KEGG ENZYME: 1.14.11.10

ENZYME: 1.14.11.10

Entry

EC 1.14.11.10               Enzyme

Name

pyrimidine-deoxynucleoside 1'-dioxygenase;
deoxyuridine-uridine 1'-dioxygenase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Sysname

2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)

Reaction(IUBMB)

2'-deoxyuridine + 2-oxoglutarate + O2 = uracil + 2-deoxyribonolactone + succinate + CO2 [RN:R02486]

Reaction(KEGG)

R02486

Substrate

2'-deoxyuridine [CPD:C00526];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Product

uracil [CPD:C00106];
2-deoxyribonolactone [CPD:C02674];
succinate [CPD:C00042];
CO2 [CPD:C00011]

Comment

Requires iron(II) and ascorbate. cf. EC 1.14.11.3, pyrimidine-deoxynucleoside 2'-dioxygenase.

History

EC 1.14.11.10 created 1989, modified 2002

Reference

1 [PMID:4040518]

Authors

Stubbe J.

Title

Identification of two alpha-ketoglutarate-dependent dioxygenases in extracts of Rhodotorula glutinis catalyzing deoxyuridine hydroxylation.

Journal

J Biol Chem 260:9972-5 (1985)

Other DBs

ExplorEnz - The Enzyme Database:

1.14.11.10

IUBMB Enzyme Nomenclature:

1.14.11.10

ExPASy - ENZYME nomenclature database:

1.14.11.10

BRENDA, the Enzyme Database:

1.14.11.10

CAS:	98865-52-2

LinkDB

DBGET integrated database retrieval system