KEGG   ENZYME: 1.2.1.74
Entry
EC 1.2.1.74                 Enzyme                                 
Name
abieta-7,13-dien-18-al dehydrogenase;
abietadienal dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
abieta-7,13-dien-18-al:NAD+ oxidoreductase
Reaction(IUBMB)
abieta-7,13-dien-18-al + H2O + NAD+ = abieta-7,13-dien-18-oate + NADH + H+ [RN:R06357]
Reaction(KEGG)
R06357
Substrate
abieta-7,13-dien-18-al [CPD:C11887];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
abieta-7,13-dien-18-oate [CPD:C06087];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Abietic acid is the principle component of conifer resin. This enzyme catalyses the last step of the pathway of abietic acid biosynthesis in Abies grandis (grand fir). The activity has been demonstrated in cell-free stem extracts of A. grandis, was present in the cytoplasm, and required NAD+ as cofactor [1]. The enzyme is expressed constitutively at a high level, and is not inducible by wounding of the plant tissue [2].
History
EC 1.2.1.74 created 2009, modified 2012
Pathway
ec00904  Diterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:8311462]
  Authors
Funk C, Croteau R
  Title
Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis.
  Journal
Arch Biochem Biophys 308:258-66 (1994)
DOI:10.1006/abbi.1994.1036
Reference
2  [PMID:12232380]
  Authors
Funk C, Lewinsohn E, Vogel BS, Steele CL, Croteau R
  Title
Regulation of Oleoresinosis in Grand Fir (Abies grandis) (Coordinate Induction of Monoterpene and Diterpene Cyclases and Two Cytochrome P450-Dependent Diterpenoid Hydroxylases by Stem Wounding).
  Journal
Plant Physiol 106:999-1005 (1994)
DOI:10.1104/pp.106.3.999
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.74
IUBMB Enzyme Nomenclature: 1.2.1.74
ExPASy - ENZYME nomenclature database: 1.2.1.74
BRENDA, the Enzyme Database: 1.2.1.74
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