KEGG ENZYME: 1.4.3.20

ENZYME: 1.4.3.20

Entry

EC 1.4.3.20                 Enzyme

Name

L-lysine 6-oxidase;
L-lysine-epsilon-oxidase;
Lod;
LodA;
marinocine

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor

Sysname

L-lysine:oxygen 6-oxidoreductase (deaminating)

Reaction(IUBMB)

L-lysine + O2 + H2O = (S)-2-amino-6-oxohexanoate + H2O2 + NH3 [RN:R07598]

Reaction(KEGG)

R07598

Substrate

L-lysine [CPD:C00047];
O2 [CPD:C00007];
H2O [CPD:C00001]

Product

(S)-2-amino-6-oxohexanoate [CPD:C04076];
H2O2 [CPD:C00027];
NH3 [CPD:C00014]

Comment

Differs from EC 1.4.3.13, protein-lysine 6-oxidase, by using free L-lysine rather than the protein-bound form. N2-Acetyl-L-lysine is also a substrate, but N6-acetyl-L-lysine, which has an acetyl group at position 6, is not a substrate. Also acts on L-ornithine, D-lysine and 4-hydroxy-L-lysine, but more slowly. The amines cadaverine and putrescine are not substrates [2].

History

EC 1.4.3.20 created 2006, modified 2011

Orthology

K17831

L-lysine 6-oxidase

Genes

PVD:	CFBP1590__2366(lodA)

PXN:	HU772_020795(lodA)

PFLI:

CTT31_18845

PMAZ:

R5H13_24655(lodA)

NTG:	NSCAC_0191

MMW:	Mmwyl1_3721

MME:	Marme_2662

MARD:

IBG28_03800

CARI:

FNU76_09445

JAH:	JAB4_031930(lodA)

MANC:

IV454_11660(lodA)

DZO:	SR858_13615(lodA)

NIZ:	NNRS527_02070

COY:	HF329_27665(lodA)

SSIY:

JVX97_19055(lodA)

MSAB:

SNE25_26145(lodA)

CGAM:

PFY09_01290(lodA)

» show all

Reference

1 [PMID:16547036]

Authors

Lucas-Elio P, Gomez D, Solano F, Sanchez-Amat A

Title

The antimicrobial activity of marinocine, synthesized by Marinomonas mediterranea, is due to hydrogen peroxide generated by its lysine oxidase activity.

Journal

J Bacteriol 188:2493-501 (2006)
DOI:10.1128/JB.188.7.2493-2501.2006

Sequence

[mme:Marme_2662]

Reference

2 [PMID:17030025]

Authors

Gomez D, Lucas-Elio P, Sanchez-Amat A, Solano F

Title

A novel type of lysine oxidase: L-lysine-epsilon-oxidase.

Journal

Biochim Biophys Acta 1764:1577-85 (2006)
DOI:10.1016/j.bbapap.2006.08.014