 | | ENZYME: 1.13.11.25 | |
| Entry |
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| Name |
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase;
steroid 4,5-dioxygenase;
3-alkylcatechol 2,3-dioxygenase;
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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| Sysname |
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (ring-opening)
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| Reaction(IUBMB) |
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate [RN: R04597]
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| Reaction(KEGG) |
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| Substrate |
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione [CPD: C04793];
O2 [CPD: C00007]
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| Product |
3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate [CPD: C04844]
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| Comment |
Requires Fe2+. Also acts on 3-isopropylcatechol and 3-tert-butyl-5-methylcatechol.
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| History |
EC 1.13.11.25 created 1972
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K16049 | 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase |
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| Genes |
| PTAE: | NCTC10697_02092(hsaC) |
| SNAN: | I6N98_01460 I6N98_10755 |
| PPAI: | E1956_37120 E1956_45900 |
| NOT: | C7W88_20680 C7W88_20750 |
| SWI: | Swit_1826 Swit_1848 Swit_3298 |
| SPHD: | HY78_09060 HY78_16340 HY78_16450 |
| SPKC: | KC8_01090 KC8_05325 KC8_16655 KC8_19655 |
| NTD: | EGO55_13435 EGO55_13700 |
| CAEN: | K5X80_14715 K5X80_14970 |
| MBO: | BQ2027_MB3599C(hsac) |
| MCHI: | AN480_02505 AN480_14935 |
| MMAL: | CKJ54_02435 CKJ54_12980(bphC) |
| MMAN: | MMAN_10310 MMAN_21330 MMAN_47960(hsaC) |
| MSA: | Mycsm_04159 Mycsm_05838 |
| MMAE: | MMARE11_48780(bphC) |
| MYV: | G155_04250 G155_26475 |
| MYE: | AB431_15175 AB431_15235 AB431_26550 |
| MSHG: | MSG_02471 MSG_04561(hsaC) |
| MFJ: | MFLOJ_07940 MFLOJ_40670(hsaC) |
| MSTO: | MSTO_09180 MSTO_44620(hsaC) |
| MSIM: | MSIM_29110(hsaC) MSIM_53020 |
| MSAK: | MSAS_05590 MSAS_29150(hsaC) |
| MLW: | MJO58_13015(bphC) MJO58_25090 |
| MXE: | MYXE_05080(hsaC) MYXE_06660 |
| MNV: | MNVI_11570 MNVI_12510(hsaC) |
| MPAG: | C0J29_19280 C0J29_27825 |
| MNM: | MNVM_19350 MNVM_23440(hsaC) |
| MGOR: | H0P51_17855 H0P51_25865 |
| MCOO: | MCOO_26120 MCOO_27310(hsaC) |
| MBAI: | MB901379_04452(hsaC) |
| MSEO: | MSEO_12710 MSEO_34550(hsaC) |
| MHEK: | JMUB5695_00469(hsaC_1) JMUB5695_00575 |
| MGAU: | MGALJ_22850 MGALJ_38560 |
| MBRD: | MBRA_20010(hsaC) MBRA_21120 |
| MMAM: | K3U93_11795(bphC) K3U93_22685 |
| MPAA: | MKK62_02395 MKK62_02910(bphC) |
| MKY: | IWGMT90018_22860 IWGMT90018_57490(hsaC) |
| MWU: | PT015_15055(bphC) PT015_15560 |
| MSM: | MSMEG_2891 MSMEG_6036 |
| MSG: | MSMEI_2817(bphC) MSMEI_5875(bphC) |
| MSB: | LJ00_14380 LJ00_29840 |
| MSN: | LI99_14385 LI99_29845 |
| MSH: | LI98_14390 LI98_29850 |
| MSP: | Mspyr1_39490 Mspyr1_47020 |
| MCB: | Mycch_1590 Mycch_4673 |
| MFT: | XA26_08070 XA26_53610 |
| MPHL: | MPHLCCUG_00493(hsaC_1) MPHLCCUG_02627(hsaC_2) |
| MLL: | B1R94_12250 B1R94_20085 B1R94_25460 |
| MRH: | MycrhN_2245 MycrhN_4259 |
| MTHN: | 4412656_00959(bphC) 4412656_04092(hsaC) |
| MHAS: | MHAS_02457(hsaC_1) MHAS_03777(hsaC_2) |
| MDU: | MDUV_26660 MDUV_49010 |
| MCHT: | MCHIJ_12760 MCHIJ_19310 |
| MAUU: | NCTC10437_02739(hsaC_2) NCTC10437_05067(hsaC_3) |
| MMOR: | MMOR_11760 MMOR_26800 |
| MAIC: | MAIC_05180 MAIC_26790 MAIC_26930 |
| MALV: | MALV_29230 MALV_42140 |
| MGAD: | MGAD_01100 MGAD_37680 |
| MHEV: | MHEL_27650 MHEL_50120 MHEL_50220 |
| MSAR: | MSAR_10970 MSAR_41300 MSAR_41350 |
| MANY: | MANY_12800 MANY_33050 |
| MAUB: | MAUB_27090 MAUB_54790 |
| MPHU: | MPHO_14370 MPHO_43380 |
| MMUC: | C1S78_011095(bphC) C1S78_019250(bphC) C1S78_025610 |
| MBOK: | MBOE_04960 MBOE_20110 |
| MFG: | K6L26_05345 K6L26_16790 K6L26_27685(bphC) |
| MFLV: | NCTC10271_00467(hsaC_1) NCTC10271_02187(hsaC_2) |
| MCEE: | MCEL_06120 MCEL_37740 |
| MMON: | EWR22_01690(bphC) EWR22_25460 |
| MHOL: | K3U96_03080 K3U96_09635(bphC) |
| MSEN: | K3U95_12875 K3U95_25510 |
| MPAE: | K0O64_14655(bphC) K0O64_14700(bphC) K0O64_26060 |
| MDF: | K0O62_15785(bphC) K0O62_25965 |
| MCRO: | MI149_15510(bphC) MI149_15560(bphC) MI149_26360 |
| MKR: | MKOR_35330(hsaC) MKOR_36400 |
| MMV: | MYCMA_0047 MYCMA_0298 |
| MABB: | MASS_0078 MASS_0554 |
| MABL: | MMASJCM_0079 MMASJCM_0574 |
| MCHE: | BB28_00370 BB28_02790 |
| MIZ: | BAB75_00670 BAB75_03540 |
| MSAL: | DSM43276_00503(hsaC) |
| MJD: | JDM601_3853(bphC) JDM601_4250(bphC) |
| MTER: | 4434518_03728(bphC) |
| MMIN: | MMIN_06700 MMIN_12530 |
| MHIB: | MHIB_23840 MHIB_31170(hsaC) |
| NFR: | ERS450000_03764(hsaC_1) ERS450000_05815(hsaC_2) |
| NCY: | NOCYR_0501 NOCYR_2418(bphC) |
| NNO: | NONO_c05030(hsaC1) NONO_c44720 NONO_c58760(hsaC2) |
| NSL: | BOX37_02175 BOX37_11855 |
| NSR: | NS506_01260(hsaC) NS506_06778(etbC) |
| NOD: | FOH10_22595 FOH10_28745 |
| NAD: | NCTC11293_01245(hsaC_1) NCTC11293_04394(hsaC_2) |
| NTC: | KHQ06_03675 KHQ06_24085 KHQ06_26960 KHQ06_35110 |
| NHU: | H0264_03850 H0264_34220 |
| NYA: | LTV02_28890 LTV02_38700 |
| NGP: | LTT66_15420 LTT66_28770 |
| NYU: | D7D52_04495 D7D52_09480 |
| RHA: | RHA1_ro02488 RHA1_ro04541(hsaC) RHA1_ro05803 |
| RER: | RER_07570 RER_13780 RER_51660 |
| REY: | O5Y_03680 O5Y_06490 O5Y_24430 |
| REB: | XU06_03920 XU06_06750 XU06_24850 |
| RQI: | C1M55_04160 C1M55_06995(bphC) C1M55_26050(bphC) |
| ROP: | ROP_22150 ROP_44560 ROP_58640 |
| ROA: | Pd630_LPD00993 Pd630_LPD02422 Pd630_LPD06714 |
| RPY: | Y013_19035 Y013_19285 |
| RBY: | CEJ39_05400 CEJ39_05650 CEJ39_21895(bphC) |
| RAV: | AAT18_03975 AAT18_22060 |
| RRZ: | CS378_10115(bphC) CS378_11825(bphC) CS378_19615 |
| RHQ: | IM25_02765 IM25_08885 |
| RHOD: | AOT96_05860 AOT96_14555 AOT96_17390 |
| RRT: | 4535765_00584(hsaC_1) 4535765_00631(hsaC_2) 4535765_04055(hsaC_4) |
| RCR: | NCTC10994_02089(hsaC_1) NCTC10994_02136(hsaC_2) NCTC10994_03239(hsaC_3) NCTC10994_03314(hsaC_4) |
| RTM: | G4H71_04575(bphC) G4H71_07385 G4H71_13740(bphC) |
| RKO: | JWS14_13060(bphC) JWS14_24495 JWS14_31735(bphC) |
| RGO: | KYT97_11700(bphC) KYT97_15280 KYT97_15685(bphC) KYT97_23245 |
| ROZ: | CBI38_00790 CBI38_01330 CBI38_04180 |
| RPSK: | JWS13_12175(bphC) JWS13_20430 JWS13_32825(bphC) |
| RGOR: | NMQ04_02525 NMQ04_02760(bphC) NMQ04_17480(bphC) NMQ04_17845(bphC) NMQ04_22185 |
| REQ: | REQ_01430 REQ_06820 REQ_40140 REQ_43800 |
| PDEF: | P9209_05565(bphC) P9209_29065 |
| GPO: | GPOL_c41080(hsaC) GPOL_c41220 |
| GOQ: | ACH46_03105 ACH46_03245 |
| GTA: | BCM27_04770 BCM27_05115 |
| GOM: | D7316_02454(hsaC_1) D7316_02467(hsaC_2) D7316_02567(hsaC_3) |
| GAV: | C5O27_00855 C5O27_10720(bphC) |
| GOD: | GKZ92_03975 GKZ92_16410(bphC) |
| GJI: | H1R19_04055 H1R19_12675(bphC) |
| GOI: | LK459_05080 LK459_05165(bphC) |
| DLU: | A6035_02405 A6035_03430 |
| DKN: | NHB83_01965 NHB83_02980 |
| TOY: | FO059_01335(bphC) FO059_14005 FO059_16385 |
| SGRF: | SGFS_022200 SGFS_025350 |
| SCAE: | IHE65_04670 IHE65_42050 |
| NDK: | I601_0578(hsaC_1) I601_3468(hsaC_2) |
| NPI: | G7071_12490 G7071_15935 |
| NFC: | KG111_08325 KG111_15390(bphC) |
| PSIM: | KR76_14470 KR76_27095 |
| AMYC: | CU254_10470 CU254_23455 |
| AMYY: | YIM_14460(hsaC1) YIM_36675(hsaC2) |
| DFU: | Dfulv_20760 Dfulv_33640 |
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| Reference |
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| Authors |
Gibson DT, Wang KC, Sih CJ, Whitlock H Jr. |
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| Title |
Mechanisms of steroid oxidation by microorganisms. IX. On the mechanism of ring A cleavage in the degradation of 9,10-seco steroids by microorganisms. |
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| Journal |
J Biol Chem 241:551-9 (1966) |
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| Other DBs |
| UM-BBD (Biocatalysis/Biodegradation Database): | 1.13.11.25 |
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| LinkDB |
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