Entry
Name
(RS)-norcoclaurine 6-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine [RN:
R05162 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
(R,S)-norcoclaurine [CPD:
C06346 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
(R,S)-coclaurine [CPD:
C06348 ]
Comment
The enzyme will also catalyse the 6-O-methylation of (RS)-norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this alkaloid has not been found to occur in plants.
History
EC 2.1.1.128 created 1999
Pathway
ec00950 Isoquinoline alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K13383 (RS)-norcoclaurine 6-O-methyltransferase
Genes
NNU : 104587969 104590844 104590845 104607696
MING : 122063497 122065300 122065301
MSIN : 131218590 131221173 131221300 131221321 131221496 131221561 131221623 131239724 131241129 131249901 131249922 131249944
Taxonomy
Reference
Authors
Rueffer M, Nagakura N, Zenk MH
Title
Partial Purification and Properties of S-Adenosylmethionine: (R), (S)-Norlaudanosoline-6-O-Methyltransferase from Argemone platyceras Cell Cultures.
Journal
Reference
Authors
Sato F, Tsujita T, Katagiri Y, Yoshida S, Yamada Y
Title
Purification and characterization of S-adenosyl-L-methionine: norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells.
Journal
Sequence
Reference
3
Authors
Stadler, R., Zenk, M.H.
Title
A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline.
Journal
Liebigs Ann Chem 555-562 (1990)
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.128
LinkDB
All DBs