Entry |
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Name |
6-hydroxynicotinate reductase;
6-oxotetrahydronicotinate dehydrogenase;
6-hydroxynicotinic reductase;
HNA reductase;
1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase
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Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
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Sysname |
6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase
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Reaction(IUBMB) |
6-oxo-1,4,5,6-tetrahydronicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin [RN: R03164]
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Reaction(KEGG) |
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Substrate |
6-oxo-1,4,5,6-tetrahydronicotinate [CPD: C04226];
oxidized ferredoxin [CPD: C00139]
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Product |
6-hydroxynicotinate [CPD: C01020];
reduced ferredoxin [CPD: C00138]
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History |
EC 1.3.7.1 created 1972
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Pathway |
ec00760 | Nicotinate and nicotinamide metabolism |
ec01120 | Microbial metabolism in diverse environments |
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Orthology |
K20449 | 6-hydroxynicotinate reductase |
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Genes |
SPSE: | SULPSESMR1_04043(hnr) |
» show all
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Reference |
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Authors |
Holcenberg JS, Tsai L |
Title |
Nicotinic acid metabolism. IV. Ferredoxin-dependent reduction of 6-hydroxynicotinic acid to 6-oxo-1,4,5,6-tetrahydronicotinic acid. |
Journal |
J Biol Chem 244:1204-11 (1969) |
Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.3.7.1 |
ExPASy - ENZYME nomenclature database: | 1.3.7.1 |
BRENDA, the Enzyme Database: | 1.3.7.1 |
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LinkDB |
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