KEGG   ENZYME: 1.14.13.43
Entry
EC 1.14.13.43               Enzyme                                 
Name
questin monooxygenase;
questin oxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)
Reaction(IUBMB)
questin + NADPH + H+ + O2 = demethylsulochrin + NADP+ [RN:R02417]
Reaction(KEGG)
R02417
Substrate
questin [CPD:C01448];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
demethylsulochrin [CPD:C15504];
NADP+ [CPD:C00006]
Comment
The enzyme cleaves the anthraquinone ring of questin to form a benzophenone. Involved in the biosynthesis of the seco-anthraquinone (+)-geodin.
History
EC 1.14.13.43 created 1992
Reference
1  [PMID:3182756]
  Authors
Fujii I, Ebizuka Y, Sankawa U.
  Title
A novel anthraquinone ring cleavage enzyme from Aspergillus terreus.
  Journal
J Biochem (Tokyo) 103:878-83 (1988)
DOI:10.1093/oxfordjournals.jbchem.a122365
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.43
IUBMB Enzyme Nomenclature: 1.14.13.43
ExPASy - ENZYME nomenclature database: 1.14.13.43
BRENDA, the Enzyme Database: 1.14.13.43
CAS: 115232-45-6
LinkDB

DBGET integrated database retrieval system