Entry
Name
anthranilate 3-monooxygenase (deaminating);
anthranilate hydroxylase;
anthranilate 2,3-dioxygenase (deaminating);
anthranilate hydroxylase (deaminating);
anthranilic hydroxylase;
anthranilate 2,3-hydroxylase (deaminating)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)
Reaction(IUBMB)
anthranilate + NADPH + H+ + O2 = 2,3-dihydroxybenzoate + NADP+ + NH3 [RN:
R00980 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme from Aspergillus niger is an iron protein; that from the yeast Trichosporon cutaneum is a flavoprotein (FAD).
History
EC 1.14.13.35 created 1972 as EC 1.14.12.2, transferred 1990 to EC 1.14.13.35
Pathway
Reference
Authors
Powlowski JB, Dagley S, Massey V, Ballou DP.
Title
Properties of anthranilate hydroxylase (deaminating), a flavoprotein from Trichosporon cutaneum.
Journal
J Biol Chem 262:69-74 (1987)
Reference
Authors
Subramanian V, Vaidyanathan CS.
Title
Anthranilate hydroxylase from Aspergillus niger: new type of NADPH-linked nonheme iron monooxygenase.
Journal
Other DBs
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.35
LinkDB
All DBs