Entry |
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Name |
4-hydroxymandelate synthase;
4-hydroxyphenylpyruvate dioxygenase II
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Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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Sysname |
(S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
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Reaction(IUBMB) |
4-hydroxyphenylpyruvate + O2 = (S)-4-hydroxymandelate + CO2 [RN: R06632]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.
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History |
EC 1.13.11.46 created 2001
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Pathway |
ec01055 | Biosynthesis of vancomycin group antibiotics |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K16421 | 4-hydroxymandelate synthase |
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Genes |
SRC: | M271_09160 M271_27680 |
SVT: | SVTN_32165 SVTN_32295 |
SPAV: | Spa2297_02915 Spa2297_26610 Spa2297_32985 |
STSI: | A4E84_04200 A4E84_32820 |
SPLU: | LK06_002715 LK06_031630 |
SFK: | KY5_6265c KY5_6719 KY5_7437c |
SKA: | CP970_03010(hppD) CP970_07050(hppD) CP970_09760(hppD) |
SVR: | CP971_02370(hppD) CP971_08110(hppD) |
SFY: | GFH48_02890(hppD) GFH48_36325(hppD) |
STSU: | B7R87_00120 B7R87_00865 |
SCHA: | CP983_01445(hppD) CP983_10855(hppD) |
SATA: | C5746_00990(hppD) C5746_42245(hppD) |
SINE: | KI385_01575(hppD) KI385_38530(hppD) |
SNIG: | HEK616_29510 HEK616_51390 HEK616_51650 |
SENG: | OJ254_30510(hppD) OJ254_30635(hppD) |
KIS: | HUT16_30870 HUT16_31070(hppD) HUT16_31790(hppD) |
STRH: | GXP74_15495(hppD) GXP74_26090(hppD) |
AGRA: | AGRA3207_002325 AGRA3207_007458 |
NGN: | LCN96_07790(hppD) LCN96_24325(hppD) |
AMYB: | BKN51_28930 BKN51_41520 |
AORI: | SD37_16610 SD37_33645 |
AROO: | NQK81_15410(hppD) NQK81_30300(hppD) |
SSYI: | EKG83_29580(hppD) EKG83_30955(hppD) |
KUT: | JJ691_47820 JJ691_70350 |
STP: | Strop_2490 Strop_2727 |
MFEU: | H1D33_22995(hppD) H1D33_24960(hppD) |
PRY: | Prubr_36840 Prubr_65200 |
DVC: | Dvina_13810(hppD) Dvina_18685(hppD) |
» show all
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Reference |
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Authors |
Hubbard BK, Thomas MG, Walsh CT |
Title |
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics. |
Journal |
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Sequence |
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Reference |
2 |
Authors |
Choroba, O.W., Williams, D.H. and Spencer, J.B. |
Title |
Biosynthesis of the vancomycin group of antibiotics: involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine. |
Journal |
J Am Chem Soc 122:5389-5390 (2000) |
Other DBs |
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LinkDB |
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