KEGG ENZYME: 1.2.1.54

ENZYME: 1.2.1.54

Entry

EC 1.2.1.54                 Enzyme

Name

gamma-guanidinobutyraldehyde dehydrogenase;
alpha-guanidinobutyraldehyde dehydrogenase;
4-guanidinobutyraldehyde dehydrogenase;
GBAL dehydrogenase

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

4-guanidinobutanal:NAD+ 1-oxidoreductase

Reaction(IUBMB)

4-guanidinobutanal + NAD+ + H2O = 4-guanidinobutanoate + NADH + 2 H+ [RN:R03177]

Reaction(KEGG)

R03177

Substrate

4-guanidinobutanal [CPD:C02647];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

Product

4-guanidinobutanoate [CPD:C01035];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Involved in the degradation of arginine in Pseudomonas putida (cf. EC 1.2.1.19 aminobutyraldehyde dehydrogenase).

History

EC 1.2.1.54 created 1989

Pathway

ec00330

Arginine and proline metabolism

ec01100

Metabolic pathways

Orthology

K12254

4-guanidinobutyraldehyde dehydrogenase / NAD-dependent aldehyde dehydrogenase

Genes

SLQ:	M495_12010

XAL:

XALC_2105

XSA:	SB85_04725

XTN:	FD63_11895

XHY:	FZ025_01015

XTH:	G4Q83_09765

XAG:	HEP73_01654

XAS:	HEP74_01590

SML:	Smlt1571(aldH)

SMT:

Smal_1330

BUJ:	BurJV3_1321

SMZ:	SMD_1402(aldH)

STEK:

AXG53_02925

SLM:	BIZ42_15785

STEN:

CCR98_07065

STEM:

CLM74_07570

STES:

MG068_06680

SINC:

DAIF1_14150(puuC)

SPAQ:

STNY_R14500

SGEN:

RKE57_07110

PSU:	Psesu_2109

PSUW:

WQ53_02590

PSD:

DSC_07485

PMEX:

H4W19_01045

PJP:	LAG73_10865

PDD:	MNQ95_01565

XBA:	C7S18_09045

VNA:	PN96_08640

VEJ:	VEJY3_04415

VBR:	A6E01_17925

VSH:	BSZ05_23820

PAE:

PA5312

PAEV:

N297_5492

PAEI:

N296_5492

PAU:	PA14_70140(aldH)

PAP:	PSPA7_6087

PAG:	PLES_57071

PAF:	PAM18_5432

PNC:	NCGM2_6076(aldH)

PAEB:

NCGM1900_6154(aldH)

PDK:	PADK2_28295

PSG:	G655_27960

PRP:	M062_27985

PAEP:

PA1S_28715

PAER:

PA1R_gp3244

PAEM:

U769_29220

PAEL:

T223_29175

PAES:

SCV20265_6037

PAEU:

BN889_05891

PAEG:

AI22_05275

PAEC:

M802_5490

PAEO:

M801_5357

PMY:

Pmen_0237

PMK:

MDS_0290

PRE:	PCA10_27210 PCA10_49530 PCA10_55150

PPSE:

BN5_0159

PFUW:

KF707C_14160 KF707C_55600

PALC:

A0T30_00975

PCQ:	PcP3B5_54750(puuC_3) PcP3B5_60480(puuC_4)

PMUI:

G4G71_03995 G4G71_07100 G4G71_18480

PNT:	G5B91_19970 G5B91_28330 G5B91_31375

PPAA:

B7D75_27530

PPU:	PP_5278(kauB)

PPF:

Pput_5188

PPG:	PputGB1_5330

PPW:	PputW619_0192

PPT:	PPS_2244 PPS_5130

PPB:	PPUBIRD1_5072

PPI:

YSA_04677

PPX:

T1E_2789

PPUH:

B479_26140

PPUT:

L483_31550

PPUN:

PP4_53430

PPUD:

DW66_2502 DW66_5700

PFV:	Psefu_0701 Psefu_1405

PMON:

X969_09550 X969_25350

PMOT:

X970_09210 X970_24985

PPJ:	RK21_02588 RK21_04912

POR:	APT59_12895 APT59_20985

PMOL:

CLJ08_13550

PALD:

LU682_028750

PIX:	RIN61_11250

PMOS:

O165_022555

PST:	PSPTO_0092

PSB:

Psyr_0227

PSYR:

N018_00480

PSP:	PSPPH_0215

PSAV:

PSA3335_25755

PAMG:

BKM19_002630

PCI:	PCH70_01610

PAVL:

BKM03_00625

PVD:	CFBP1590_0205(puuC)

PCAB:

JGS08_00095

PCOF:

POR16_00110

PTRE:

I9H09_00100

PSYI:

MME58_00795

PAST:

N015_00100

PLIJ:

KQP88_00775

PFL:	PFL_2342(puuC) PFL_6046

PPRC:

PFLCHA0_c24080(puuC1) PFLCHA0_c60050(puuC4)

PPRO:

PPC_2386 PPC_5999

PFE:	PSF113_5754

PFN:	HZ99_16915

PFO:	Pfl01_2123 Pfl01_5534(aldH)

PFS:	PFLU_5976(aldH)

PFC:	PflA506_5260

PPZ:	H045_20190

PFB:

VO64_2867

PMAN:

OU5_3622 OU5_5944

PTV:	AA957_15240

PCG:	AXG94_14440

PVR:	PverR02_14435 PverR02_30560

PAZO:

AYR47_06040

POI:	BOP93_25560

PRX:	HRH33_00080

PMED:

E3Z27_27465

PKR:	AYO71_00935 AYO71_19055

PMUD:

NCTC8068_03380(puuC_2) NCTC8068_05254(puuC_3)

PTOL:

I7845_28180

PFW:	PF1751_v1c53900

PFF:	PFLUOLIPICF709040

PFX:	A7318_26575

PEN:	PSEEN5424(aldH)

PLUL:

FOB45_23600

PBA:	PSEBR_a2310 PSEBR_a5516

PBC:	CD58_28845

PPUU:

PputUW4_03104(puuC1) PputUW4_05318

PDR:	H681_24150

PSV:	PVLB_25000

PSK:	U771_30880

PKC:	PKB_5073(puuc3) PKB_5650(puuc5)

PCH:	EY04_10805 EY04_30395

PCZ:	PCL1606_01530 PCL1606_38200

PCP:	JM49_01075 JM49_19095

PCHP:

C4K32_2324 C4K32_6124

PFZ:	AV641_00450

PLQ:	AA042_09885

PALK:

PSAKL28_42000 PSAKL28_51430 PSAKL28_51610

PRH:	LT40_16840

PSW:	LK03_05475

PPV:	NJ69_18350

PSES:

PSCI_1602 PSCI_2655

PSEM:

TO66_11630 TO66_30790

PSEC:

CCOS191_5174(puuC3)

PPSY:

AOC04_20625

PSOS:

POS17_2330 POS17_6003

PFK:	PFAS1_11970 PFAS1_28370

PANR:

A7J50_5711

PPSL:

BJP27_05655 BJP27_15490

PSET:

THL1_5607

PSIL:

PMA3_16500 PMA3_26340 PMA3_29440

PYM:	AK972_6098

PKE:	DLD99_11280 DLD99_28095

PALL:

UYA_01070

PUM:	HGP31_00075 HGP31_17740

POJ:	PtoMrB4_01710

PGG:	FX982_01624

PPSH:

G5J76_03680 G5J76_23635

PGY:	AWU82_07295 AWU82_18205

PLAL:

FXN65_27120

PSEJ:

HNQ25_00150

PVK:	EPZ47_28935

PEZ:	HWQ56_01085

PBZ:	GN234_19120

PKH:	JLK41_01080

PTY:	JWV26_11845

PMAO:

PMYSY11_4277(puuC)

PATA:

JWU58_01495 JWU58_11215

PDW:	BV82_2161 BV82_2182

PZE:	HU754_000100 HU754_012300

PMOE:

HV782_000100 HV782_017720

PCAM:

HNE05_18800

PSEP:

C4K39_2239 C4K39_3616

PPII:

QL104_12325 QL104_30595

PVW:	HU752_000120 HU752_022010

PTRT:

HU722_0000080

PXA:	KSS93_02605

PSAM:

HU731_015175

PTZ:	HU718_000080 HU718_018450

PQI:	KH389_26480

PSHH:

HU773_000080

PXN:	HU772_024300

PHV:	HU739_006950 HU739_018615

PPRG:

HU725_013470 HU725_013520 HU725_022255

PANH:

HU763_023980

PASG:

KSS96_00080

PFAK:

KSS94_26470

PMUY:

KSS95_03685

PMAM:

KSS90_24850

PAZE:

KSS91_00080 KSS91_17130

PALV:

KSS97_00095 KSS97_16895

PORY:

EJA05_27470

PWZ:	J7655_01500

PTK:	EXN22_00850 EXN22_00945

PTW:	TUM18999_01970

PZA:	HU749_000080

PIE:	HU724_000095 HU724_017445

PWY:	HU734_000270

PTAE:

NCTC10697_00088(puuC_1)

PGF:	J0G10_00080 J0G10_18400

PCAV:

D3880_03855 D3880_21725

PJU:	L1P09_24630

PHF:	NLY38_01235

PPHN:

HU825_04505

PIZ:	LAB08_R23230 LAB08_R33490 LAB08_R58990

PPEG:

KUA23_29245

PSII:

NF676_16325 NF676_26640

PSIH:

LOY51_26275

PCAS:

LOY40_16170 LOY40_28390

PFIT:

KJY40_00080 KJY40_12450

PASI:

LG197_04255 LG197_16540

PKM:	PZ739_27170

PNB:	NK667_07980 NK667_28360

PSOA:

PSm6_21910

PTAI:

ICN73_07020

PKK:	QQ992_27420

PKJ:	Q1W70_01055 Q1W70_10975

PHYG:

JTY93_26695

PHOM:

KJF94_13680 KJF94_25735

PCHE:

QYM18_08900

PCUC:

PSH97_11730 PSH97_27395

PTRL:

OU419_24430 OU419_27710

PPAE:

LDL65_10345

PPAO:

K3169_00275

PRHZ:

CRX69_00235

PSJY:

AA098_00580

PSKU:

KUIN1_02270

PSA:

PST_0046

PSZ:	PSTAB_0055

PSR:	PSTAA_0048

PSC:	A458_21210

PSJ:	PSJM300_18690

PSH:	Psest_4305

PSTT:

CH92_21230

PSTU:

UIB01_21885

PSED:

DM292_18945

PCHL:

LLJ08_20635

PBM:	CL52_00880

PKG:	LW136_22230

SDEG:

GOM96_09875

PZD:	KQ248_05070

AVN:	Avin_48030(aldH)

AVL:	AvCA_48030(aldH)

AVD:	AvCA6_48030(aldH)

ACX:	Achr_37390(aldH)

PAGR:

E2H98_17455

EAZ:	JHT90_05775

HAES:

LO767_18120

PDEN:

F1C79_19855 F1C79_23320

HARR:

HV822_10155

PNN:	KEM63_00705

PPHA:

BVH74_02395 BVH74_04525

PBAU:

OS670_13505

MANP:

EHN06_09995

MSAN:

LPB19_00910

THAP:

FNC98_01145

ASQ:	AVL57_01780

AAW:	AVL56_00590

ALE:	AV939_00595

ALZ:	AV940_00595

LAL:	AT746_07175

AGZ:	M0C34_01445

AGQ:	LQZ07_01320

FBL:

Fbal_1146

SAGA:

M5M_11425

OSG:	BST96_18805

MTHD:

A3224_14415

MICC:

AUP74_00575(puuC)

MAGA:

Mag101_02170

MII:	BTJ40_20510

MICT:

FIU95_19470(puuC)

MHYD:

GTQ55_02575

MCEL:

LPW13_13965

MICZ:

GL2_16830

MVB:	MJO52_19620

MPAF:

R5R33_11560

MBRG:

PVT68_13885

HJA:	BST95_16365

BLEP:

AL038_06330

APRS:

BI364_04885

AAEO:

BJI67_05375

AFY:	BW247_14575

HNA:	Hneap_2372

HAZ:	A9404_08905

CCAG:

SR908_13550

HCS:	FF32_03760

HHU:	AR456_12110

HCO:	LOKO_02562(puuC)

HSI:	BOX17_02020

HALO:

BWR19_12470

HBE:

BEI_1148

HAF:	C8233_07745

HSV:	HNO53_13995 HNO53_14025

HPRO:

LMS44_20075 LMS44_20140

HQD:	K1Y77_14075

HBH:	E4T21_11505

HALF:

QEN58_17420 QEN58_17500

HHAO:

QWG60_11175

HASO:

B2G49_15450

HALW:

B6N23_04640

HALK:

CUU95_08400

HOL:	HORIV_63030

HCAM:

I4484_13715

HSX:	HNO51_13400 HNO51_13435

HTX:	EKK97_15095 EKK97_15120

CMAI:

BFX80_13800

CAMH:

LCW13_03445

COBE:

CLAM6_06690 CLAM6_14210

COBB:

H2O77_03335 H2O77_07605

PAUR:

FGL86_02075

SAJS:

QO259_03745

MMW:	Mmwyl1_3527

MME:	Marme_3789

MPRI:

MP3633_0006

MARD:

IBG28_15415

MFOI:

JSY38_09295

MPRF:

J8N69_08015

MRHI:

KDW99_00040

MPON:

MACH16_00130

AJP:	AMJAP_2131(kauB)

GSN:	YC6258_05871

RFO:	REIFOR_00600(puuC)

EEI:	NX720_19790

EMP:	EZMO1_3499(puuC)

AHY:	AHML_01190

AHD:	AI20_18260

AHR:	V428_01300

AHP:	V429_01300

AHJ:	V469_22020

AHH:	RY45_01495

AHI:	VU14_21275

AAJ:	BOQ57_01100

ASA:

ASA_4155

AEO:	O23A_p3467

AVR:

B565_3831

AVO:	AMS64_22450

AMED:

B224_5460

ASR:	WL1483_1298(puuC)

ADH:	CK627_04995

ACAV:

VI35_20215

AEM:	CK911_16265

AEA:	C2U39_00445

ARV:	C7N77_03345

AES:	C2U30_15490

AEL:	NCTC12917_04090(puuC)

ASIM:

FE240_16545

AALL:

I6G90_16870

AJD:	I6H43_09870

ARIV:

KYK33_00735

ASAA:

KXJ75_00990

AEJ:	E5E97_05430

ABES:

IU367_00845

OCE:

GU3_00195

OPE:	PU634_00570

ZDF:	AN401_16830

VFF:	VITFI_CDS2202

BMK:

DM80_3359

PWU:	A8O14_01650

PLG:	NCTC10937_00050(puuC_1)

HYF:	DTO96_100783(puuC)

RSB:	RS694_08970

RHG:	EXZ61_10805

HYB:

Q5W_22305

HYL:	LPB072_14535

HYC:	E5678_17025

HPSE:

HPF_00630(puuC)

HYN:	F9K07_01105

HTN:	KI616_00570

HCZ:	G9Q37_17535

CBAB:

SMCB_2218

HGR:	DW355_03945

PBH:	AAW51_2992(puuC)

METP:

C1M51_18070

RGE:	RGE_26320(aldH)

RBN:	RBXJA2T_08640

KIA:	G8A07_16370

PKT:	AT984_07330

PAQA:

K9V56_012755

MIU:	ABE85_07415

IDC:	LRM40_09610

ATER:

MW290_01440 MW290_13085

LCH:

Lcho_1737

RGU:	A4W93_11120

JAG:

GJA_494

JAZ:	YQ44_01245

JAL:	BZG29_26390

JSV:	CNX70_26655

JAS:	FJQ89_15855

JLV:	G3257_27055

JAH:	JAB4_054280(puuC)

JRI:	P9875_27455

MNR:	ACZ75_21885

MASW:

AM586_25595

MASS:

CR152_10820

MASY:

DPH57_17665

MANC:

IV454_04605

MVAR:

MasN3_47420

MENY:

LSQ66_19005

MLIR:

LPB04_07985

MASZ:

C9I28_04250

MALI:

EYF70_00885

MUM:	FCL38_17665

MFLA:

GO485_13095

MPLI:

E1742_13605

TCT:	PX653_18795

DUG:	HH213_07950

DZO:	SR858_01135

TMJ:	P0M04_11605

RUG:	QC826_01385

EHB:	E7V67_001365

UPV:	EJN92_19140 EJN92_19890

UPI:	EJG51_002325

TIN:

Tint_0186

AON:	DEH84_16845

TTW:	LCC91_12220

ETB:	N7L95_01145

MEH:

M301_1070

MPAU:

ZMTM_12870

SNIV:

SFSGTM_03300

NIV:	JY500_13490

MESR:

FGU64_15350

PHT:	BLM14_27650

KMN:	HW532_02065

SIX:

BSY16_55

EAD:	OV14_b1223

ARA:	Arad_8305(dhaL)

SOJ:	K6301_18370

SSUM:

Q9314_21520

MET:

M446_3859

AALA:

IGS74_16035

NOH:	G5V57_27715

HAT:	RC74_13670

RSH:	Rsph17029_3176

RSQ:	Rsph17025_2836

RSK:	RSKD131_3700

RCP:	RCAP_rcc02448(aldH2)

PKD:	F8A10_04085

SINR:

O5O51_10465

CBOT:

ATE48_09385

NOT:	C7W88_16550

SECH:

B18_09235

SLAA:

EUU25_08920

RCE:	RC1_1452(puuC)

RPM:	RSPPHO_00962

HJO:	AY555_10510

HTQ:	FRZ44_30230 FRZ44_49550

HADH:

FRZ61_17290 FRZ61_48100

TXI:

TH3_10790

THAC:

CSC3H3_10525

TII:	DY252_13700

THAI:

IT893_07555

TLU:	R1T41_19625

TTB:	MACH01_15090

VSU:	P3M64_12510

ECOG:

FIV45_11445 FIV45_12470

PAQI:

KW060_01045

PARH:

I5S86_01675 I5S86_17340

CLB:	Clo1100_0596

MDF:	K0O62_08615

RPSK:

JWS13_05535

SVL:	Strvi_4312

SRC:	M271_03755

SMAL:

SMALA_7627

SCHA:

CP983_06230

SVD:	CP969_21125

SCAE:

IHE65_42420

RLA:	Rhola_00000830

ASOI:

MTP13_00115

LLUT:

K1X41_04045

NARO:

CFH99_04475

SGRG:

L0C25_20690

SPIQ:

OHA34_05055

TBI:

Tbis_1741

AMN:

RAM_31850

AMM:	AMES_6118(puuC)

AMZ:	B737_6118(puuC)

RRD:	RradSPS_2074

» show all

Reference

Authors

Yorifuji, T., Koike, K., Sakurai, T. and Yokoyama, K.

Title

4-Aminobutyraldehyde and 4-guanidinobutyraldehyde dehydrogenases for arginine degradation in Pseudomonas putida.

Journal

Agric Biol Chem 50:2009-2016 (1986)

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.54

IUBMB Enzyme Nomenclature:

1.2.1.54

ExPASy - ENZYME nomenclature database:

1.2.1.54

BRENDA, the Enzyme Database:

1.2.1.54

CAS:	56831-75-5

LinkDB

DBGET integrated database retrieval system