| Entry |
|
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| Name |
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)
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| Reaction(IUBMB) |
3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2 [RN: R07250]
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| Reaction(KEGG) |
|
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| Substrate |
malonyl-CoA [CPD: C00083];
N-methylanthraniloyl-CoA [CPD: C12092]
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| Product |
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| Comment |
Belongs to a superfamily of plant polyketide synthases. Has many similarities to chalcone and stilbene synthases (see reaction synthesis)
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| History |
EC 2.3.1.159 created 2002
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| Pathway |
| ec00996 | Biosynthesis of various alkaloids |
| ec01110 | Biosynthesis of secondary metabolites |
|
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| Orthology |
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| Genes |
| CIC: | CICLE_v10025804mg CICLE_v10025807mg |
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| Reference |
|
|---|
| Authors |
Baumert A, Maier W, Groger D, Deutzmann R. |
|---|
| Title |
Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L. |
|---|
| Journal |
|
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| Reference |
2 |
|---|
| Authors |
Maier, W., Baumert, A., Schumann, B., Furukawa, H. and Groger, D. |
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| Title |
Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures. |
|---|
| Journal |
Phytochemistry 32:691-698 (1993) |
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| Reference |
|
|---|
| Authors |
Lukacin R, Springob K, Urbanke C, Ernwein C, Schroder G, Schroder J, Matern U. |
|---|
| Title |
Native acridone synthases I and II from Ruta graveolens L. form homodimers |
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| Journal |
|
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| Sequence |
|
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| Reference |
|
|---|
| Authors |
Junghanns KT, Kneusel RE, Groger D, Matern U. |
|---|
| Title |
Differential regulation and distribution of acridone synthase in Ruta graveolens. |
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| Journal |
|
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.3.1.159 |
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| LinkDB |
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