KEGG ENZYME: 2.1.1.83

ENZYME: 2.1.1.83

Entry

EC 2.1.1.83                 Enzyme

Name

3,7-dimethylquercetin 4'-O-methyltransferase;
flavonol 4'-O-methyltransferase;
flavonol 4'-methyltransferase;
4'-OMT;
S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase;
3,7-dimethylquercitin 4'-O-methyltransferase [mis-spelt]

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + 5,3',4'-trihydroxy-3,7-dimethoxyflavone = S-adenosyl-L-homocysteine + 5,3'-dihydroxy-3,7,4'-trimethoxyflavone [RN:R03456]

Reaction(KEGG)

R03456

Substrate

S-adenosyl-L-methionine [CPD:C00019];
5,3',4'-trihydroxy-3,7-dimethoxyflavone

Product

S-adenosyl-L-homocysteine [CPD:C00021];
5,3'-dihydroxy-3,7,4'-trimethoxyflavone

Comment

3,7-Dimethylquercetagetin can also act as acceptor. Involved with EC 2.1.1.76 quercetin 3-O-methyltransferase and EC 2.1.1.82 3-methylquercetin 7-O-methyltransferase in the methylation of quercetin to 3,7,4'-trimethylquercetin in Chrysosplenium americanum. Does not act on flavones, dihydroflavonols, or their glucosides.

History

EC 2.1.1.83 created 1989

Pathway

ec00944

Flavone and flavonol biosynthesis

ec01110

Biosynthesis of secondary metabolites

Reference

1 [PMID:3994393]

Authors

De Luca V, Ibrahim RK

Title

Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. I. Partial purification and some properties of S-adenosyl-L-methionine:flavonol 3-, 6-, 7-, and 4'-O-methyltransferases.

Journal

Arch Biochem Biophys 238:596-605 (1985)
DOI:10.1016/0003-9861(85)90205-X

Reference

2 [PMID:3994394]

Authors

De Luca V, Ibrahim RK.

Title

Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. II. Substrate interaction and product inhibition studies of flavonol 3-, 6-, and 4'-O-methyltransferases.

Journal

Arch Biochem Biophys 238:606-18 (1985)
DOI:10.1016/0003-9861(85)90206-1

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.83

IUBMB Enzyme Nomenclature:

2.1.1.83

ExPASy - ENZYME nomenclature database:

2.1.1.83

BRENDA, the Enzyme Database:

2.1.1.83

CAS:	96477-60-0

LinkDB

DBGET integrated database retrieval system