KEGG   ENZYME: 1.3.3.10
Entry
EC 1.3.3.10                 Enzyme                                 
Name
tryptophan alpha,beta-oxidase;
L-tryptophan 2',3'-oxidase;
L-tryptophan alpha,beta-dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With oxygen as acceptor
Sysname
L-tryptophan:oxygen alpha,beta-oxidoreductase
Reaction(IUBMB)
L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2 [RN:R05317]
Reaction(KEGG)
R05317
Substrate
L-tryptophan [CPD:C00078];
O2 [CPD:C00007]
Product
alpha,beta-didehydrotryptophan [CPD:C06732];
H2O2 [CPD:C00027]
Comment
Requires heme. The enzyme from Chromobacterium violaceum is specific for tryptophan derivatives possessing its carboxyl group free or as an amide or ester, and an unsubstituted indole ring. Also catalyses the alpha,beta dehydrogenation of L-tryptophan side chains in peptides. The product of the reaction can hydrolyse spontaneously to form (indol-3-yl)pyruvate.
History
EC 1.3.3.10 created 2000 as EC 1.4.3.17, transferred 2003 to EC 1.3.3.10
Reference
1  [PMID:8027079]
  Authors
Genet R, Denoyelle C, Menez A.
  Title
Purification and partial characterization of an amino acid alpha,beta- dehydrogenase, L-tryptophan 2',3'-oxidase from Chromobacterium violaceum.
  Journal
J Biol Chem 269:18177-84 (1994)
Reference
2  [PMID:7559518]
  Authors
Genet R, Benetti PH, Hammadi A, Menez A.
  Title
L-tryptophan 2',3'-oxidase from Chromobacterium violaceum. Substrate specificity and mechanistic implications.
  Journal
J Biol Chem 270:23540-5 (1995)
DOI:10.1074/jbc.270.40.23540
Other DBs
ExplorEnz - The Enzyme Database: 1.3.3.10
IUBMB Enzyme Nomenclature: 1.3.3.10
ExPASy - ENZYME nomenclature database: 1.3.3.10
BRENDA, the Enzyme Database: 1.3.3.10
CAS: 156859-19-7
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