| Entry |
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| Name |
saccharopine dehydrogenase (NAD+, L-lysine-forming);
lysine-2-oxoglutarate reductase;
dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming);
epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming);
N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming);
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
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| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
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| Reaction(IUBMB) |
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+ [RN: R00715]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| History |
EC 1.5.1.7 created 1972
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K00290 | saccharopine dehydrogenase (NAD+, L-lysine forming) |
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| Genes |
| ATEN: | 116297853 116298760 116300891 116300965 |
| SPIS: | 111333439 111333523 111335282 111337694 |
| NCS: | NCAS_0A08650(NCAS0A08650) |
| NDI: | NDAI_0G05090(NDAI0G05090) |
| TPF: | TPHA_0N01860(TPHA0N01860) |
| TBL: | TBLA_0C01000(TBLA0C01000) |
| TDL: | TDEL_0B07590(TDEL0B07590) |
| KAF: | KAFR_0A00160(KAFR0A00160) |
| KNG: | KNAG_0H00170(KNAG0H00170) KNAG_0M02400(KNAG0M02400) |
| SPAA: | SPAPADRAFT_147229(LYS1) |
| LEL: | PVL30_004380(LYS1_2) |
| CAL: | CAALFM_C405320WA(LYS1) |
| CTEN: | CANTEDRAFT_113510 CANTEDRAFT_115850 |
| NTE: | NEUTE1DRAFT91293(NEUTE1DRAFT_91293) |
| FVR: | FVEG_11605 FVEG_16154 |
| FMU: | J7337_010011 J7337_010372 |
| BFU: | BCIN_05g04270(Bclys1) |
| PSCO: | LY89DRAFT_604497 LY89DRAFT_651629 |
| ALUC: | AKAW2_10619A(LYS1_1) |
| ACHE: | ACHE_21163A(LYS1_2) |
| APUU: | APUU_30693A(LYS1_2) |
| CCAC: | CcaHIS019_0608570(LYS1) |
| ABP: | AGABI1DRAFT96692(AGABI1DRAFT_96692) |
| ABV: | AGABI2DRAFT133180(AGABI2DRAFT_133180) |
| SCM: | SCHCO_02612998(SCHCODRAFT_02612998) |
| CATE: | C2869_06635 C2869_13100 |
| SALH: | HMF8227_02643(lys1) |
| GAI: | IMCC3135_13135 IMCC3135_26915 |
| OAI: | OLEAN_C07010 OLEAN_C24260 |
| SIL: | SPO0601 SPO3307(lkr) |
| RUA: | D1823_00500 D1823_16465 |
| RUT: | FIU92_12470 FIU92_14995(ald2) |
| RCON: | K3740_04350 K3740_16350 |
| RMM: | ROSMUCSMR3_00818(ald) |
| RID: | RIdsm_04346 RIdsm_04909 |
| MALU: | KU6B_07830 KU6B_07840 |
| HAT: | RC74_05215 RC74_05700 |
| LVS: | LOKVESSMR4R_03787(ald) |
| SEDI: | EBB79_11800 EBB79_19195 |
| PPSO: | QPJ95_09065 QPJ95_16250 |
| CACT: | HZ995_08090 HZ995_09890 |
| ACRO: | K3J57_00195 K3J57_12315 |
| PBAE: | P8S53_01660 P8S53_15720 |
| SBIN: | SBA_ch1_25000(lys1) |
| HPO: | HMPREF4655_20104(LYS1) |
| HPX: | HMPREF0462_1493(LYS1) |
| ABL: | A7H1H_1662 A7H1H_2109 |
| ASK: | EI285_07265 EI285_09645 |
| ACIB: | ACBT_0802 ACBT_2321 |
| ACRE: | ACRYA_1430 ACRYA_2009 |
| ALAN: | ALANTH_1724 ALANTH_2212 |
| AFC: | AFAEC_0612 AFAEC_2302 |
| APOC: | APORC_1413 APORC_2061 |
| NAM: | NAMH_0224(lys) NAMH_0225(lys) |
| NAP: | C3L23_01130 C3L23_01135 |
| CMED: | FE773_03055 FE773_03065 |
| CPAF: | C6V80_01380 C6V80_01400 |
| PPOR: | JCM14722_30440(lys1) |
| DOV: | DSCO28_05080 DSCO28_32810 |
| DALK: | DSCA_16390 DSCA_50130 |
| HAX: | BALOs_2120 BALOs_2686 |
| BFM: | BP422_17855 BP422_27170 |
| PPM: | PPSC2_06880(lyS1) PPSC2_08685(lyS2) |
| PPO: | PPM_1306(lyS1) PPM_1652(lyS2) |
| PPOL: | X809_07500 X809_08940 |
| PPQ: | PPSQR21_014060(lYS9) PPSQR21_017260 |
| PPOY: | RE92_03620 RE92_05005 |
| PTA: | HPL003_15220 HPL003_16630 |
| PGM: | PGRAT_01260 PGRAT_11400 |
| PAEA: | R70723_01050 R70723_11040 |
| PAEE: | R70331_01005 R70331_10800 |
| PPEO: | ABE82_06995 ABE82_08775 |
| PXL: | BS614_16935 BS614_18405 |
| PDH: | B9T62_06580 B9T62_11715 |
| PKB: | B4V02_16675 B4V02_18025 |
| PAIH: | ASL14_02730 ASL14_04415 |
| PBAC: | HUB98_00360 HUB98_01260 |
| SNC: | HMPREF0837_11566(LYS1) |
| CLO: | HMPREF0868_0009(LYS1) |
| VGU: | HYG85_03650 HYG85_16715 |
| MANA: | MAMMFC1_02826(argC_2) |
| MBAI: | MB901379_03170(lysDH) |
| SDV: | BN159_1824 BN159_8305 |
| SCI: | B446_04245 B446_30345 |
| SCX: | AS200_10130 AS200_41000 |
| STSI: | A4E84_02265 A4E84_34035 |
| SGM: | GCM10017557_34240(sdh) |
| SLS: | SLINC_0453 SLINC_7047 |
| SLX: | SLAV_08715 SLAV_37485 SLAV_39975 |
| SNZ: | DC008_29075 DC008_31930 |
| SGE: | DWG14_01558 DWG14_07934 |
| SCYA: | EJ357_39670 EJ357_44750 |
| SHAW: | CEB94_02745 CEB94_34915 |
| SFY: | GFH48_08890 GFH48_35515 |
| SAQU: | EJC51_05625 EJC51_38675 |
| SPHV: | F9278_24660 F9278_40085 |
| SCHA: | CP983_07345 CP983_41060 |
| SCOE: | CP976_36405 CP976_40370 |
| STUI: | GCM10017668_59820(sdh) GCM10017668_66430 |
| SROI: | IAG44_02525 IAG44_06805 |
| SLF: | JEQ17_04505 JEQ17_09520 |
| SCIR: | STRCI_000385 STRCI_006728 |
| SJN: | RI060_06475 RI060_41025 |
| SKG: | KJK29_04865 KJK29_37845 |
| SCOA: | QU709_05970 QU709_43395 |
| FSB: | GCM10025867_05910(lys1) |
| NSN: | EXE58_03105 EXE58_05735 |
| NPI: | G7071_01015 G7071_10640 |
| NPS: | KRR39_04630 KRR39_09915 |
| AWN: | NQV15_05905 NQV15_11540 |
| ACTR: | Asp14428_02490(lys1) |
| SYY: | SYNGTS_2301(slr0049) |
| SYT: | SYNGTI_2300(slr0049) |
| SYS: | SYNPCCN_2299(slr0049) |
| SYQ: | SYNPCCP_2299(slr0049) |
| PAH: | Poras_0536 Poras_0960 |
| PET: | PEIBARAKI_4456 PEIBARAKI_5777 |
| PMZ: | HMPREF0659_A5557(LYS1) |
| PDN: | HMPREF9137_1758(LYS1) |
| DORI: | FH5T_01740 FH5T_04380 |
| DRC: | G0Q07_07000 G0Q07_17705 |
| MCOS: | GM418_02580 GM418_04190 |
| HHY: | Halhy_6334 Halhy_R0059 |
| PSEZ: | HME7025_01355(lys1) |
| ALS: | DJ013_11510 DJ013_15555 |
| FLI: | Fleli_1145 Fleli_2967 |
| FPF: | DCC35_02310 DCC35_11210 |
| FBT: | D770_11945 D770_15445 |
| SPON: | HME9304_00590(aasS) |
| GTL: | EP073_04290 EP073_13645 |
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| Reference |
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| Authors |
Fujioka M, Nakatani Y. |
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| Title |
Saccharopine dehydrogenase. Interaction with substrate analogues. |
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| Journal |
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| Reference |
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| Authors |
Saunders PP, Broquist HP |
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| Title |
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. IV. Saccharopine dehydrogenase. |
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| Journal |
J Biol Chem 241:3435-40 (1966) |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.5.1.7 |
| ExPASy - ENZYME nomenclature database: | 1.5.1.7 |
| BRENDA, the Enzyme Database: | 1.5.1.7 |
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| LinkDB |
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