KEGG   ENZYME: 1.1.1.50
Entry
EC 1.1.1.50                 Enzyme                                 
Name
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific);
hydroxyprostaglandin dehydrogenase;
3alpha-hydroxysteroid oxidoreductase;
sterognost 3alpha;
3alpha-hydroxysteroid dehydrogenase (B-specific);
3alpha-hydroxysteroid 3-dehydrogenase (B-specific);
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (B-specific)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Si-specific)
Reaction(IUBMB)
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ [RN:R10422 R10423]
Reaction(KEGG)
R10422 > R02476 R04309 R04818 R04824 R04829 R04832 R04835 R04837 R04842 R04845;
R10423 > R02477 R04310 R04819 R04825 R04830 R04833 R04836 R04838 R04843 R04846 R08963
Substrate
3alpha-hydroxysteroid [CPD:C03072];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on androsterone and other 3alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. Si-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.213, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific).
History
EC 1.1.1.50 created 1961, modified 1986, modified 1990, modified 2012, modified 2013
Pathway
ec00120  Primary bile acid biosynthesis
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
Genes
HSA: 1109(AKR1C4)
PTR: 450274(AKR1C4)
PPS: 100987989(AKR1C4)
GGO: 101148343
PON: 100434557(AKR1C4)
NLE: 100605385
HMH: 116461800(AKR1C4)
MCC: 722483 722490(AKR1C4)
MCF: 102116844 102117205(AKR1C4)
MTHB: 126963007
MNI: 105490779
CSAB: 103237814
CATY: 105597444 105597447
PANU: 101022938
TGE: 112631314
MLEU: 105535763
RRO: 104674748
RBB: 108521035
TFN: 117082119 117082359
CANG: 105521699 105521705
CJC: 100405255 100405615(AKR1C4)
SBQ: 101041915
CIMI: 108292324(AKR1C4) 108292325
OGA: 100940488
MMMA: 107150202
GVR: 103581518
ECB: 100057251
EPZ: 103540777
EAI: 106827243
LAV: 100660861
DNM: 101426998
XLA: 108712557(akr1c4.S)
XTR: 496490(akr1c4)
NPR: 108799292
RTEM: 120932842
BBUF: 121003666
BGAR: 122926607
 » show all
Reference
1  [PMID:14406805]
  Authors
JARABAK J, TALALAY P.
  Title
Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 235:2147-51 (1960)
Reference
2  [PMID:13405910]
  Authors
KOCHAKIAN CD, CARROLL BR, UHRI B.
  Title
Comparisons of the oxidation of C19-hydroxysteroids by guinea pig liver homogenates.
  Journal
J Biol Chem 224:811-8 (1957)
Reference
3  [PMID:13295221]
  Authors
MARCUS PI, TALALAY P.
  Title
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 218:661-74 (1956)
Reference
4  [PMID:3479982]
  Authors
Penning TM, Sharp RB
  Title
Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.
  Journal
Biochem Biophys Res Commun 148:646-52 (1987)
DOI:10.1016/0006-291X(87)90925-9
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.50
IUBMB Enzyme Nomenclature: 1.1.1.50
ExPASy - ENZYME nomenclature database: 1.1.1.50
BRENDA, the Enzyme Database: 1.1.1.50
CAS: 9028-56-2
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