Entry
Name
preQ1 synthase;
YkvM;
QueF;
preQ0 reductase;
preQ0 oxidoreductase;
7-cyano-7-deazaguanine reductase;
queuine synthase (incorrect as queuine is not the product);
queuine:NADP+ oxidoreductase (incorrect as queuine is not the product)
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase
Reaction(IUBMB)
7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH + 2 H+ [RN:
R07605 ]
Reaction(KEGG)
Substrate
7-aminomethyl-7-carbaguanine [CPD:
C16675 ];
NADP+ [CPD:
C00006 ]
Product
Comment
The reaction occurs in the reverse direction. This enzyme catalyses one of the early steps in the synthesis of queuosine (Q-tRNA), and is followed by the action of EC
2.4.2.29 , tRNA-guanosine34 transglycosylase. Queuosine is found in the wobble position of tRNAGUN in Eukarya and Bacteria [2] and is thought to be involved in translational modulation. The enzyme is not a GTP cyclohydrolase, as was thought previously based on sequence-homology studies.
History
EC 1.7.1.13 created 2006
Pathway
Orthology
K06879 7-cyano-7-deazaguanine reductase
K09457 7-cyano-7-deazaguanine reductase
Genes
ECOO : ECRM13514_3656(queF)
ECOH : ECRM13516_3521(queF)
ELR : ECO55CA74_16435(queF)
ECW : EcE24377A_3099(queF)
ECOA : APECO78_17590(queF)
EDJ : ECDH1ME8569_2704(queF)
ECOI : ECOPMV1_03051(queF)
SEM : STMDT12_C30200(queF)
SETC : CFSAN001921_02230(queF)
SEEN : SE451236_20935(queF)
SENH : CFSAN002069_17380(queF)
SEEH : SEEH1578_00895(queF)
SENJ : CFSAN001992_18725(queF)
SEEC : CFSAN002050_21195(queF)
SEEB : SEEB0189_005285(queF)
SENC : SEET0819_21705(queF)
REE : electrica_00921(queF)
HDE : HDEF_1045(queF_1) HDEF_1522(queF_2)
CLAP : NCTC11466_00711(queF)
KIE : NCTC12125_04907(queF)
BAGE : BADSM9389_08910(queF)
AHN : NCTC12129_03984(queF)
METY : MRY16398_10160(queF)
PTF : PROFFT_A_05880(queF)
PSHI : SAMEA2665130_2404(queF)
YPG : YpAngola_A3157(queF)
YPI : YpsIP31758_1004(queF)
SMAR : SM39_3402(queF) SM39_3661
SMAC : SMDB11_3191(queF) SMDB11_3466
SMW : SMWW4_v1c39210(queF) SMWW4_v1c41600
SRR : SerAS9_3989 SerAS9_4330
SRY : M621_20225(queF) M621_22010(queF)
SPLY : Q5A_020050(queF_1) Q5A_021975(queF_2)
SRS : SerAS12_3990 SerAS12_4331
SRA : SerAS13_3990 SerAS13_4331
SERF : L085_07245(queF) L085_09085(queF)
SERS : SERRSCBI_18985(queF) SERRSCBI_20235(queF)
SQU : E4343_19770(queF) E4343_21430(queF)
SFJ : SAMEA4384070_3918(queF_1) SAMEA4384070_4194(queF_2)
SOF : NCTC11214_02445(queF_1) NCTC11214_02838(queF_2)
SSUR : ATE40_016295 ATE40_017520
SURI : J0X03_03100(queF) J0X03_04390(queF)
SENP : KHA73_19075(queF) KHA73_20445(queF)
SNEM : NLX84_19740(queF) NLX84_21490(queF)
SNEV : OI978_10050(queF) OI978_12390(queF)
PAQU : DMB82_0015785(queF)
DIC : Dpoa569_003115(queF)
EHD : ERCIPSTX3056_360(queF)
ETO : RIN69_00615(queF) RIN69_17915(queF)
BAPF : BUMPF009_CDS00298(quef)
BAPG : BUMPG002_CDS00299(quef)
BAPU : BUMPUSDA_CDS00298(quef)
BAPW : BUMPW106_CDS00298(quef)
PAO : Pat9b_3109 Pat9b_3310
TPTY : NCTC11468_00878(queF)
PTT : VY86_04530(queF) VY86_12455(queF)
PHEI : NCTC12003_03068(queF)
PRJ : NCTC6933_03168(queF)
ANS : ArsFIN_06090(queF_1) ArsFIN_50850(queF_2)
LRI : NCTC12151_00697(queF)
HIC : NTHIC486_01373(queF)
HPIT : NCTC13334_01565(queF)
HHZ : NCTC10839_01382(queF)
HAEG : NCTC8502_01718(queF)
PDAG : 4362423_00877(queF)
ADP : NCTC12871_00116(queF)
ALIG : NCTC10568_00503(queF)
ASEG : NCTC10977_01508(queF)
AVT : NCTC3438_01431(queF)
RPNE : NCTC8284_02132(queF_2)
PAET : NCTC13378_01020(queF)
XFU : XFF4834R_chr37330(queF)
XPH : XppCFBP6546_15185(queF)
XHD : LMG31886_39800(queF)
LLZ : LYB30171_00086(queF)
VAU : VANGNB10_cI0778c(queF)
VCY : IX92_03345(queF) IX92_18135
VCT : JV59_20970 JV59_35375(queF)
VGA : BSQ33_08450 BSQ33_13505
VSR : Vspart_00940(queF_1) Vspart_03323(queF_2)
VPL : SA104470976_01865(queF)
VNP : KW548_14530(queF) KW548_18760(queF)
VRU : RND59_01490(queF) RND59_06640(queF)
PMAI : CF386_01445(queF) CF386_09590
PAEB : NCGM1900_3608(queF)
PVD : CFBP1590__1969(queF)
PPRC : PFLCHA0_c20220(queF)
PMUD : NCTC8068_03623(queF)
PFW : PF1751_v1c15630(queF)
PFF : PFLUOLIPICF700505(queF)
PPUU : PputUW4_03498(cinQ)
PTRT : HU722_0008880(queF)
PTW : TUM18999_25660(queF)
PTAE : NCTC10697_01352(queF)
MSHE : MAALD49_22380(queF)
PSYC : DABAL43B_0538(queF)
MCAT : MC25239_01383(queF)
MCUN : NCTC10297_00737(queF)
SCAA : TUM17387_27720(queF)
PLZ : S4054249_17270(queF)
SALH : HMF8227_02169(queF)
CBS : COXBURSA331_A0243(queF)
LPO : LPO_0693(queF) LPO_p0031
LLG : 44548918_00658(queF_1) 44548918_01715(queF_2)
LJR : NCTC11533_01889(queF)
LCJ : NCTC11976_01123(queF)
LWA : SAMEA4504053_1446(queF)
LSS : NCTC12082_02325(queF)
LADL : NCTC12735_01397(queF)
LANT : TUM19329_08250(queF)
MISZ : MishRS11D_02110(queF)
TIB : THMIRHAM_22360(queF)
TSE : THMIRHAS_24860(queF)
TZO : THMIRHAT_23230(queF)
TFRI : Thiofri_00903(queF)
TNI : TVNIR_1418(queF_[H])
GAI : IMCC3135_21425(queF)
THIC : TspCOW1_08960(queF)
ALCA : ASALC70_03894(queF)
PLEI : Q9312_08660 Q9312_16765(queF)
AEL : NCTC12917_03231(queF)
CHJ : NCTC10426_00836(queF)
CDIZ : CEDIAZO_01182(queF)
NMM : NMBM01240149_1766(queF)
NMS : NMBM01240355_0328(queF)
NMQ : NMBM04240196_0325(queF)
NMZ : NMBNZ0533_1927(queF)
NWE : SAMEA3174300_1468(queF)
NZO : SAMEA4504057_2263(queF)
NCI : NCTC10296_00220(queF)
NCZ : NCTC10294_00030(queF)
NANI : NCTC12227_00305(queF)
ECOR : SAMEA4412678_0230(queF)
REH : H16_A0426(h16_A0426)
BMV : BMASAVP1_A2767(queF)
BML : BMA10229_A2311(queF)
BPM : BURPS1710b_0839(queF)
BPL : BURPS1106A_0676(queF)
BSAV : WS86_15835 WS86_26600
BUB : BW23_2157(queF) BW23_964(queF)
BSTG : WT74_03810 WT74_14500
BUE : BRPE67_ACDS02800(queF)
PBON : QS306_03205(queF) QS306_04835(queF)
PPUL : RO07_12520 RO07_19650
PSPU : NA29_08595 NA29_25525
PNR : AT302_12595 AT302_22535
PAND : DRB87_03850 DRB87_09985
PFIB : PI93_003890(queF) PI93_016775
PCOM : NTU39_04630(queF) NTU39_11965
PLG : NCTC10937_01969(queF)
LMIR : NCTC12852_00431(queF)
BTRM : SAMEA390648704150(queF)
AXX : ERS451415_04627(queF)
LIM : L103DPR2_02454(queF)
LIH : L63ED372_02076(queF)
URU : DSM104443_01014(queF)
UPL : DSM104440_00925(queF)
FPHO : SHINM1_011430(queF)
RTT : RTTH1527_00280(queF)
RTB : RTB9991CWPP_00280(queF)
PTC : phytr_5200 phytr_9910
RBS : RHODOSMS8_00913(queF)
SMEL : SM2011_c02723(queF)
SFD : USDA257_c47140(queF)
SAME : SAMCFNEI73_Ch2681(queF)
ALF : CFBP5473_04095(queF)
AVV : RvVAT039_06350(queF)
AVF : RvVAR031_26300(queF)
ASAL : CFBP5507_10100(queF)
RPUS : CFBP5875_09775(queF)
ALEG : CFBP4996_09735(queF)
REL : REMIM1_CH03116(queF)
REP : IE4803_CH03290(queF)
REI : IE4771_CH03326(queF)
RTR : RTCIAT899_CH12925(queF)
RGA : RGR602_CH02703(queF)
RPHA : AMC79_CH03229(queF)
RLW : RlegWSM1455_15435(queF)
RBW : RLCC275e_15910(queF)
NEN : NCHU2750_23800(queF)
BIO : BR141012304_11507(queF)
BSEP : HAP48_0040105(queF)
BCAN : BcanWSM471_21440(queF)
VGO : GJW-30_1_02858(queF)
MMES : MMSR116_26150(queF)
MTUN : MTUNDRAET4_1101(queF)
FIL : BN1229_v1_2820(queF)
FIY : BN1229_v1_3093(queF)
DSAL : K1X15_07320(queF) K1X15_13560(queF) K1X15_13770(queF)
BVY : NCTC9239_02022(queF)
TSV : DSM104635_01458(queF)
PHP : PhaeoP97_02792(queF)
PPIC : PhaeoP14_00485(queF)
SINL : DSM14862_02084(queF)
RMM : ROSMUCSMR3_03730(queF)
LVS : LOKVESSMR4R_00076(queF)
SBIN : SBA_ch1_11160(queF)
SFLA : SPHFLASMR4Y_01837(queF)
ALI : AZOLI_2152(queF) AZOLI_p20327
ABF : AMK58_05255 AMK58_19515
ATI : AL072_08425 AL072_20505
AZZ : DEW08_04800 DEW08_22945
HPO : HMPREF4655_20005(queF)
HPX : HMPREF0462_1391(queF)
HAD : CDV25_06340(queF) CDV25_07430
HSH : NHP194022_14530(queF)
HPUL : NCTC13154_00020(queF)
SSEI : FJR45_04835 FJR45_04840(queF)
CJV : MTVDSCj20_1694(queF)
CFV : CFVI03293_0005(queF)
CAMP : CFT03427_0005(queF)
CCOC : CCON33237_0004(queF)
CLR : UPTC16701_0011(queF)
CLM : UPTC16712_0011(queF)
CAMR : CAQ16704_0005(queF)
CHV : CHELV3228_0006(queF)
CPIN : CPIN18020_0005(queF)
CAMZ : CVIC12175_0004(queF)
BAMN : BASU_1310(queF) BASU_1314
BAMB : BAPNAU_2408(ykvM) BAPNAU_2411(queF)
BMP : NG74_01408(queF_1) NG74_01411(queF_2)
BAZ : BAMTA208_10260(queF)
BVM : B9C48_06920 B9C48_06940
BSON : S101395_03374 S101395_03383
BFD : NCTC4823_03009(queF)
BACW : QR42_02380 QR42_06495
BKW : BkAM31D_13405(queF_1) BkAM31D_13680(queF_2)
PARG : PspKH34_28200(queF)
BLEN : NCTC4824_01275(queF)
SUQ : HMPREF0772_12457(queF)
SUF : SARLGA251_06610(queF)
SAUT : SAI1T1_2005650(folE)
SAUJ : SAI2T2_1005670(folE)
SAUK : SAI3T3_1005660(folE)
SAUQ : SAI4T8_1005650(folE)
SAUV : SAI7S6_1005660(queF)
SAUW : SAI5S5_1005620(queF)
SAUX : SAI6T6_1005630(queF)
SAUY : SAI8T7_1005660(queF)
SDP : NCTC12225_02235(queF)
SPIC : SAMEA4384060_2143(queF)
SSH : NCTC13712_00693(queF)
SSIM : SAMEA4384339_0674(queF)
SSTE : SAMEA4384403_2089(queF)
BAYD : BSPP4475_04100(queF)
PNK : AASFL403_13930(queF)
ANX : ACH33_11300 ACH33_14220
SURL : BI350_06765 BI350_07080
SNC : HMPREF0837_12002(queF)
SPNG : HMPREF1038_01737(queF)
SVB : NCTC12167_00836(queF)
CGEL : psyc5s11_26560(queF)
CSCI : HDCHBGLK_02621(tilS_2)
CKN : Calkro_2473 Calkro_2475
CDIA : CaldiYA01_23350(queF)
VRM : 44547418_00148(queF)
VDN : NCTC11831_00135(queF)
DHO : Dia5BBH33_12330(queF)
PFAC : PFJ30894_01999(queF)
SYY : SYNGTS_2794(slr0711)
SYT : SYNGTI_2793(slr0711)
SYS : SYNPCCN_2792(slr0711)
SYQ : SYNPCCP_2792(slr0711)
SYNW : SynWH8103_00541(queF)
LSK : J5X98_06730 J5X98_23650(queF)
PRUN : PCC7821_00292(queF)
NSPH : BDGGKGIB_04293(queF)
DDR : Deide_00310 Deide_19030
DMR : Deima_0778 Deima_3136
OBG : Verru16b_01667(queF)
ABIW : Abiwalacus_22350(queF)
LCRE : Pla8534_37930(queF)
PPIO : CE91St28_00920(queF)
BTHO : Btheta7330_01503(queF)
BCEL : BcellWH2_04818(queF)
BFC : BacF7301_22850(queF)
PCRE : NCTC12858_00585(queF)
PCAG : NCTC12856_01068(queF)
PSOE : CE91St14_21110(queF)
COPR : Cop2CBH44_17690(queF)
CFAS : Cfast33896_21740(queF)
PMZ : HMPREF0659_A6013(queF)
PDN : HMPREF9137_1651(queF)
PHER : prwr041_05510(queF)
POC : NCTC13071_00335(queF)
ASX : CDL62_13830(queF) CDL62_17610
PROC : Ptc2401_00542(queF)
» show all
Taxonomy
Reference
Authors
Van Lanen SG, Reader JS, Swairjo MA, de Crecy-Lagard V, Lee B, Iwata-Reuyl D
Title
From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold.
Journal
Sequence
Reference
Authors
Yokoyama S, Miyazawa T, Iitaka Y, Yamaizumi Z, Kasai H, Nishimura S.
Title
Three-dimensional structure of hyper-modified nucleoside Q located in the wobbling position of tRNA.
Journal
Reference
Authors
Kuchino Y, Kasai H, Nihei K, Nishimura S.
Title
Biosynthesis of the modified nucleoside Q in transfer RNA.
Journal
Reference
Authors
Okada N, Noguchi S, Nishimura S, Ohgi T, Goto T, Crain PF, McCloskey JA.
Title
Structure determination of a nucleoside Q precursor isolated from E. coli tRNA: 7-(aminomethyl)-7-deazaguanosine.
Journal
Reference
Authors
Noguchi S, Yamaizumi Z, Ohgi T, Goto T, Nishimura Y, Hirota Y, Nishimura S.
Title
Isolation of Q nucleoside precursor present in tRNA of an E. coli mutant and its characterization as 7-(cyano)-7-deazaguanosine.
Journal
Reference
Authors
Swairjo MA, Reddy RR, Lee B, Van Lanen SG, Brown S, de Crecy-Lagard V, Iwata-Reuyl D, Schimmel P.
Title
Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.7.1.13
ExPASy - ENZYME nomenclature database: 1.7.1.13
LinkDB
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