KEGG ENZYME: 1.7.1.12

ENZYME: 1.7.1.12

Entry

EC 1.7.1.12                 Enzyme

Name

N-hydroxy-2-acetamidofluorene reductase;
N-hydroxy-2-acetylaminofluorene reductase;
NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase

Class

Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor

Sysname

2-acetamidofluorene:NAD(P)+ oxidoreductase

Reaction(IUBMB)

2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+ [RN:R04046 R04047]

Reaction(KEGG)

Substrate

2-acetamidofluorene [CPD:C02778];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Product

N-hydroxy-2-acetamidofluorene [CPD:C03954];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Also acts, more slowly, on N-hydroxy-4-acetamidobiphenyl.

History

EC 1.7.1.12 created 1989 as EC 1.6.6.13, transferred 2002 to EC 1.7.1.12

Reference

1 [PMID:5780838]

Authors

Gutmann HR, Erickson RR.

Title

The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver in vitro. An inducible enzymatic reaction.

Journal

J Biol Chem 244:1729-40 (1969)

Reference

2 [PMID:4074379]

Authors

Kitamura S, Tatsumi K.

Title

Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol.

Journal

Biochem Biophys Res Commun 133:67-74 (1985)
DOI:10.1016/0006-291X(85)91842-X

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

CAS:	99890-08-1

LinkDB

DBGET integrated database retrieval system