Entry
Name
6-methylsalicylic-acid synthase;
MSAS;
6-methylsalicylic acid synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)
Reaction(IUBMB)
acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O [RN:
R07253 ]
Reaction(KEGG)
Substrate
Product
Comment
A multienzyme complex with a tightly-bound 4'-phosphopantetheine cofactor on the acyl carrier protein. It has a similar sequence to vertebrate type I fatty acid synthase. Acetoacetyl-CoA can also act as a starter molecule.
History
EC 2.3.1.165 created 2002
Pathway
ec01059 Biosynthesis of enediyne antibiotics
ec01110 Biosynthesis of secondary metabolites
Orthology
K15320 6-methylsalicylic acid synthase
Genes
PCS : N7525_005421 N7525_011590
NPA : UCRNP2_4356 UCRNP2_6207 UCRNP2_8850
MGAU : MGALJ_22330(ppsA_2)
MPHL : MPHLCCUG_03492(ppsA_2)
MTHN : 4412656_02813(ppsA_3)
MAUU : NCTC10437_03653(ppsA_4)
MSEI : MSEDJ_48250(ppsA_2)
MFLV : NCTC10271_01760(ppsA_2)
NAD : NCTC11293_04860(ppsA_4)
SPRI : SPRI_0139 SPRI_7214
SGM : GCM10017557_73720(ppsA)
NOA : BKM31_19850 BKM31_21690
MCAB : HXZ27_04065(evdD3) HXZ27_20980
» show all
Taxonomy
Reference
Authors
Spencer JB, Jordan PM.
Title
Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum.
Journal
Reference
Authors
Child CJ, Spencer JB, Bhogal P, Shoolingin-Jordan PM.
Title
Structural similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: evidence from thiol modification studies.
Journal
Reference
Authors
Richardson MT, Pohl NL, Kealey JT, Khosla C.
Title
Tolerance and specificity of recombinant 6-methylsalicyclic acid synthase.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.165
LinkDB
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