KEGG ENZYME: 2.3.1.169

ENZYME: 2.3.1.169

Entry

EC 2.3.1.169                Enzyme

Name

CO-methylating acetyl-CoA synthase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:corrinoid protein O-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] [RN:R08433]

Reaction(KEGG)

R08433;
(other) R09317 R10243

Substrate

acetyl-CoA [CPD:C00024];
[Co(I) corrinoid Fe-S protein]

Product

CO [CPD:C00237];
CoA [CPD:C00010];
[methyl-Co(III) corrinoid Fe-S protein]

Comment

Contains nickel, copper and iron-sulfur clusters. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin), in the synthesis of acetyl-CoA from CO2 and H2.

History

EC 2.3.1.169 created 2003, modified 2015

Pathway

ec00720

Carbon fixation pathways in prokaryotes

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K00193

acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit beta

K14138

acetyl-CoA synthase

Genes

GEF:	FO488_05725

DSF:

UWK_03162

DLM:	DPPLL_26590

DAK:	DaAHT2_0825

DBK:	DGMP_17890

DDU:

GF1_14210

ECOM:

QTN59_00700(acsB)

DOL:

Dole_3184

DAL:

Dalk_0681

DAT:	HRM2_16660(cdhC)

DTO:	TOL2_C11810(cdhC)

DOV:	DSCO28_59730

DWD:	DSCW_28530

DALK:

DSCA_26720

DML:	Dmul_30850(cdhC)

DLI:	dnl_32610(cdhC)

DMM:	dnm_013320(cdhC)

DEK:	DSLASN_16760

DAO:	Desac_1967

DTI:	Desti_0231

SFU:

Sfum_2565

DAX:	FDQ92_06240(cdhC)

DBR:

Deba_0240

DMP:

FAK_42010

TID:	Thein_2183

TOP:	TOPB45_0394

TCM:	HL41_07625

THET:

F1847_08575(cdhC)

CTHI:

THC_1762

TAV:	G4V39_01655(cdhC)

TMAI:

FVE67_00230(cdhC)

DHR:	LGS26_01915(cdhC)

CLJ:	CLJU_c37550

CAH:	CAETHG_1608(acsB)

CSQ:

CSCA_4551

CACE:

CACET_c10320(acsB)

CCK:	Ccar_18785

CFM:	BJL90_11135

CDRK:

B9W14_22250

CLOS:

DMR38_18720(cdhC)

RGV:	NQ502_01500(acsB)

DSY:

DSY1652

DHD:

Dhaf_2797

DDH:	Desde_2255

DDL:	Desdi_1921

DMT:	DESME_07330

DOR:	Desor_3273

DAI:	Desaci_2974

DMI:	Desmer_2535

DED:	DHBDCA_p224

DEC:	DCF50_p284

DRS:	DEHRE_00705

DAE:	Dtox_1271 Dtox_3781

DKU:	Desku_1491 Desku_2149

DAU:	Daud_0111 Daud_0871

FWA:	DCMF_05865

AACX:

DEACI_2512

TJR:	TherJR_1158

DGI:	Desgi_0523 Desgi_1186 Desgi_2051

ELM:

ELI_3601

EMT:	CPZ25_018715(cdhC)

ELIM:

B2M23_08410

AWO:	Awo_c10760(acsB1) Awo_c33680(acsB2)

AWI:	CHL1_001322(cdhC) CHL1_002701(cdhC)

ALKA:

J0B03_11240(cdhC) J0B03_11265(cdhC)

CTHM:

CFE_1665

BYL:	A4V09_05460

BHAN:

CGC63_07970(cdhC)

BLAU:

DQQ01_09725(cdhC)

BPRO:

PMF13cell1_04283

BLAB:

EYS05_16725(cdhC)

BLIQ:

INP51_05955(cdhC)

BWX:	NQ550_13510(acsB) NQ550_13515(acsB)

BMAS:

LK422_06255(cdhC)

BLAR:

LC508_02765(cdhC) LC508_10480(cdhC)

BLUI:

Blut17040_19210(acsB_1) Blut17040_19220(acsB_2)

BCOC:

BLCOC_33110

BHV:	BLHYD_15400 BLHYD_15410 BLHYD_31730

QDO:	H9Q78_01470(cdhC)

WHJ:	H9Q79_03155(cdhC)

MFOR:

NQ534_19150(acsB)

AMT:

Amet_2028

GFE:	Gferi_06315

PBIF:

KXZ80_13900(cdhC)

PSOR:

RSJ16_15710

CDF:	CD630_07280

PDC:	CDIF630_00844(cdhC)

CDC:	CD196_0674

CDL:	CDR20291_0655

PDF:	CD630DERM_07280

ROC:	HF520_11260(cdhC)

TEM:	JW646_10895(cdhC)

TGC:	L0P85_16865(acsB)

TMY:	TEMA_26050(acsB)

TEB:

T8CH_0661

THYR:

P4S50_13870(acsB)

IBR:	NQ514_13085(acsB)

CST:	CLOST_1171

TKI:	TKV_c19820(acsB)

CHY:	CHY_1222(acsB)

ADG:

Adeg_0336

TPZ:	Tph_c15170(acsA)

AAUT:

ACETAC_10535(cdhC)

MTA:

Moth_1202

MTHO:

MOTHE_c11780

MTHZ:

MOTHA_c12650

TEP:	TepRe1_0561

TAE:	TepiRe1_0613

BACG:

D2962_12355(cdhC)

TOC:

Toce_0813

NCD:	ACONDI_02971

AAR:	Acear_1304

MANA:

MAMMFC1_00476

STED:

SPTER_05160 SPTER_13680

CALK:

HUE98_15620(cdhC)

DET:	DET0666 DET0700

DEH:	cbdbA652(codH)

DEB:	DehaBAV1_0635

DEV:	DhcVS_604(cdhC)

DEG:	DehalGT_0597

DMC:	btf_622(acsB)

DMD:	dcmb_668(acsB)

DMG:	GY50_0591(cdhC)

DMX:	X792_03230

DMY:	X793_02975

DMZ:	X794_02725

DUC:	UCH007_05840(acsB)

DLY:	Dehly_0817

DEW:	DGWBC_1386

DFO:	Dform_00887(acsB) Dform_00914(acsB)

DETH:

HX448_06200(cdhC)

KST:	KSMBR1_1325(codh_acsB)

BROC:

IPI25_11080(cdhC)

BPIT:

BPIT_02250

JET:	L3J17_07150(cdhC)

VAI:	BU251_01290

TPI:	TREPR_3067

TAZ:	TREAZ_1648

TYE:	THEYE_A1470

DTP:	JZK55_05480

MJA:	MJ_0152 MJ_0156

MFE:	Mefer_0200

MVU:	Metvu_0967 Metvu_1184

MFS:	MFS40622_0117 MFS40622_0121

MIF:	Metin_0081 Metin_1228

MJH:	JH146_0001 JH146_0005

MESG:

MLAUSG7_0548(cdhC) MLAUSG7_1300(cdhC)

MESA:

MLASG1_0247(cdhC) MLASG1_0900(cdhC)

MIG:	Metig_1378 Metig_1382

MMP:	MMP0983(cdhB)

MMQ:	MmarC5_0803

MMX:	MmarC6_1675

MMZ:	MmarC7_0225

MMD:

GYY_05740

MMAK:

MMKA1_11390(cdhC)

MMAO:

MMOS7_10750(cdhC)

MMAD:

MMJJ_00080

MAE:

Maeo_1171

MVN:	Mevan_0309

MOK:	Metok_0742 Metok_0743

METF:

CFE53_00285(cdhC) CFE53_03765(cdhC)

MTH:

MTH_1710

MMG:	MTBMA_c02890(cdhC)

MWO:	MWSIV6_0251(cdhC)

METC:

MTCT_1563

METE:

tca_01657

METK:

FVF72_03115(cdhC)

MTHM:

FZP57_01135(cdhC)

METJ:

FZP68_06140(cdhC)

MARO:

MarbSA_08790

MEL:	Metbo_0464

MEW:	MSWAN_1932

METH:

MBMB1_1563(cdhC)

MFC:	BRM9_0799(cdhC)

MFI:	DSM1535_0761(cdhC)

MCUB:

MCBB_1819(cdhC)

MSUB:

BK009_06800

METN:

BK008_02445

METT:

CIT01_07280(cdhC)

METO:

CIT02_10130(cdhC)

MEME:

HYG87_07910(cdhC)

MFEG:

GCM10025860_01010

MFV:

Mfer_0525

MKA:	MK0720(cdhC)

AFU:

AF_0379

AFG:	AFULGI_00003790

AVE:	Arcve_1123

AST:	Asulf_02027 Asulf_02202

FPL:	Ferp_0733 Ferp_0929

GAC:	GACE_0357 GACE_1720

GAH:	GAH_00919 GAH_01141

MBA:	Mbar_A0202 Mbar_A0432

MBY:	MSBRM_0626 MSBRM_2757

MBW:	MSBRW_0569 MSBRW_0794

MBAR:

MSBR2_1752 MSBR2_2715

MBAK:

MSBR3_2713 MSBR3_2953

MAC:	MA_1014(cdhC) MA_3862(cdhC)

MMA:	MM_0686 MM_2087

MMAZ:

MmTuc01_0702

MMJ:	MSMAS_0628 MSMAS_2598

MMAC:

MSMAC_0630 MSMAC_1822

MVC:	MSVAZ_0993 MSVAZ_3015

MEK:	MSKOL_0965 MSKOL_3022

MLS:	MSLAZ_0647

METM:

MSMTP_0685 MSMTP_0693

MEF:	MSWH1_0794

MEQ:	MSWHS_0846

MSJ:	MSSAC_3456 MSSAC_3599

MSZ:	MSSIH_2984 MSSIH_3139

MSW:	MSSIT_3042 MSSIT_3210

MTHR:

MSTHT_2338

MTHE:

MSTHC_0942

MHOR:

MSHOH_0737 MSHOH_3262

MFZ:	AOB57_003745(cdhC)

MBU:

Mbur_0860

MMET:

MCMEM_0992

MELO:

J7W08_03310(cdhC)

MMH:

Mmah_1168

MHAZ:

BHR79_07695

MPOT:

BKM01_03940

MEV:	Metev_0424

MZH:	Mzhil_1135

MPY:

Mpsy_2893

MZI:	HWN40_08235(cdhC)

MMAV:

RE476_02135(cdhC)

MSEB:

RE474_12030(cdhC)

MHZ:	Metho_0977

MEHF:

MmiHf6_01230

MEES:

MmiEs2_08400

MTP:

Mthe_0290

MCJ:	MCON_1330(cdhC) MCON_1942(cdhC)

MHI:	Mhar_0791 Mhar_2326

MHU:

Mhun_0688

MRTJ:

KHC33_09840(cdhC)

MBG:	BN140_2375(acsB)

MEMA:

MMAB1_3162

MCHK:

MchiMG62_09140

MRC:	R6Y96_05880(acsB)

MFK:	E2N92_11690(cdhC)

MBN:	Mboo_1196 Mboo_1371

MFO:	Metfor_1453 Metfor_1719

MPL:

Mpal_0803

RCI:	LRC459(cdhC)

MELU:

MTLP_05360

MER:	MMINT_19140

BARC:

AOA65_0452(cdhC2)

BARB:

AOA66_1430(cdhC2)

LOB:	NEF87_001879

» show all

Reference

1 [PMID:2984190]

Authors

Ragsdale SW, Wood HG.

Title

Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis.

Journal

J Biol Chem 260:3970-7 (1985)

Reference

2 [PMID:12386327]

Authors

Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL

Title

A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.

Journal

Science 298:567-72 (2002)
DOI:10.1126/science.1075843

Sequence

[mta:Moth_1202]