KEGG   ENZYME: 1.4.1.14
Entry
EC 1.4.1.14                 Enzyme                                 
Name
glutamate synthase (NADH);
glutamate (reduced nicotinamide adenine dinucleotide) synthase;
NADH: GOGAT;
L-glutamate synthase (NADH);
L-glutamate synthetase;
NADH-glutamate synthase;
NADH-dependent glutamate synthase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-glutamate:NAD+ oxidoreductase (transaminating)
Reaction(IUBMB)
2 L-glutamate + NAD+ = L-glutamine + 2-oxoglutarate + NADH + H+ [RN:R00093];
(1a) L-glutamate + NH3 = L-glutamine + H2O [RN:R00256];
(1b) L-glutamate + NAD+ + H2O = NH3 + 2-oxoglutarate + NADH + H+ [RN:R00243]
Reaction(KEGG)
Substrate
L-glutamate [CPD:C00025];
NAD+ [CPD:C00003];
NH3 [CPD:C00014];
H2O [CPD:C00001]
Product
L-glutamine [CPD:C00064];
2-oxoglutarate [CPD:C00026];
NADH [CPD:C00004];
H+ [CPD:C00080];
H2O [CPD:C00001];
NH3 [CPD:C00014]
Comment
A flavoprotein (FMN). The reaction takes place in the direction of L-glutamate production. The protein is composed of two domains, one hydrolysing L-glutamine to NH3 and L-glutamate (cf. EC 3.5.1.2, glutaminase), the other combining the produced NH3 with 2-oxoglutarate to produce a second molecule of L-glutamate (cf. EC 1.4.1.2, glutamate dehydrogenase).
History
EC 1.4.1.14 created 1978, modified 2019
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec00910  Nitrogen metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00264  glutamate synthase (NADH)
Genes
BFO118423229
BBEL109473320
SPU754163
LPIC129258831 129258833 129259375 129259376
AJC117119745
DMEDmel_CG9674(CG9674)
DER6543630
DSE6606013
DSIDsimw501_GD12441(Dsim_GD12441)
DYADyak_GE22188
DAN6493372
DSR110190291
DPO4812304
DPE6601003
DMN108152363
DWI6645095
DGR6557958
DMODmoj_GI11930
DAZ108613420
DNV108650790
DHE111605684
DVI6622079
CCAT101448290
BOD106620726
BDR105232888
RZE108360908 108371738
AOQ129242928
TDA119668579
MDE101893373 131804054
SCAC106092120
LCQ111683468
LSQ119602600
GFS119632430
ECOE129946950
CLON129610451 129618227
HIS119650296
AGA1276969
ACOZ120951886
AARA120895665
AMER121593754
ASTE118509523
AFUN125772032
AMOU128305499
AALI118465043
AAG5565246
AALB109410517
CQUCpipJ_CPIJ007345
CPII120430753
CNS116345940
BCOO119080661
AME413372
ACER108004089
ALAB122714169
ADR102678387
AFLR100863333
BIM100743936
BBIF117208172
BVK117235398
BVAN117154250
BTER100648506
BAFF126916388
BPYO122565625
BPAS132905378
FVI122535197
CCAL108629149
OBB114879469
OLG117610793
MGEN117218009
NMEA116432027
CGIG122398534
SOC105197574
MPHA105838501
AEC105149802
ACEP105627138
PBAR105424147
VEM105559493
HST105181045
DQU106749864
CFO105259420
FEX115245214
LHU105677426
PGC109859877
OBO105286430
PCF106785427
PFUC122514263
VPS122634919
VCRB124430514
VVE124954153
NVI100122109
CSOL105368803
TPRE106656707
LHT122508094
LBD127280028
MDL103570096
CGLO123272834
FAS105270599
DAM107043748
AGIF122853354
CINS118074872
VCAN122411181
CCIN107270167
DSM124416509
NPT124224641
NFB124182271
NLO107216749
NVG124304630
AROA105689110
TCA658584
DPA109543624 125503707
SOY115886449
AGRG126745911
ATD109601527
CSET123312571
AGB108917077
LDC111508893
APLN108732952
PPYR116171129
OTU111413251
MSEX115452078
DPLKGM_210060
BANY112047329
MJU123866946
NIQ126768611
VCD124530588
MCIX123654185
PPOT106100510
PXU106125288
PRAP110993503
PBX123714623
PNAP125060109
ZCE119831402
CCRC123692791
LSIN126973096
HZE124630844
SLIU111349578
OFU114358173
PGW126367002
CFEL113378636
CCRN123290403
API100158883
DNX107164646
AGS114126871
RMD113555018
ACOO126832971
DVT126906074
BTAB109029618
DCI103524615
CLEC106667559
HHAL106690746
NLU111052344
HVI124358254
MQU128983935
FOC113206005
TPAL117639366
ZNE110836732
CSEC111865708
SGRE126284988
IEL124160182
DPXDAPPUDRAFT_110162
DMK116920522
DPZ124316122
PVM113799962
PJA122255183
PCHN125045218
PMOO119584663
HAME121879794
PCLA123755771
CQD128704206
PTRU123520672
ESN126998347
HAZT108678918
EAF111704323
LSM121128450
TCF131887265
PPOI119102368 119102488
ISC120849612
DSV119461673
RSAN119395866
RMP119174150
VDE111247835
VJA111272506
DFR124499735
UDV129224565 129232157
SDM118187282 118187991
LPOL106459606
CELCELE_W07E11.1(W07E11.1)
CBRCBG_01975
CRQGCK72_023520
PVUL126810534
BGT106056462
GAE121371892
HRF124116337
HRJ124282667
CRG105337796
CVN111100398 111100399
CANU128186176
OED125673905
MYI110451591
PMAX117327627
MMER123552518
RPHI132756035
DPOL127852221
OBI106883777
OSN115223129
XEN124443157
ATHAT5G53460(GLT1)
ALY9300320
CRB17876423
CSAT104725863 104728554 104761363
EUSEUTSA_v10012414mg
BRP103857079
BNA106387482 111213076
BOE106332590
RSZ108845736
THJ104811925
CPAP110823143
CIT102620225
PVY116133280
MINC123198124 123206665 123226207
TCC18605743
GRA105765457
GHI107929529 107947250
GAB108479092
HSYR120117517 120184088 120206192
DZI111280486 111289287 111309227
EGR104437859
GMX100815931
GSJ114410308
PVUPHAVU_001G076400g
VRA106764633
VAR108331410
VUN114194130
VUM124822217
CCAJ109814577
APRC113850812
MTR25482265
TPRA123902867
CAM101509615
PSAT127091893
VVO131596096
ADU107495014
AIP107605257
AHF112697424 112705922 112755343 112765389
LANG109326556
QSAO6P43_015015 O6P43_019921
FVE101309397
RCN112183464
PPER18785174
PMUM103333633
PAVI110767133
PDUL117619118
MDM103439880 103443818
MSYL126624044 126629149
PXB103941488 103943433 103967236
ZJU107414598
MNT21390250
CSAV115715577
CSV101213224
CMO103485701
BHJ120081937
MCHA111011404
CMAX111482791
CMOS111430634
CPEP111810135
RCU8274353
JCU105648339
HBR110665757 110666168
MESC110617349 110630652
POP18103637 7453835
PEU105109026 105110510
PALZ118033501 118057296
JRE109004582 109013214
CILL122311011 122312965
CAVE132162263 132165333
QSU112017959
QLO115959755
TWL119984320 120003889
VVI100246868
VRI117933639
SLY101254281
SPEN107013700
SOT102580516
SSTN125858190
SDUL129894061
CANN107855963
LBB132632063
NSY104244568
NAU109213942
INI109183410
ITR116012569
SIND105160371
OEU111405628
EGT105971643
SSPL121747965 121752173 121779747 121782410
SMIL131014672
APAN127256298 127259584
HAN110878172 110912724
ECAD122586618
LSV111918005
CCAV112508668 112515985
DCR108214500 108226948
CSIN114285508 114310758
RVL131301738 131319786 131319792
AEW130753473 130767247
BVG104888263
SOE110783090
CQI110696098 110728845
ATRI130806671
MOF131145391
NNU104600364 104604004
MING122062882 122081042
TSS122640469 122666202
PSOM113299164 113358466
OSA4324398 4339561
DOSAOs05t0555600-01(Os05g0555600)
OBR102713634 102721892
OGL127761687 127773744
BDI100832857 100844360
ATS109760356
TDC119268802 119279609
TAES123061864 123070558 123078967
LPER127343353
LRD124660979
SBI8068026
ZMA103636185 103651348
SITA101785947
SVS117857834
PVIR120664696 120675270 120697894 120707627
PHAI112894413
PDA103708325 103713334
EGU105039187 105041491
MUS103980032 103992734 103996064
ZOF122020245 122025187 122026291 122032959 122033388
DCT110110468
PEQ110020245
AOF109840747
MSIN131241230 131245159
NCOL116266917
ATR18442390
SMOSELMODRAFT_446658
PPP112283025
CRECHLRE_13g592200v5
VCNVOLCADRAFT_108038
APROF751_6615
MISMICPUN_105473(GLT)
MPPMICPUCDRAFT_57115(GLT)
SCEYDL171C(GLT1)
SEUBDI49_0907
SPAOSPAR_D00710
AGOAGOS_ADR290W
ERCEcym_4713
KLAKLLA0_E19625g
KMXKLMA_50304(GLT1)
LTHKLTH0B04708g
VPOKpol_530p21
ZROZYRO0B02596g
CGRCAGL0L01089g
NCSNCAS_0A14190(NCAS0A14190)
NDINDAI_0A01860(NDAI0A01860)
TPFTPHA_0F03070(TPHA0F03070)
TGBHG536_0B05360
TDLTDEL_0C01870(TDEL0C01870)
KNGKNAG_0C03720(KNAG0C03720)
ZMKHG535_0B04610
DHADEHA2G15642g
PICPICST_87428(GLT1)
SPAASPAPADRAFT_141734(GLT1)
LELPVL30_000542(GLT1)
CALCAALFM_C106550WA(GLT1)
CTPCTRG_04234
COTCORT_0A06160
CDUCD36_06130
CTENCANTEDRAFT_101139
YLIYALI0B19998g
CLUCLUG_03565
CLUSA9F13_01g06028
CAURCJI96_0003482
PKZC5L36_0E05370
BNNFOA43_002177(GLT1)
BBRXBRETT_003814
OPAHPODL_00613
SLUDSCDLUD_000217
NCRNCU01744(en(am)-2)
NTENEUTE1DRAFT65142(NEUTE1DRAFT_65142)
SMPSMAC_02431
PANPODANSg6535
PBELQC761_0055180(GLT1_2)
PPSDQC762_0055380(GLT1)
PPSPQC763_0054760(GLT1)
PPSAQC764_0054500(GLT1)
TTTTHITE_2124366
MTMMYCTH_2312662
CTHRCTHT_0008270
MGRMGG_07187
PPEIPpBr36_01824
PGRIPgNI_07601
TMNUCRPA7_4478
SSCKSPSK_08269
FGRFGSG_01433
FPUFPSE_08520
FPOAFPOAC1_001542(GLT1)
FVNFVRRES_01748
FVRFVEG_09511
FOXFOXG_11281
NHENECHADRAFT_57063
FFCNCS54_00040100
FKRNCS57_00038200
FMUJ7337_000450(GLT1)
TRETRIREDRAFT_122287(glt1)
TRRM419DRAFT_24904
MAWMAC_00032
MAJMAA_01819
PCHMVFPPC_01998
CMTCCM_03495
AMUSLMH87_010616
PLJVFPFJ_07201
PTKZJDV02_006427(GLT1)
CFJCFIO01_07667
CLUPCLUP02_00774
CHIGCH63R_12724
SAPOSAPIO_CDS0981
ELAUCREL1_4299
PFYPFICI_11366
SSLSS1G_07849
BFUBCIN_15g02460(Bcglt1)
MBEMBM_04374
PSCOLY89DRAFT_691010
GLZGLAREA_03052
ANIANIA_05134
AFMAFUA_1G07380
ACTACLA_027210
NFINFIA_017350
AORAO090012000988
ANGAn07g09920
AFVAFLA_002716
ALUCAKAW2_11294S(GLT1)
APUUAPUU_41225A(GLT1)
PCSN7525_005197
PDPPDIP_26070
POUPOX_e06407
TMFEYB26_006835
TRGTRUGW13939_11475
CIMCIMG_02486
CPWCPC735_041070
UREUREG_03225
PBLPAAG_12483(PAAG_07998)
PBNPADG_02101
ABEARB_04215
TVETRV_01094
BGHBDBG_06065
PTEPTT_08692
BZECOCCADRAFT_4567
BSCCOCSADRAFT_185254
BORCOCMIDRAFT_10233
AALTCC77DRAFT_261749
ARABEKO05_0008651
ZTRMYCGRDRAFT_110982
PFJMYCFIDRAFT_52899
FFUCLAFUR5_03176
CBETCB0940_03694
BCOMBAUCODRAFT_475239
NPAUCRNP2_1000
TMLGSTUM_00002450001
SPOSPAPB1E7.07(glt1)
SOMSOMG_00784(glt1)
CNECNJ02910
CNBCNBJ0620
CNGCNAG_04862
CGICGB_I4060C
CDEUCNBG_5689
TMSTREMEDRAFT_42578
TASAA1Q1_06977
CCACCcaHIS019_0602820(GLT1)
TVSTRAVEDRAFT_27775
DSQDICSQDRAFT_177406
PCOPHACADRAFT_127541
SHSSTEHIDRAFT_74778
HIRHETIRDRAFT_433732
PSQPUNSTDRAFT_144302
ADLAURDEDRAFT_114408
FMEFOMMEDRAFT_166121
GTRGLOTRDRAFT_137109
RSXRhiXN_02756
LBCLACBIDRAFT_183838
CCICC1G_13933
ABPAGABI1DRAFT104661(AGABI1DRAFT_104661)
ABVAGABI2DRAFT176670(AGABI2DRAFT_176670)
PCUBJR316_0003626
MRRMoror_14828
MOREE1B28_002588(GLT1)
SCMSCHCO_02607326(SCHCODRAFT_02607326)
CPUTCONPUDRAFT_80026
SLASERLADRAFT_357441(NADH-GOGAT)
UMAUMAG_03850
PFPPFL1_06431
SGRAEX895_001280
MGLMGL_2017
MRTMRET_1549
MSYMMSY001_1099
PGRPGTG_15142
PTRCPtA15_6A702
PSTRPst134EA_002810
MLRMELLADRAFT_48761
MBRMONBRDRAFT_15256
PFAPF3D7_1435300
PFDPFDG_02810
PFHPFHG_00264
PREIPRSY57_1434600
PGABPGSY75_1435300
PYOPY17X_1011100
PCBPCHAS_1010400
PBEPBANKA_1009500
PVVPVVCY_0801000
PKNPKNH_0421900
PVXPVX_084770
PCYPCYB_132360
PMALPMUG01_13025000
PRELPRELSG_1315800
PTIPHATRDRAFT_51214(GltX)
TPSTHAPSDRAFT_29861
 » show all
Reference
1  [PMID:4362465]
  Authors
Roon RJ, Even HL, Larimore F
  Title
Glutamate synthase: properties of the reduced nicotinamide adenine dinucleotide-dependent enzyme from Saccharomyces cerevisiae.
  Journal
J Bacteriol 118:89-95 (1974)
DOI:10.1128/JB.118.1.89-95.1974
Reference
2  [PMID:21790]
  Authors
Boland MJ, Benny AG.
  Title
Enzymes of nitrogen metabolism in legume nodules. Purification and properties of NADH-dependent glutamate synthase from lupin nodules.
  Journal
Eur J Biochem 79:355-62 (1977)
DOI:10.1111/j.1432-1033.1977.tb11816.x
Reference
3  [PMID:7047525]
  Authors
Masters DS Jr, Meister A
  Title
Inhibition of homocysteine sulfonamide of glutamate synthase purified from Saccharomyces cerevisiae.
  Journal
J Biol Chem 257:8711-5 (1982)
Reference
4  [PMID:16666762]
  Authors
Anderson MP, Vance CP, Heichel GH, Miller SS
  Title
Purification and Characterization of NADH-Glutamate Synthase from Alfalfa Root Nodules.
  Journal
Plant Physiol 90:351-8 (1989)
DOI:10.1104/pp.90.1.351
Reference
5  [PMID:18182018]
  Authors
Blanco L, Reddy PM, Silvente S, Bucciarelli B, Khandual S, Alvarado-Affantranger X, Sanchez F, Miller S, Vance C, Lara-Flores M
  Title
Molecular cloning, characterization and regulation of two different NADH-glutamate synthase cDNAs in bean nodules.
  Journal
Plant Cell Environ 31:454-72 (2008)
DOI:10.1111/j.1365-3040.2008.01774.x
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.14
IUBMB Enzyme Nomenclature: 1.4.1.14
ExPASy - ENZYME nomenclature database: 1.4.1.14
BRENDA, the Enzyme Database: 1.4.1.14
CAS: 65589-88-0
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