Entry |
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Name |
isopenicillin-N synthase;
isopenicillin N synthetase
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Class |
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With oxygen as acceptor
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Sysname |
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)
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Reaction(IUBMB) |
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O
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Reaction(KEGG) |
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Substrate |
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine;
O2 [CPD: C00007]
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Product |
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Comment |
Forms part of the penicillin biosynthesis pathway (for pathway, click here).
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History |
EC 1.21.3.1 created 2002
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Pathway |
ec00311 | Penicillin and cephalosporin biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K04126 | isopenicillin-N synthase |
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Genes |
» show all
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Reference |
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Authors |
Huffman GW, Gesellchen PD, Turner JR, Rothenberger RB, Osborne HE, Miller FD, Chapman JL, Queener SW. |
Title |
Substrate specificity of isopenicillin N synthase. |
Journal |
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Reference |
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Authors |
Roach PL, Clifton IJ, Fulop V, Harlos K, Barton GJ, Hajdu J, Andersson I, Schofield CJ, Baldwin JE |
Title |
Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.21.3.1 |
ExPASy - ENZYME nomenclature database: | 1.21.3.1 |
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LinkDB |
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