KEGG   ENZYME: 1.13.12.9
Entry
EC 1.13.12.9                Enzyme                                 
Name
phenylalanine 2-monooxygenase;
L-phenylalanine oxidase (deaminating and decarboxylating);
phenylalanine (deaminating, decarboxylating)oxidase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
Sysname
L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O [RN:R00690]
Reaction(KEGG)
R00690
Substrate
L-phenylalanine [CPD:C00079];
O2 [CPD:C00007]
Product
2-phenylacetamide [CPD:C02505];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
The reaction shown above is about 80% of the reaction catalysed; the remaining 20% is: L-phenylalanine + O2 + H2O = 3-phenylpyruvic acid + ammonia + H2O2 a reaction similar to that of EC 1.4.3.2, L-amino-acid oxidase.
History
EC 1.13.12.9 created 1986, modified 2003
Pathway
ec00360  Phenylalanine metabolism
ec01100  Metabolic pathways
Orthology
K21795  phenylalanine 2-monooxygenase
Genes
PCHPC4K32_4297
PDWBV82_3963
RSORSc3151
RSEF504_3173
RPUCDC45_16105
RNCGO999_01135
RSCRCFBP_10283
RSLRPSI07_0329
RSNRSPO_c00326
RSMCMR15_10247
RSYRSUY_03050
RSGJK151_03085
BCEPAPZ15_35535
PGISI6I06_02560
ACHBDVB37_02190
 » show all
Reference
1  [PMID:7174643]
  Authors
Koyama H
  Title
Purification and characterization of a novel L-phenylalanine oxidase (Deaminating and decarboxylating) from Pseudomonas sp. P-501.
  Journal
J Biochem 92:1235-40 (1982)
DOI:10.1093/oxfordjournals.jbchem.a134041
  Sequence
Reference
2  [PMID:6501250]
  Authors
Koyama H.
  Title
Oxidation and oxygenation of L-amino acids catalyzed by a L-phenylalanine oxidase (deaminating and decarboxylating) from Pseudomonas sp. P-501.
  Journal
J Biochem (Tokyo) 96:421-7 (1984)
DOI:10.1093/oxfordjournals.jbchem.a134853
  Sequence
Reference
3  [PMID:6692570]
  Authors
Koyama H.
  Title
A simple and rapid enzymatic determination of L-phenylalanine with a novel L-phenylalanine oxidase (deaminating and decarboxylating) from Pseudomonas sp. P-501.
  Journal
Clin Chim Acta 136:131-6 (1984)
DOI:10.1016/0009-8981(84)90284-5
Reference
4  [PMID:3818566]
  Authors
Koyama H, Suzuki H.
  Title
Spectral and kinetic studies on Pseudomonas L-phenylalanine oxidase (deaminating and decarboxylating).
  Journal
J Biochem (Tokyo) 100:859-66 (1986)
DOI:10.1093/oxfordjournals.jbchem.a121798
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.12.9
IUBMB Enzyme Nomenclature: 1.13.12.9
ExPASy - ENZYME nomenclature database: 1.13.12.9
BRENDA, the Enzyme Database: 1.13.12.9
CAS: 190396-37-3
LinkDB

DBGET integrated database retrieval system