KEGG   ENZYME: 2.1.1.54
Entry
EC 2.1.1.54                 Enzyme                                 
Name
deoxycytidylate C-methyltransferase;
deoxycytidylate methyltransferase;
dCMP methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
5,10-methylenetetrahydrofolate:dCMP C-methyltransferase
Reaction(IUBMB)
5,10-methylenetetrahydrofolate + dCMP = dihydrofolate + deoxy-5-methylcytidylate [RN:R01670]
Reaction(KEGG)
R01670
Substrate
5,10-methylenetetrahydrofolate [CPD:C00143];
dCMP [CPD:C00239]
Product
dihydrofolate [CPD:C00415];
deoxy-5-methylcytidylate [CPD:C03495]
Comment
dCMP is methylated by formaldehyde in the presence of tetrahydrofolate. CMP, dCTP and CTP can act as acceptors, but more slowly.
History
EC 2.1.1.54 created 1978
Reference
1  [PMID:980110]
  Authors
Kuo TT, Tu J.
  Title
Enzymatic synthesis of deoxy-5-methyl-cytidylic acid replacing deoxycytidylic acid in Xanthomonas oryzae phage Xp12DNA.
  Journal
Nature 263:615 (1976)
DOI:10.1038/263615a0
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.54
IUBMB Enzyme Nomenclature: 2.1.1.54
ExPASy - ENZYME nomenclature database: 2.1.1.54
BRENDA, the Enzyme Database: 2.1.1.54
CAS: 61970-01-2
LinkDB

DBGET integrated database retrieval system