RFA : A3L23_01571 A3L23_02133 A3L23_04496
RHS : A3Q41_01250 A3Q41_03772
RKO : JWS14_13565 JWS14_16715
RHOP : D8W71_00155 D8W71_15865
TSD : MTP03_03020 MTP03_44390
DLU : A6035_06915 A6035_15815
SGRF : SGFS_011510 SGFS_102070
SCB : SCAB_6891 SCAB_7101(adhC) SCAB_8471
SVL : Strvi_4592 Strvi_5719 Strvi_8775
SHO : SHJGH_2591 SHJGH_7922
SRC : M271_27755 M271_43600
SMAL : SMALA_0688 SMALA_3485
SSOI : I1A49_07035 I1A49_21190
SDV : BN159_0993 BN159_7393
SALS : SLNWT_1486 SLNWT_7273
SVT : SVTN_07845 SVTN_36960
STRE : GZL_05861 GZL_07819
SLC : SL103_06340 SL103_13605 SL103_14820
SCZ : ABE83_03105 ABE83_29655
SCX : AS200_05925 AS200_38670
SRW : TUE45_00395 TUE45_01808
SLE : sle_05100(sle_05100)
SPAV : Spa2297_05210 Spa2297_30005
SGS : AVL59_17795 AVL59_25815
STSI : A4E84_38035 A4E84_39275
SALW : CP975_05105 CP975_32865
SGM : GCM10017557_09080 GCM10017557_69220
SCAD : DN051_05875 DN051_31700 DN051_41600
SPHW : NFX46_14465 NFX46_17425 NFX46_27490
SLS : SLINC_7790 SLINC_8107
SNR : SNOUR_27585 SNOUR_35725
SALU : DC74_1379 DC74_3073
SALL : SAZ_07410 SAZ_16400
SAUO : BV401_07290 BV401_20890
SSIA : A7J05_03330 A7J05_30015
SPUN : BFF78_03530 BFF78_40570
SGV : B1H19_07825 B1H19_14700
SALF : SMD44_00629 SMD44_01423
STRO : STRMOE7_05005 STRMOE7_06405 STRMOE7_13550
SGE : DWG14_00890 DWG14_07312
SLK : SLUN_07875 SLUN_37305
SGD : ELQ87_02700 ELQ87_32785
SCYA : EJ357_02770 EJ357_07160
SKA : CP970_00515 CP970_37120
SGAL : CP966_05370 CP966_32875
SPAD : DVK44_04380 DVK44_29085
SFY : GFH48_05070 GFH48_33560
SAQU : EJC51_07250 EJC51_41805
SRIM : CP984_27370 CP984_35540
SPHV : F9278_43530 F9278_44400
SFUG : CNQ36_02575 CNQ36_33965
SPAC : B1H29_03140 B1H29_30605
SCHA : CP983_02740 CP983_39530
SCOE : CP976_02410 CP976_39400
SSPB : CP982_08290 CP982_39680
SPLA : CP981_03565 CP981_05040 CP981_13080
SBRO : GQF42_39555 GQF42_41100
STUI : GCM10017668_04010 GCM10017668_68650
SCYG : S1361_07755 S1361_35555
SFEU : IM697_16285 IM697_16395 IM697_20905
SDW : K7C20_03435 K7C20_04435 K7C20_12340
SAUH : SU9_002690 SU9_003705 SU9_010605
SPRA : CP972_22255 CP972_32920
SROI : IAG44_37090 IAG44_37840
SXN : IAG42_02105 IAG42_07490
SHK : J2N69_05040 J2N69_34940
SANU : K7396_24265 K7396_31035 K7396_32045
SINE : KI385_05970 KI385_07510 KI385_16060
SLF : JEQ17_07685 JEQ17_38810
SDEC : L3078_41430 L3078_42275 L3078_42370
SAOV : G3H79_31795 G3H79_35630
SDUR : M4V62_35115 M4V62_38445 M4V62_39875
SAKB : K1J60_01465 K1J60_01560 K1J60_02290
SNIG : HEK616_08660 HEK616_25460
SCAE : IHE65_02315 IHE65_02420 IHE65_03280
STUB : MMF93_20830 MMF93_29575
SSPN : LXH13_05295 LXH13_36270
SCIR : STRCI_001443 STRCI_007447
SLON : LGI35_10145 LGI35_38900
STUD : STRTU_004800 STRTU_006285
SANT : QR300_24095 QR300_37175
SYUN : MOV08_27650 MOV08_36305
SJN : RI060_02260 RI060_38965
SCYN : N8I84_06835 N8I84_37495
SHAU : K9S39_29575 K9S39_37540
SKG : KJK29_01550 KJK29_32390
SFP : QUY26_34165 QUY26_37395
SINN : ABB07_02735 ABB07_36320
ARU : ASPU41_06025 ASPU41_17240
PSUL : AU252_12885 AU252_20710
PSEY : GU243_05480 GU243_15460
KFV : AS188_03565 AS188_12585
KRS : EQG70_07285 EQG70_16570
SATK : SA2016_2206 SA2016_3452
PSIM : KR76_01050 KR76_25545
NFS : OIE67_15770 OIE67_40680
MHAI : OHB01_17205 OHB01_19025
FRE : Franean1_2925 Franean1_5066
FRI : FraEuI1c_2779 FraEuI1c_3788
GOB : Gobs_2885 Gobs_2902 Gobs_4761
SEN : SACE_3147 SACE_4443 SACE_4490 SACE_4513
AJA : AJAP_03045 AJAP_16090
AAB : A4R43_09660 A4R43_25480
AMYY : YIM_03985 YIM_25610
ARHD : VSH64_22110 VSH64_32065
PHH : AFB00_07885 AFB00_18080
PAUT : Pdca_07580 Pdca_65350
APRE : CNX65_18865 CNX65_23185
KBU : Q4V64_02990 Q4V64_03980 Q4V64_08685 Q4V64_50690
SACE : GIY23_08460 GIY23_13950
UME : RM788_12885 RM788_31105
AMS : AMIS_51660 AMIS_8200
» show all
Taxonomy
Reference
Authors
Misset-Smits M, van Ophem PW, Sakuda S, Duine JA
Title
Mycothiol, 1-O-(2'-[N-acetyl-L-cysteinyl]amido-2'-deoxy-alpha-D-glucopyranosyl)-D- myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase.
Journal
Reference
Authors
Norin A, Van Ophem PW, Piersma SR, Persson B, Duine JA, Jornvall H
Title
Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaroytic alcohol dehydrogenases--primary structure, conformational modelling and functional correlations.
Journal
Sequence
Reference
Authors
Vogt RN, Steenkamp DJ, Zheng R, Blanchard JS.
Title
The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase.
Journal
Sequence
Reference
Authors
Rawat M, Av-Gay Y
Title
Mycothiol-dependent proteins in actinomycetes.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.306
LinkDB
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