KEGG   ENZYME: 1.2.1.51
Entry
EC 1.2.1.51                 Enzyme                                 
Name
pyruvate dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)
Reaction(IUBMB)
pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH [RN:R00210]
Reaction(KEGG)
R00210
Substrate
pyruvate [CPD:C00022];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
acetyl-CoA [CPD:C00024];
CO2 [CPD:C00011];
NADPH [CPD:C00005]
Comment
The Euglena enzyme can also use FAD or methyl viologen as acceptor, more slowly. The enzyme is inhibited by oxygen.
History
EC 1.2.1.51 created 1989
Orthology
K21682  pyruvate dehydrogenase (NADP+)
Genes
LAK106179427
CPVcgd4_690
SMINv1.2.029520.t1(symbB.v1.2.029520.t1) v1.2.029521.t1(symbB.v1.2.029521.t1)
GTTGUITHDRAFT_159505
Reference
1  [PMID:6438078]
  Authors
Inui H, Miyatake K, Nakano Y, Kitaoka S.
  Title
Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis.
  Journal
J Biochem (Tokyo) 96:931-4 (1984)
DOI:10.1093/oxfordjournals.jbchem.a134913
Reference
2  [PMID:3110154]
  Authors
Inui H, Ono K, Miyatake K, Nakano Y, Kitaoka S
  Title
Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis.
  Journal
J Biol Chem 262:9130-5 (1987)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.51
IUBMB Enzyme Nomenclature: 1.2.1.51
ExPASy - ENZYME nomenclature database: 1.2.1.51
BRENDA, the Enzyme Database: 1.2.1.51
CAS: 93389-35-6
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