Entry
Name
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(-)-ephedrine:NAD+ 2-oxidoreductase
Reaction(IUBMB)
(-)-ephedrine + NAD+ = (R)-2-methylimino-1-phenylpropan-1-ol + NADH + H+ [RN:
R03614 ]
Reaction(KEGG)
Substrate
Product
Comment
The product immediately hydrolyses to methylamine and 1-hydroxy-1-phenylpropan-2-one. Acts on a number of related compounds including (-)-sympatol, (+)-pseudoephedrine and (+)-norephedrine.
History
EC 1.5.1.18 created 1984
Pathway
ec00996 Biosynthesis of various alkaloids
ec01110 Biosynthesis of secondary metabolites
Reference
Authors
Klamann E, Lingens F.
Title
Degradation of (-)-ephedrine by Pseudomonas putida. Detection of (-)-ephedrine: NAD+-oxidoreductase from Arthrobacter globiformis.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.18
ExPASy - ENZYME nomenclature database: 1.5.1.18
LinkDB
All DBs