| Entry |
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| Name |
tetrahydrocolumbamine 2-O-methyltransferase;
tetrahydrocolumbamine methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine = S-adenosyl-L-homocysteine + tetrahydropalmatine [RN: R04077]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
5,8,13,13a-tetrahydrocolumbamine [CPD: C04118]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
tetrahydropalmatine [CPD: C02890]
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| Comment |
Involved in the biosynthesis of the berberine alkaloids.
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| History |
EC 2.1.1.89 created 1989
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| Pathway |
| ec00950 | Isoquinoline alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Reference |
1 |
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| Authors |
Beecher, C.W.W. and Kelleher, W.J. |
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| Title |
Enzymatic study of the late stages of protoberberine alkaloid biosynthesis. |
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| Journal |
Tetrahedron Lett 25:4595-4598 (1984) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.1.1.89 |
| ExPASy - ENZYME nomenclature database: | 2.1.1.89 |
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| LinkDB |
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