KEGG   ENZYME: 1.1.1.48
Entry
EC 1.1.1.48                 Enzyme                                 
Name
D-galactose 1-dehydrogenase;
D-galactose dehydrogenase;
beta-galactose dehydrogenase (ambiguous);
NAD+-dependent D-galactose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-galactose:NAD+ 1-oxidoreductase
Reaction(IUBMB)
D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+ [RN:R01094]
Reaction(KEGG)
R01094;
(other) R01096 R01097 R08544
Substrate
D-galactose [CPD:C00124];
NAD+ [CPD:C00003]
Product
D-galactono-1,4-lactone [CPD:C03383];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.
History
EC 1.1.1.48 created 1961, modified 2011
Pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
Orthology
K00035  D-galactose 1-dehydrogenase
K22215  galactose dehydrogenase
Genes
XCC: XCC0744(dgd)
XCB: XC_3491
XCA: xcc-b100_3611
XCP: XCR_0916
XCV: XCV0847
XAX: XACM_0792
XAC: XAC0797(dgd)
XCI: XCAW_03785(dgd)
XCT: J151_00922
XCJ: J158_00919
XCU: J159_00919
XCN: J169_00918
XCW: J162_00918
XCR: J163_00918
XCM: J164_00918
XCF: J172_00913
XFU: XFF4834R_chr08000
XAO: XAC29_04060
XOM: XOO3586(XOO3586)
XOO: XOO3804(dgd)
XOP: PXO_04345
XOY: AZ54_04880
XOR: XOC_0862
XOZ: BE73_20070
XFR: BER92_04515
XVE: BJD12_16980
XPE: BJD13_12735
XHR: XJ27_11375
XGA: BI317_04830
XPH: XppCFBP6546_07460(XppCFBP6546P_07460)
XVA: C7V42_04440
XAN: AC801_04115
XAR: XB05_20920
XCZ: EBN15_03050
XEU: XSP_000805
XHD: LMG31886_35330(araA)
XPR: MUG10_06025
XDY: NYR95_04760
PSU: Psesu_0880
PDD: MNQ95_11215
VNI: VIBNI_A1286
POR: APT59_06560
PST: PSPTO_4782(gal)
PSB: Psyr_4331
PSYR: N018_22455
PSP: PSPPH_4371(gal)
PSAV: PSA3335_23655
PAMG: BKM19_025415
PAVL: BKM03_25160
PVD: CFBP1590_0598(gal)
PCAB: JGS08_02840
PCOF: POR16_03360
PTRE: I9H09_20560
PSYI: MME58_22220
PAST: N015_09495
PFE: PSF113_3188
PMAN: OU5_1017(gal)
PCG: AXG94_02455
PMED: E3Z27_13985
PKR: AYO71_13680
PLUL: FOB45_10870
PBA: PSEBR_a2607
PBC: CD58_16835
PRH: LT40_07475
PFK: PFAS1_24545
PPSL: BJP27_21330
PGG: FX982_04466
PVK: EPZ47_16995
PEZ: HWQ56_14755
PBZ: GN234_01850
PATA: JWU58_16555
PZE: HU754_012910
PMOE: HV782_017180
PTZ: HU718_017615
PHV: HU739_006475
PALV: KSS97_16260
PZA: HU749_014375
PIE: HU724_011570
PGF: J0G10_17775
PSII: NF676_11045
PCAS: LOY40_15640
PNB: NK667_15225
PHOM: KJF94_14860
PPAO: K3169_10205
PRHZ: CRX69_05105
PSKU: KUIN1_43280
LAL: AT746_01710
MTHD: A3224_13280
MHYD: GTQ55_15345
MCEL: LPW13_00355
MBRG: PVT68_04425
WMA: WM2015_1134
CSA: Csal_1017
CCAG: SR908_12630
HEL: HELO_2796(araA)
HAK: KO116_00851
HAM: HALO0848
HHU: AR456_09055
HAF: C8233_02095
HMD: CTT34_07260
HSV: HNO53_06465
HPRO: LMS44_19210
HBH: E4T21_11110
HALF: QEN58_16670
HHAO: QWG60_05130
HASH: HXW73_15275
HSR: HSBAA_57040
HNP: SR894_17615
HTT: HZS52_09060
HCAM: I4484_06110
HSX: HNO51_05775
HTX: EKK97_06820
HAA: A5892_01460
CMAI: BFX80_08845
CAMH: LCW13_09160
COBE: CLAM6_17690
COBB: H2O77_09155
KUS: B9G99_10855
KMA: B9H00_03950
KUY: FY550_04035
PAUR: FGL86_17675
SAJS: QO259_04195
MARS: A8C75_00495
MRZ: KDW95_15630
SALN: SALB1_2572
TSN: W908_05220
THIN: CRN91_05305
PLG: NCTC10937_01992(gal)
BGM: CAL15_12825
HSE: Hsero_2708
HSZ: ACP92_13575
HHT: F506_12355
HRB: Hrubri_2793
HHF: E2K99_14415
HFR: G5S34_14390
DUG: HH213_00205 HH213_15800
DZO: SR858_08295
MLO: mll0280 mlr4741
MLN: A9174_03560 A9174_23670
MCI: Mesci_0734 Mesci_3619
MCIC: A4R28_08495 A4R28_24735
MOP: Mesop_0751 Mesop_4628
MAM: Mesau_00714 Mesau_04253
MAMO: A6B35_04175 A6B35_19870
MESW: A9K65_003695 A9K65_019490
MESM: EJ066_07780 EJ066_24325
MESP: C1M53_10555 C1M53_29965
MHUA: MCHK_2076 MCHK_5816
MJR: EB229_03650 EB229_23735
MERD: EB233_03705 EB233_20510
MESR: FGU64_01240 FGU64_16305
MOH: IHQ72_03175 IHQ72_22530
MMEI: LRP31_03220 LRP31_22355
MESO: BSQ44_00970 BSQ44_05225
MES: Meso_0843 Meso_3587
CHEA: PVE73_00525 PVE73_16980
HOE: IMCC20628_02050 IMCC20628_02998
AAK: AA2016_0715
AMIH: CO731_00808(kduD_1)
AMIS: Amn_00840
ANJ: AMD1_0742(galD)
PHT: BLM14_10615 BLM14_29135
PHYL: HB779_23860
RPOD: E0E05_03020
NIY: FQ775_03365 FQ775_08550
ORM: HTY61_08730 HTY61_17220
SME: SMc00588(gal) SMc00880(fabG2)
SMK: Sinme_0533 Sinme_0954
SMQ: SinmeB_0438 SinmeB_0783
SMX: SM11_chr0479(fabG2) SM11_chr2506(gal)
SMI: BN406_00480 BN406_00892(gal)
SMEG: C770_GR4Chr0823 C770_GR4Chr1167
SMEL: SM2011_c00588(gal) SM2011_c00880(fabG2)
SMER: DU99_04260 DU99_06000
SMD: Smed_0438 Smed_0768
RHI: NGR_c04370 NGR_c09060
SFH: SFHH103_00504(fabg1) SFHH103_00835(gal)
SFD: USDA257_c05370(bacC1) USDA257_c08790(gal)
SIX: BSY16_1689 BSY16_2170
SAME: SAMCFNEI73_Ch0860(bacC) SAMCFNEI73_Ch1218(gal)
SINO: SS05631_c05300 SS05631_c08890
ESJ: SJ05684_c04240 SJ05684_c08000
EAK: EKH55_0435 EKH55_0791
EMX: FKV68_04485 FKV68_06230
ENU: PYH37_003034 PYH37_003394
EGI: PZN02_000375 PZN02_003970
SKM: PZL22_004435 PZL22_004775
STEG: QA637_02145 QA637_03915
EAD: OV14_1758 OV14_2179
EAH: FA04_02260 FA04_04405
ECAA: J3R84_02350 J3R84_04350
ENP: JVX98_16185 JVX98_18195
ATU: Atu0705(fabG) Atu1113
ATA: AWN88_23175 AWN88_25140
AGR: AGROH133_04267(fabG) AGROH133_05248(gal)
ATF: Ach5_06290(fabG) Ach5_10290(gal)
AGC: BSY240_2904
AGT: EYD00_01775 EYD00_03870
ALF: CFBP5473_09805 CFBP5473_12260
ARUI: G6M88_10580 G6M88_12895
AVQ: HRR99_02380 HRR99_04990
AVV: RvVAT039_11790
AVF: RvVAR031_31710
ASAL: CFBP5507_01725 CFBP5507_03695
RIR: BN877_I0681 BN877_I1100
RPUS: CFBP5875_02065 CFBP5875_04285
ACUC: KZ699_02035 KZ699_04185
ALEG: CFBP4996_01855 CFBP4996_03955
AVI: Avi_3910
RET: RHE_CH00855(fabG1) RHE_CH01458(gal)
REC: RHECIAT_CH0000944(fabG1) RHECIAT_CH0001526(gal)
REL: REMIM1_CH00868 REMIM1_CH01471
REP: IE4803_CH00866 IE4803_CH01467
REI: IE4771_CH00893 IE4771_CH01517
RLE: RL0917 RL1574
RLT: Rleg2_0503 Rleg2_1072
RLG: Rleg_0546 Rleg_1217
RLB: RLEG3_12890 RLEG3_16465
RLU: RLEG12_13890 RLEG12_16705
RTR: RTCIAT899_CH04105 RTCIAT899_CH06205
RHL: LPU83_0965(fabG1) LPU83_1415(gal)
RGA: RGR602_CH00913 RGR602_CH01354
RHN: AMJ98_CH00874 AMJ98_CH01506
RPHA: AMC79_CH00884 AMC79_CH01485
RHX: AMK02_CH00894 AMK02_CH01514
RHV: BA939_00440 BA939_12475
RHK: Kim5_CH00974 Kim5_CH01592
REZ: AMJ99_CH00874 AMJ99_CH01585
RJG: CCGE525_05060 CCGE525_07415
RHR: CKA34_07215 CKA34_09320
RGR: FZ934_01375 FZ934_03865
RAD: CO657_02605 CO657_05680
ROY: G3A56_05270 G3A56_07555
RII: FFM53_005135 FFM53_008575
RHID: FFM81_013775 FFM81_016715
RBQ: J2J99_04525 J2J99_07530
RLN: J0663_13000 J0663_16230
RBAN: J2J98_04195 J2J98_07295
RRG: J3P73_05235 J3P73_08825
RLS: HB780_29835 HB780_31960
RROS: D4A92_05815
RAW: NE851_14520 NE851_17610
RSUL: N2599_02215 N2599_04580
RLW: RlegWSM1455_02575 RlegWSM1455_06125
RRHO: PR018_01830 PR018_04155
RTU: PR017_01960 PR017_04350
RCT: PYR68_02530 PYR68_05580
ARA: Arad_1105(fabG1) Arad_1691(gal)
ARO: B0909_07805 B0909_09955
RBW: RLCC275e_02645 RLCC275e_06145
RIF: U5G49_000544 U5G49_001253
NGL: RG1141_CH19850 RG1141_CH22060
NGG: RG540_CH20660 RG540_CH22940
NEO: CYG48_08700
NEN: NCHU2750_18160 NCHU2750_35760(gal)
NPM: QEO92_10670 QEO92_11720
RHT: NT26_2220 NT26_3705(fabG)
RFV: RFYW14_02297 RFYW14_03590
SHZ: shn_03770 shn_06395
SZO: K8M09_03380 K8M09_05385
SOJ: K6301_02500 K6301_04790
SSUM: Q9314_04365 Q9314_06780
ABAW: D5400_07040
PDES: FE840_004280
BME: BMEII0355
BMEL: DK63_2884
BMI: BMEA_B0926
BMZ: BM28_B0912
BMG: BM590_B0910
BMW: BMNI_II0882
BMEE: DK62_2513
BMF: BAB2_0293
BMB: BruAb2_0292
BMC: BAbS19_II02780
BAA: BAA13334_II00689
BABO: DK55_2285
BABR: DO74_2705
BABT: DK49_2946
BABB: DK48_2407
BABU: DK53_2296
BABS: DK51_2874
BABC: DO78_2765
BMS: BRA0941
BSI: BS1330_II0933
BSF: BSS2_II0893
BSUI: BSSP1_II0890
BSUP: BSPT1_II0887
BSUV: BSPT2_II0888
BSUC: BSSP2_II0898
BMT: BSUIS_B0934
BSZ: DK67_2894
BSV: BSVBI22_B0932
BSW: IY71_15700
BSG: IY72_15650
BOV: BOV_A0883
BCS: BCAN_B0961(gal)
BSK: BCA52141_II1676
BOL: BCOUA_II0941
BCAR: DK60_2632
BCAS: DA85_14990
BMR: BMI_II935
BVL: BF3285c2_0471
BRU: BFS01_11805
BRJ: BKD03_01850
OIN: IAR37_12310
BIO: BR141012304_20075
OAN: Oant_1420
OAH: DR92_986
OPS: A8A54_07840
BPSN: NIK97_06010
OCH: CES85_1890(gal)
OCR: HGK82_08935
OCL: GTN27_09245
BJA: blr3205(blr3205)
BJU: BJ6T_65470
BJP: RN69_31735
BRA: BRADO1814
BBT: BBta_2134
BRS: S23_47920
AOL: S58_57220
BRC: BCCGELA001_14415
BRAD: BF49_1480
BIC: LMTR13_13405
BRO: BRAD285_5471
BRK: CWS35_13655
BOT: CIT37_37500
BRQ: CIT40_10570
BGQ: X265_25020
BGZ: XH91_23130
BSYM: CIT39_09610
BBET: F8237_04025
BARH: WN72_17540
BVZ: BRAD3257_5483(araA)
BEL: BE61_28990(gal)
BDG: LPJ38_18935
BSEP: HAP48_0007390
BQB: J4P68_0028580
BBAN: J4G43_018540
BCAN: BcanWSM471_15315
BAUT: QA635_09975
BBRA: QA636_09050
BGK: IC762_08100
BCOU: IC761_23485
BPAH: QA639_10735
BXN: I3J27_12435
BROS: QUH67_12900
BRAZ: LRP30_14180
BOP: AXW83_15045
BVV: BHK69_13545
BOF: FQV39_05850 FQV39_07840
STAR: G3545_22985
LNE: FZC33_22290
SNO: Snov_0117
APRA: G3A50_11620
APOL: K9D25_15465
MRD: Mrad2831_1330
MET: M446_4632
MOR: MOC_1687
MPHY: MCBMB27_00985
METX: A3862_24175
MTAD: M6G65_09095
MOC: BB934_26650
MIV: C4E04_11380
MICO: GDR74_10585
MTEZ: HPT29_012300
MLD: U0023_21150
BID: Bind_3077
BBAR: RHAL1_00797(araA)
PHL: KKY_220
PEM: OF122_17165
DEQ: XM25_21300
DEI: C4375_06070
DEA: FPZ08_18255
DSAL: K1X15_00620
DEVO: H4N61_00675
DNP: N8A98_07635
DOY: JI749_01055
DRH: JI748_13590
MMYR: MXMO3_02336 MXMO3_02358
YTI: FNA67_02615
MHAR: L1P08_09440
MAAD: AZF01_16590
MLUT: JET14_18795
AUA: M673_09265
AALA: IGS74_17540
AALM: LUX29_19605
AUZ: Sa4125_16520(gal)
AUB: LXB15_00445
JIE: OH818_09150
JAV: OXU80_22835
PSF: PSE_2806
PPHR: APZ00_12525 APZ00_20900
LAP: ACP90_05475 ACP90_20260
LABR: CHH27_15175
LABP: FJ695_08295
LABT: FIU93_11110(kduD1) FIU93_26815(araA2)
LAGG: B0E33_03985 B0E33_17030
LIZ: LGH83_12380
ACUT: MRB58_08545
CCR: CC_0967
CCS: CCNA_01018
CAK: Caul_3616 Caul_3971
CSE: Cseg_1896 Cseg_3324
CHQ: AQ619_05210
CFH: C1707_10930
CAUF: CSW63_18295
CAUL: KCG34_15460
BRL: BZG35_12360
AEX: Astex_1898
SIT: TM1040_3488
RUA: D1823_19580
RUT: FIU92_19050(kduD3)
RCON: K3740_22355
JAN: Jann_3834
RDE: RD1_2866
RLI: RLO149_c015750 RLO149_c021980(gal)
RPON: G3256_11280
DSH: Dshi_1243
PGA: PGA1_c07370
PGL: PGA2_c06870
PGD: Gal_02755
PHP: PhaeoP97_02455
PPIC: PhaeoP14_00657
PHQ: D1820_16715
OAT: OAN307_c48590(gal)
OAR: OA238_c48520(gal)
OTM: OSB_32620(araA)
OCT: FTO60_16290
CMAR: IMCC12053_1223
MALG: MALG_02110 MALG_04458
YPAC: CEW88_14240
YAN: AYJ57_16180
SULZ: C1J03_00790 C1J03_06065
SULD: B5M07_18740
SPOT: G6548_05985
SMED: JNX03_01685 JNX03_16730
SUAL: KDD17_17035
SPSE: SULPSESMR1_02141(xylB)
TOM: BWR18_10350
RMM: ROSMUCSMR3_00498(xylB)
ROK: RAK1035_3332
AHT: ANTHELSMS3_00004 ANTHELSMS3_03457(araA)
SAGU: CDO87_14400 CDO87_19375
THAA: CFI11_06380
OCD: FHY55_19130
MALU: KU6B_19300 KU6B_40840
TGL: HFZ77_19080
HAT: RC74_03105
PALX: GQA70_14555
LSAL: KBK07_02125 KBK07_02860
TRY: QF118_16765
PLCG: RVY76_09240
MARU: FIU81_05390(araA1) FIU81_07550(kduD1) FIU81_10735(araA2)
RMAI: MACH21_31490
RSP: RSP_1369
RSH: Rsph17029_0037
RSQ: Rsph17025_0027
RSK: RSKD131_2769
CAZT: LV780_00130
RBL: B6K69_04595 B6K69_06870
PDE: Pden_4245
PAMI: JCM7686_3307
PYE: A6J80_10165
PCON: B0A89_06250
PZH: CX676_01055
PAMN: pAMV1p0045(araA)
PARR: EOJ32_16375 EOJ32_18520
PAAK: FIU66_12035
PKD: F8A10_05995
PPAN: ESD82_02805
PLIA: E4191_18495
PSAN: HGN31_05895
PMAU: CP157_03312(araA_1) CP157_03401(araA_2)
PMEH: JWJ88_16275
PSEW: JHW44_18235
PSAP: JHX88_03670
PFIS: JHX87_07160
PAEX: JHW48_00910 JHW48_17205
PALP: JHW40_20105
PVER: E3U25_07925
PDIM: PAF18_07055
PFEO: E3U26_22730
PTP: RCA23_c01430
RMB: K529_016095
DON: BSK21_10855
RBZ: B9057_15765
THW: BMG03_12815
TEC: AKL02_014740
LVS: LOKVESSMR4R_02335(xylB) LOKVESSMR4R_03347(araA)
GEH: HYN69_13900
GFU: KM031_14700
TAW: EI545_06570 EI545_13710
SALO: EF888_19160
SEDI: EBB79_05250
PPSO: QPJ95_01510
BOO: E2K80_13290
LIT: FPZ52_03870
MON: G8E03_05240
POZ: I0K15_05845
PALW: PSAL_020900(araA)
PSHQ: F3W81_19110
PPAF: I8N54_02190 I8N54_16550
CACT: HZ995_05760
FAP: GR316_12410
GCE: KYE46_03945
NSM: JO391_08220 JO391_15130
AALK: LGT41_0011055
AMYL: QBD29_04975
AMAQ: GO499_03060 GO499_18995
RHOC: QTA57_03070
PBAE: P8S53_04310 P8S53_17455
LVR: T8T21_14220 T8T21_19185
FAQ: G5B39_00745
NPP: PP1Y_Mpl1273
NRE: BES08_06875 BES08_21445
NOV: TQ38_022505 TQ38_022665
NOT: C7W88_19915
NOR: FA702_20185
NDR: HT578_07030
NHUM: PQ457_02040 PQ457_20245
SAL: Sala_0745
SPHK: SKP52_01885(araA)
SPHX: E5675_04610
SINA: KNJ79_17385
SPHU: SPPYR_0433(araA)
SPHM: G432_06460
STAX: MC45_07850
SPHI: TS85_21120
SSAN: NX02_07110 NX02_12675
SNJ: A7E77_05030
SMY: BJP26_00310
SPAN: AWL63_01185 AWL63_05170
SKR: BRX40_07015
SPLK: AV944_13915
SPHF: DM480_08630
SPAU: DRN02_007175
SPAP: H3Z74_00310
SPII: G7077_07600
SSIN: G7078_02965
SARI: H5J25_14685
SSUA: FPZ54_00175 FPZ54_02615 FPZ54_13705
SBIN: SBA_ch1_01370(gal_1) SBA_ch1_35830(gal_2)
SAER: NEF64_12275
SMOR: LHA26_06155 LHA26_11340
SGLC: M1K48_06650
SQO: NMP03_05940
SCAB: LZK98_03560
SRAD: LLW23_11805
SHAN: PPZ50_15320
SNOS: K8P63_08530
SSAG: KV697_05150
SABI: PBT88_03585
SJP: SJA_C1-05950
SINB: SIDU_10715
SYB: TZ53_11220 TZ53_22195
SPHB: EP837_03127
SPHR: BSY17_1053 BSY17_2379
SPHT: K426_04590 K426_16895
SHYD: CJD35_07410
SYA: A6768_01760 A6768_17815
SPYG: YGS_C1P1796 YGS_C1P2079
SUFL: FIL70_11350 FIL70_17145
SBAR: H5V43_09110 H5V43_12365
SAMI: SAMIE_1002330
SPZR: G5C33_10840
SPHS: ETR14_02030 ETR14_18295
SFLV: IC614_08275
POQ: KZX46_02320 KZX46_06430 KZX46_07780 KZX46_12520
PMEA: KTC28_03380 KTC28_04750 KTC28_10375
AAY: WYH_02192(araA)
ADO: A6F68_00759(araA)
CMAN: A9D14_05810
QCI: NCF85_08000
POT: E2E27_08030
KBA: A0U89_02165
RGI: RGI145_17595
ROS: CTJ15_16445
RMUC: FOB66_22030
AZL: AZL_e03690(gal)
ALI: AZOLI_p50383
ABS: AZOBR_p440166
ABQ: ABAZ39_31625
ABF: AMK58_27415
ATI: AL072_30970
AHU: A6A40_14260
AZT: TSH58p_21390
AZM: DM194_26405
AZZ: DEW08_21985
AOZ: HUE56_23235
AARE: D3093_27795
AZS: E6C72_28420
NAO: Y958_16055 Y958_28205
NCB: C0V82_22765
THAR: T8K17_03170
TMO: TMO_a0253
PRZ: GZH47_16905
NANO: G5V58_18475
MFF: MFFC18_12940(ped)
 » show all
Reference
1  [PMID:13462997]
  Authors
DE LEY J, DOUDOROFF M.
  Title
The metabolism of D-galactose in Pseudomonas saccharophila.
  Journal
J Biol Chem 227:745-57 (1957)
Reference
2  [PMID:14251301]
  Authors
HU AS, CLINE AL.
  Title
THE REGULATION OF SOME SUGAR DEHYDROGENASES IN A PSEUDOMONAD.
  Journal
Biochim Biophys Acta 93:237-45 (1964)
DOI:10.1016/0304-4165(64)90371-X
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.48
IUBMB Enzyme Nomenclature: 1.1.1.48
ExPASy - ENZYME nomenclature database: 1.1.1.48
BRENDA, the Enzyme Database: 1.1.1.48
CAS: 9028-54-0
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