KEGG ENZYME: 1.12.98.2

ENZYME: 1.12.98.2

Entry

EC 1.12.98.2                Enzyme

Name

5,10-methenyltetrahydromethanopterin hydrogenase;
H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase;
nonmetal hydrogenase;
N5,N10-methenyltetrahydromethanopterin hydrogenase;
hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase

Class

Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors

Sysname

hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase

Reaction(IUBMB)

H2 + 5,10-methenyltetrahydromethanopterin = H+ + 5,10-methylenetetrahydromethanopterin [RN:R04455]

Reaction(KEGG)

R04455

Substrate

H2 [CPD:C00282];
5,10-methenyltetrahydromethanopterin [CPD:C04330]

Product

H+ [CPD:C00080];
5,10-methylenetetrahydromethanopterin [CPD:C04377]

Comment

Does not catalyse the reduction of artificial dyes. Does not by itself catalyse a H2/H+ exchange reaction. Does not contain nickel or iron-sulfur clusters.

History

EC 1.12.98.2 created 1999 as EC 1.12.99.4, transferred 2002 to EC 1.12.98.2, modified 2004

Pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K13942

5,10-methenyltetrahydromethanopterin hydrogenase

Genes

MJA:

MJ_0784

MFE:	Mefer_0990

MVU:	Metvu_0027

MFS:	MFS40622_1391

MIF:	Metin_0843

MJH:	JH146_1110

MESG:

MLAUSG7_0273(hmd)

MESA:

MLASG1_1401(hmd)

MIG:	Metig_1130

MMP:	MMP0127(hmd)

MMQ:	MmarC5_1551

MMX:	MmarC6_0825

MMZ:	MmarC7_1126

MMD:

GYY_00645

MMAK:

MMKA1_01320(hmd)

MMAO:

MMOS7_01580(hmd)

MMAD:

MMJJ_09590

MAE:

Maeo_1025

MVN:	Mevan_1132

MVO:

Mvol_1349

MOK:	Metok_0558

METF:

CFE53_06010

MTH:

MTH_1142

MMG:	MTBMA_c15260(hmd)

MWO:	MWSIV6_1534(hmd)

MTEE:

MTTB_02800

METC:

MTCT_1035

METE:

tca_01099

METZ:

METMT2_1150

METK:

FVF72_05875(hmd)

MTHM:

FZP57_07345(hmd)

METJ:

FZP68_03330(hmd)

MRU:	mru_0526(hmd)

MSI:

Msm_0572

MEB:	Abm4_0007(hmd)

MMIL:

sm9_0397(hmd1) sm9_1140(hmd2)

MEYE:

TL18_01650 TL18_01655

MOL:

YLM1_0193

METV:

K4897_03430(hmd)

METT:

CIT01_01065(hmd)

MEME:

HYG87_04865

MFEG:

GCM10025860_14980

MFV:

Mfer_0722

MKA:	MK0013(hmd)

MLA:

Mlab_1744

MPI:

Mpet_2002

MFO:	Metfor_0867

» show all

Reference

Authors

Zirngibl, C., Hedderich, R. and Thauer, R.K.

Title

N5,N10-Methylenetetrahydromethanopterin dehydrogenase from Methanobacterium thermoautotrophicum has hydrogenase activity.

Journal

FEBS Lett 261:112-116 (1990)

Reference

2 [PMID:7628605]

Authors

Klein AR, Fernandez VM, Thauer RK

Title

H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase: mechanism of H2 formation analyzed using hydrogen isotopes.

Journal

FEBS Lett 368:203-6 (1995)
DOI:10.1016/0014-5793(95)00642-M

Other DBs

ExplorEnz - The Enzyme Database:

1.12.98.2

IUBMB Enzyme Nomenclature:

1.12.98.2

ExPASy - ENZYME nomenclature database:

1.12.98.2

BRENDA, the Enzyme Database:

1.12.98.2

CAS:	100357-01-5

LinkDB

DBGET integrated database retrieval system