KEGG   ENZYME: 1.1.1.9
Entry
EC 1.1.1.9                  Enzyme                                 
Name
D-xylulose reductase;
NAD+-dependent xylitol dehydrogenase;
xylitol dehydrogenase (ambiguous);
erythritol dehydrogenase;
2,3-cis-polyol(DPN) dehydrogenase (C3-5);
pentitol-DPN dehydrogenase (ambiguous);
xylitol-2-dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
xylitol:NAD+ 2-oxidoreductase (D-xylulose-forming)
Reaction(IUBMB)
xylitol + NAD+ = D-xylulose + NADH + H+ [RN:R01896]
Reaction(KEGG)
R01896
Substrate
xylitol [CPD:C00379];
NAD+ [CPD:C00003]
Product
D-xylulose [CPD:C00310];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts as an L-erythrulose reductase.
History
EC 1.1.1.9 created 1961
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K05351  D-xylulose reductase
Genes
PPOI: 119101951
AHF: 112804057
SCE: YLR070C(XYL2)
SEUB: DI49_3597
SPAO: SPAR_L01250
KLA: KLLA0_D05511g
KMX: KLMA_70044(SOR1)
LTH: KLTH0G18986g
ZRO: ZYRO0F02552g
NCS: NCAS_0J00300(NCAS0J00300)
TDL: TDEL_0C00390(TDEL0C00390)
ZMK: HG535_0D06020
PPA: PAS_chr1-1_0490
DHA: DEHA2A13992g
PIC: PICST_86924(XYL2)
PGU: PGUG_05726
SPAA: SPAPADRAFT_59053(XYL2.1) SPAPADRAFT_59888(XYL2.2)
LEL: PVL30_002352(XYL2)
CAL: CAALFM_CR10840CA(XYL2)
CTP: CTRG_05796
COT: CORT_0D00360
CDU: CD36_35570(XYL2)
CTEN: CANTEDRAFT_103058 CANTEDRAFT_115939
YLI: YALI0E12463g
CLU: CLUG_02658
CLUS: A9F13_07g02013
CAUR: CJI96_0000472 CJI96_0001804
SLB: AWJ20_4946(SOR1)
PKZ: C5L36_0C05200
BNN: FOA43_001579
BBRX: BRETT_002160
OPA: HPODL_00131
NCR: NCU00891
NTE: NEUTE1DRAFT71383(NEUTE1DRAFT_71383)
SMP: SMAC_01577
PAN: PODANSg09388
PBEL: QC761_101490(XYL2_2)
PPSD: QC762_101490(XYL2_2)
PPSP: QC763_101490(XYL2_2)
PPSA: QC764_101490(XYL2_2)
TTT: THITE_2120696
MTM: MYCTH_2293953
CTHR: CTHT_0073860
MGR: MGG_01176
PPEI: PpBr36_00672
PGRI: PgNI_04388
TMN: UCRPA7_5640 UCRPA7_6056 UCRPA7_7026 UCRPA7_8483
SSCK: SPSK_01724 SPSK_01795
FGR: FGSG_04247 FGSG_04922
FPU: FPSE_03960 FPSE_08741
FPOA: FPOAC1_006704 FPOAC1_007793
FVN: FVRRES_07325 FVRRES_08328
FVR: FVEG_03564 FVEG_10437
FOX: FOXG_05699 FOXG_11380
NHE: NECHADRAFT_81006 NECHADRAFT_96600 NECHADRAFT_99030
FFC: NCS54_00180200 NCS54_00868700 NCS54_01222100
FKR: NCS57_00177700 NCS57_01209600
FMU: J7337_003582 J7337_011713
TRE: TRIREDRAFT_81271(xdh1)
TRR: M419DRAFT_26280
MAW: MAC_04004 MAC_04777
MAJ: MAA_01247 MAA_08094 MAA_08438 MAA_10698
PCHM: VFPPC_01326 VFPPC_08769 VFPPC_11095 VFPPC_15454
CMT: CCM_03621 CCM_06993
AMUS: LMH87_011856
PLJ: VFPFJ_02524 VFPFJ_06453 VFPFJ_06519 VFPFJ_10159
PTKZ: JDV02_004041 JDV02_008894(XYL2) JDV02_009623 JDV02_010303
VAL: VDBG_09895
VDA: VDAG_06181
CFJ: CFIO01_01721 CFIO01_10019 CFIO01_10801
CLUP: CLUP02_07016
CHIG: CH63R_05393 CH63R_10797
SAPO: SAPIO_CDS1318
ELA: UCREL1_11318 UCREL1_6767 UCREL1_7418 UCREL1_7517
PFY: PFICI_04520 PFICI_05411 PFICI_05847 PFICI_10488 PFICI_10680 PFICI_11930 PFICI_12195 PFICI_13596
SSL: SS1G_05978
BFU: BCIN_05g01030
MBE: MBM_06974
PSCO: LY89DRAFT_627171 LY89DRAFT_669699 LY89DRAFT_692458
GLZ: GLAREA_04650 GLAREA_10937
ANI: ANIA_08109 ANIA_09064
AFM: AFUA_7G02550
ACT: ACLA_065000
NFI: NFIA_098450 NFIA_115270
AOR: AO090020000647 AO090020000676 AO090038000631 AO090103000393 AO090701000411
ANG: An05g02260 An08g09380 An12g00030 An15g04610
AFV: AFLA_004927 AFLA_009114 AFLA_009974 AFLA_009999
ALUC: AKAW2_60288A AKAW2_80295A AKAW2_80979S AKAW2_81370A
ACHE: ACHE_10088S ACHE_50430S ACHE_60231S ACHE_70571S ACHE_80524A
APUU: APUU_31523S APUU_40899A APUU_50400S APUU_60918S
PCS: N7525_002218 N7525_007734 N7525_010653 N7525_010728
PDP: PDIP_56650
POU: POX_b02131
TMF: EYB26_009603
TRG: TRUGW13939_02074 TRUGW13939_09269
CIM: CIMG_07715
CPW: CPC735_042480
URE: UREG_07581
PBL: PAAG_08336
PBN: PADG_04265
ABE: ARB_04704
TVE: TRV_03145
AJE: HCAG_04376
BGH: BDBG_02009
PNO: SNOG_11390 SNOG_14172
PTE: PTT_13959 PTT_17847
BZE: COCCADRAFT_104857 COCCADRAFT_38991
BSC: COCSADRAFT_250797 COCSADRAFT_40924
BOR: COCMIDRAFT_34708 COCMIDRAFT_36528
AALT: CC77DRAFT_1054477 CC77DRAFT_1099313
ARAB: EKO05_0003626 EKO05_0003745
ZTR: MYCGRDRAFT_31918 MYCGRDRAFT_70997(MgXDH1)
PFJ: MYCFIDRAFT_85679 MYCFIDRAFT_89205
FFU: CLAFUR5_11880
CBET: CB0940_00152 CB0940_11633
BCOM: BAUCODRAFT_145706
NPA: UCRNP2_1001 UCRNP2_5372 UCRNP2_9631
TML: GSTUM_00005037001
SPO: SPBC1773.05c(tms1)
SOM: SOMG_02449(tms1)
CNE: CNA01050 CNA02580 CNC06670
CNB: CNBA1020 CNBA2420 CNBC0530
CNG: CNAG_00115 CNAG_00269 CNAG_07589
CGI: CGB_B1280C CGB_B2810C CGB_C0560C
CDEU: CNBG_0301 CNBG_0440 CNBG_3919
TMS: TREMEDRAFT_43291 TREMEDRAFT_69576 TREMEDRAFT_71743 TREMEDRAFT_73604
TASA: A1Q1_00129 A1Q1_03829 A1Q1_03910 A1Q1_06087
CCAC: CcaHIS019_0105810(CcaverHIS019_0105810) CcaHIS019_0203390(CcaverHIS019_0203390) CcaHIS019_0204830(CcaverHIS019_0204830) CcaHIS019_0504670(CcaverHIS019_0504670) CcaHIS019_0601150(CcaverHIS019_0601150)
TVS: TRAVEDRAFT_144293
DSQ: DICSQDRAFT_136749 DICSQDRAFT_86636
PCO: PHACADRAFT_249477
SHS: STEHIDRAFT_127586 STEHIDRAFT_77236
HIR: HETIRDRAFT_408174
PSQ: PUNSTDRAFT_99938
ADL: AURDEDRAFT_110512 AURDEDRAFT_188788
FME: FOMMEDRAFT_109815 FOMMEDRAFT_109904 FOMMEDRAFT_135448 FOMMEDRAFT_157646
GTR: GLOTRDRAFT_55488
LBC: LACBIDRAFT_188827
CCI: CC1G_00399
ABP: AGABI1DRAFT113352(AGABI1DRAFT_113352)
ABV: AGABI2DRAFT192003(AGABI2DRAFT_192003)
PCUB: JR316_0004665
MPR: MPER_03874
MRR: Moror_7449
MORE: E1B28_007666
SCM: SCHCO_02612591(SCHCODRAFT_02612591) SCHCO_02621873(SCHCODRAFT_02621873)
CPUT: CONPUDRAFT_137211 CONPUDRAFT_81649
SLA: SERLADRAFT_461886
WSE: WALSEDRAFT_16425
WIC: J056_004738
UMA: UMAG_02150
PFP: PFL1_00406
SGRA: EX895_005002
MGL: MGL_4135
MRT: MRET_3689
MSYM: MSY001_1216
PIF: PITG_04121 PITG_04983 PITG_04985 PITG_04989
PSOJ: PHYSODRAFT_310790
KLL: BJF97_02915
KLW: DA718_25210
SMAR: SM39_2158
SMAC: SMDB11_1955
SMW: SMWW4_v1c27000(ydjJ)
SERF: L085_15315
SERS: SERRSCBI_12665
SFG: AV650_13745
SSUR: ATE40_010105
SURI: J0X03_10470
SNEM: NLX84_13585
SFO: Z042_20975
SGL: SG0610
SOD: Sant_3108
SLIG: GTU79_26695
ETA: ETA_16670
ERP: LJN55_05905
PANT: PSNIH1_00765
PER: LAC65_11285
KPIE: N5580_18905
PLU: plu1960
PLUM: A4R40_09815
PAY: PAU_02204(ydjJ)
PAKH: B0X70_10095
PLUI: CE143_10005
PSI: S70_17590
PSX: DR96_2471(xyl2)
PSTA: BGK56_19825
PTHA: OI982_05760
PVC: G3341_13485
PMAG: JI723_13385
MMK: MU9_3130
PFQ: QQ39_16335
AVN: Avin_16590 Avin_20290
AVL: AvCA_16590 AvCA_20290
AVD: AvCA6_16590 AvCA6_20290
ACX: Achr_19720
ABER: BSR55_14545
SPL: Spea_2286
SHL: Shal_2008
CSA: Csal_2609
HALF: QEN58_01205
HOL: HORIV_03610
HAA: A5892_17465
KUS: B9G99_10290
KMA: B9H00_04540
KUY: FY550_02190
MARS: A8C75_01555
MRZ: KDW95_14690
SALN: SALB1_1584
BMA: BMAA1076
BMV: BMASAVP1_0068
BML: BMA10229_0351
BMN: BMA10247_A1235
BMAL: DM55_4585
BMAE: DM78_3785
BMAQ: DM76_3537
BMAI: DM57_11320
BMAF: DM51_4751
BMAZ: BM44_4352
BMAB: BM45_3476
BPS: BPSS1235
BPM: BURPS1710b_A0234
BPL: BURPS1106A_A1653
BPD: BURPS668_A1742
BPSE: BDL_4525
BPSM: BBQ_4932
BPSU: BBN_4664
BPSD: BBX_3688
BPZ: BP1026B_II1310
BPQ: BPC006_II1646
BPK: BBK_5875
BPSH: DR55_4057
BPSA: BBU_4822
BPSO: X996_4436
BUT: X994_5901
BTE: BTH_II1176
BTQ: BTQ_4460(sorD)
BTJ: BTJ_5441(sorD)
BTZ: BTL_3904
BTD: BTI_3735
BTV: BTHA_3976
BTHE: BTN_3757
BTHM: BTRA_4457(sord)
BTHA: DR62_3793
BTHL: BG87_3916
BOK: DM82_5405
BOC: BG90_5203
BUU: WS70_23815
BHG: I6G56_21825
BUD: AQ610_24555
BUR: Bcep18194_B3068
BCM: Bcenmc03_4382
BCH: Bcen2424_5797
BCJ: BCAM0097
BCEO: I35_4106
BMUL: NP80_3465
BCED: DM42_5056
BCON: NL30_25000
BSEM: WJ12_21085
BMEC: WJ16_20345
BSTL: BBJ41_28420
BARI: NLX30_22255
BGF: BC1003_3828
BYI: BYI23_D008410
BUE: BRPE67_DCDS10340
BUL: BW21_5730
BUQ: AC233_27380
BUM: AXG89_35410
BUI: AX768_17080
BURK: DM992_26890
BPH: Bphy_6662
BGE: BC1002_5589
BFN: OI25_5778
BCAI: K788_0000121
PARA: BTO02_06610
PHS: C2L64_30455
PTER: C2L65_27170
PGP: CUJ91_28825 CUJ91_31810
PTS: CUJ90_21540
PMEG: FNZ07_30215
PEW: KZJ38_17355
PBRY: NDK50_09780
PSAA: QEN71_33850
BUO: BRPE64_DCDS03300
CABK: NK8_60990
VPE: Varpa_4066
VBO: CKY39_23015
JAZ: YQ44_03770
JAL: BZG29_23780
JSV: CNX70_24210
JAS: FJQ89_13445
JLV: G3257_24455
JAH: JAB4_048420
JRI: P9875_24765
HSE: Hsero_3396
HHT: F506_15925
HRB: Hrubri_3413
HHF: E2K99_17675
HFR: G5S34_18730
CARE: LT85_3029
CPRA: CPter91_2190
MLO: mlr4915
MLN: A9174_02810
MOP: Mesop_0570
MAM: Mesau_00518
MAMO: A6B35_10320
MESP: C1M53_23435
MHUA: MCHK_5976
MJR: EB229_02855
MERD: EB233_02965
CHEA: PVE73_08575
PHYL: HB779_25075
SME: SMc01992
SMK: Sinme_2575
SMQ: SinmeB_2355
SMX: SM11_chr2680
SMI: BN406_02374
SMEG: C770_GR4Chr2627
SMEL: SM2011_c01992
SMER: DU99_14035
SMD: Smed_0849
SIX: BSY16_3535
SKM: PZL22_002861
STEG: QA637_21165
EAH: FA04_27450
ENP: JVX98_04820
ATU: Atu4318
ATA: AWN88_04145 AWN88_04450
AGR: AGROH133_13378 AGROH133_15260
ATF: Ach5_40550
AGT: EYD00_20235 EYD00_20545
ALF: CFBP5473_20840
ARUI: G6M88_21470
AVQ: HRR99_20775
ASAL: CFBP5507_17620
RIR: BN877_II1327 BN877_II1387
RPUS: CFBP5875_20460 CFBP5875_20770
ACUC: KZ699_21545
ALEG: CFBP4996_22825
RET: RHE_PE00181 RHE_PE00268
REC: RHECIAT_PA0000139 RHECIAT_PA0000213
REL: REMIM1_PD00184 REMIM1_PD00283
REP: IE4803_PA00213
REI: IE4771_PC00128 IE4771_PC00215
RLE: pRL110382(sorD)
RLT: Rleg2_5833
RLG: Rleg_6746
RLB: RLEG3_04550
RLU: RLEG12_00990 RLEG12_02890
RTR: RTCIAT899_PC03125
RHL: LPU83_pLPU83d0057
RGA: RGR602_PC01011 RGR602_PC01881
RHN: AMJ98_PD00279
RPHA: AMC79_PB00218
RHX: AMK02_PE00279
RHV: BA939_19180
RHK: Kim5_PB00159 Kim5_PB00249
REZ: AMJ99_PC00280
RHR: CKA34_22740
RGR: FZ934_25405
RAD: CO657_29810
ROY: G3A56_13120 G3A56_23585
RII: FFM53_029830
RHID: FFM81_029045
RBQ: J2J99_27925
RLN: J0663_14755 J0663_27655
RBAN: J2J98_05945 J2J98_25090
RRG: J3P73_30055
RLS: HB780_08640
RROS: D4A92_22545
RAW: NE851_03625
RSUL: N2599_24275 N2599_27695
RLW: RlegWSM1455_30475
RRHO: PR018_12775
RTU: PR017_12805
ARA: Arad_12135 Arad_7087 Arad_8677
ARO: B0909_16470
RBW: RLCC275e_29340
NGL: RG1141_CH41290
NGG: RG540_CH41810
NEO: CYG48_01485
NEN: NCHU2750_38160
NPM: QEO92_25110
RHT: NT26_3942
RFV: RFYW14_03974
SHZ: shn_17180
SOJ: K6301_21615
SSUM: Q9314_26580
KAI: K32_04730
BPSN: NIK97_18840
STAR: G3545_21515
LNE: FZC33_30715
SNO: Snov_0847
APRA: G3A50_17140
APOL: K9D25_19780
MOC: BB934_16540
MTEZ: HPT29_004235
MLD: U0023_23310
BID: Bind_2341 Bind_3810
DEQ: XM25_12530
DEA: FPZ08_10345
DNP: N8A98_14300
DOY: JI749_03685 JI749_07430
YTI: FNA67_16250
MHAR: L1P08_01940
PLEO: OHA_1_04233
HDI: HDIA_0690 HDIA_P0059
MMED: Mame_01904
AUA: M673_09200
AALA: IGS74_12860
AALM: LUX29_14740
AUZ: Sa4125_08210 Sa4125_19590
JIE: OH818_14440
LIZ: LGH83_06805 LGH83_08900
RUT: FIU92_21990
RDE: RD1_3623(xdh)
RLI: RLO149_c008420
DSH: Dshi_0551(xylD)
CMAR: IMCC12053_2454
TPRO: Ga0080559_TMP340
PABY: Ga0080574_TMP197 Ga0080574_TMP496
OCD: FHY55_12550
PALX: GQA70_21540
TRY: QF118_16000
RSQ: Rsph17025_3580
CAZT: LV780_17855
PDE: Pden_2163
PYE: A6J80_09200 A6J80_22280
PAMN: JCM7685_0945
PARR: EOJ32_15835
PKD: F8A10_02985
PPAN: ESD82_13270
PLIA: E4191_06355
PMAU: CP157_00436
PMEH: JWJ88_08030
PSEW: JHW44_14965
PSAP: JHX88_15880
PAEX: JHW48_12565
PALP: JHW40_20790
PVER: E3U25_23245
PFEO: E3U26_11385
RMB: K529_018670
DAA: AKL17_2146
GFU: KM031_17430
SALO: EF888_13930
BOO: E2K80_03620
LIT: FPZ52_15435
PPAF: I8N54_14075
CMAG: CBW24_07745
AMAQ: GO499_07855
PBAE: P8S53_05460 P8S53_16905
GOH: B932_3019
GTI: FXF46_12505
GFA: MKW11_06565
GDI: GDI3142
GDJ: Gdia_3230
GXL: H845_1385
KEU: S101446_00518
ABG: Asbog_02193
KBA: A0U89_01600
RGI: RGI145_12850
ROS: CTJ15_23505
RMUC: FOB66_14520
COQ: D9V35_00250
COMM: GN303_00435
LCK: HN018_18475
RAP: RHOA_4598
NGU: QN315_12675
RRU: Rru_A0252
RRF: F11_01275
TII: DY252_05845
BHAI: KJK41_19780
PPOL: X809_28040
PMS: KNP414_01889
PMQ: PM3016_2175
PMW: B2K_11180
KRS: EQG70_00825
RKR: I6G21_05420
BFA: Bfae_15800
BRX: BH708_03340
BRV: CFK39_00415
BGG: CFK41_08865
BRZ: CFK38_03210 CFK38_11065
BSAU: DWV08_05395
BKI: M4486_05630
BHH: Bra3105_02415
PBO: PACID_04280
AACI: ASQ49_02920
ACIJ: JS278_02913
ACQ: AM609_07020
ACTZ: CWT12_05870
AVC: NCTC10951_00727
ALIL: D5R93_01605
WIK: H8R18_05925
BLJ: BLD_1700(tdh3)
BLK: BLNIAS_00276(tdh3)
BLZ: BLGT_09010
BAD: BAD_0317
BADL: BADO_0324
BADO: BBMN23_0346
BBV: HMPREF9228_1701
BBRE: B12L_1575
BBRV: B689b_1676
BBRJ: B7017_1843
BBRC: B7019_1816
BBRS: BS27_1628
BBRD: BBBR_1646
BKS: BBKW_0346
BCAT: BBCT_0305
BPSC: BBPC_0333
BSUE: BS3272_08260
BNK: KIM372_04980
NAB: B1sIIB91_01955
CAP: CLDAP_13590
KBB: ccbrp13_11680
SLOM: PXH66_01865
BMEI: Spa11_20300
HBS: IPV69_13400
TPI: TREPR_0134
SFC: Spiaf_0415
OCK: EXM22_09350
SGP: SpiGrapes_2365
 » show all
Reference
1  [PMID:13692998]
  Authors
CHIANG C, KNIGHT SG.
  Title
A new pathway of pentose metabolism.
  Journal
Biochem Biophys Res Commun 3:554-9 (1960)
DOI:10.1016/0006-291x(60)90174-1
Reference
2  [PMID:13654257]
  Authors
HICKMAN J, ASHWELL G.
  Title
A sensitive and stereospecific enzymatic assay for xylulose.
  Journal
J Biol Chem 234:758-61 (1959)
Reference
3  [PMID:13789254]
  Authors
JAKOBY WB, FREDERICKS J.
  Title
Erythritol dehydrogenase from Aerobacter aerogenes.
  Journal
Biochim Biophys Acta 48:26-32 (1961)
DOI:10.1016/0006-3002(61)90511-X
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.9
IUBMB Enzyme Nomenclature: 1.1.1.9
ExPASy - ENZYME nomenclature database: 1.1.1.9
BRENDA, the Enzyme Database: 1.1.1.9
CAS: 9028-16-4
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