KEGG ENZYME: 2.1.1.38

ENZYME: 2.1.1.38

Entry

EC 2.1.1.38                 Enzyme

Name

O-demethylpuromycin O-methyltransferase;
O-demethylpuromycin methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin [RN:R03633]

Reaction(KEGG)

R03633;
(other) R05676

Substrate

S-adenosyl-L-methionine [CPD:C00019];
O-demethylpuromycin [CPD:C02864]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
puromycin [CPD:C01610]

Comment

Puromycin is the antibiotic derived from N6-dimethyladenosine by replacing the 3'-hydroxy group with an amino group and acylating this with 4-O-methyltyrosine.

History

EC 2.1.1.38 created 1972

Pathway

ec00998

Biosynthesis of various antibiotics

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K12635

O-demethylpuromycin O-methyltransferase

Genes

SALW:

CP975_29310

Reference

1 [PMID:5773275]

Authors

Rao MM, Rebello PF, Pogell BM.

Title

Biosynthesis of puromycin in Streptomyces alboniger. Enzymatic methylation of O-demethylpuromycin.

Journal

J Biol Chem 244:112-8 (1969)

Sequence

[salw:CP975_29310]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.38

IUBMB Enzyme Nomenclature:

2.1.1.38

ExPASy - ENZYME nomenclature database:

2.1.1.38

BRENDA, the Enzyme Database:

2.1.1.38

CAS:	37257-04-8

LinkDB

DBGET integrated database retrieval system