KEGG   ENZYME: 2.1.1.97
Entry
EC 2.1.1.97                 Enzyme                                 
Name
3-hydroxyanthranilate 4-C-methyltransferase;
3-hydroxyanthranilate 4-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3-hydroxyanthranilate = S-adenosyl-L-homocysteine + 3-hydroxy-4-methylanthranilate [RN:R02667]
Reaction(KEGG)
R02667
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3-hydroxyanthranilate [CPD:C00632]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3-hydroxy-4-methylanthranilate [CPD:C03986]
Comment
Involved in the biosynthesis of the antibiotic actinomycin in Streptomyces antibioticus.
History
EC 2.1.1.97 created 1990
Reference
1  [PMID:2450873]
  Authors
Fawaz F, Jones GH.
  Title
Actinomycin synthesis in Streptomyces antibioticus. Purification and properties of a 3-hydroxyanthranilate 4-methyltransferase.
  Journal
J Biol Chem 263:4602-6 (1988)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.97
IUBMB Enzyme Nomenclature: 2.1.1.97
ExPASy - ENZYME nomenclature database: 2.1.1.97
BRENDA, the Enzyme Database: 2.1.1.97
CAS: 112445-22-4
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