KEGG   ENZYME: 2.3.1.172
Entry
EC 2.3.1.172                Enzyme                                 
Name
anthocyanin 5-O-glucoside 6'''-O-malonyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
malonyl-CoA:pelargonidin-3-O-(6-caffeoyl-beta-D-glucoside)-5-O-beta-D-glucoside 6'''-O-malonyltransferase
Reaction(IUBMB)
malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin [RN:R06799]
Reaction(KEGG)
R06799;
(other) R07910
Substrate
malonyl-CoA [CPD:C00083];
pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside [CPD:C12640]
Product
CoA [CPD:C00010];
4'''-demalonylsalvianin [CPD:C12641]
Comment
Specific for the penultimate step in salvianin biosynthesis. The enzyme also catalyses the malonylation of shisonin to malonylshisonin [cyanidin 3-O-(6''-O-p-coumaryl-beta-D-glucoside)-5-(6'''-O-malonyl-beta-D-glucoside)]. The compounds 4'''-demalonylsalvianin, salvianin, pelargonidin 3,5-diglucoside and delphinidin 3,5-diglucoside cannot act as substrates.
History
EC 2.3.1.172 created 2004
Pathway
ec00942  Anthocyanin biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K12934  anthocyanin 5-O-glucoside-6'''-O-malonyltransferase
Genes
SSPL: 121759295
SHIS: 125193377
Reference
1  [PMID:11598135]
  Authors
Suzuki H, Nakayama T, Yonekura-Sakakibara K, Fukui Y, Nakamura N, Nakao M, Tanaka Y, Yamaguchi MA, Kusumi T, Nishino T
  Title
Malonyl-CoA:anthocyanin 5-O-glucoside-6"'-O-malonyltransferase from scarlet sage (Salvia splendens) flowers. Enzyme purification, gene cloning, expression, and characterization.
  Journal
J Biol Chem 276:49013-9 (2001)
DOI:10.1074/jbc.M108444200
  Sequence
[ag:AAL50566]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.172
IUBMB Enzyme Nomenclature: 2.3.1.172
ExPASy - ENZYME nomenclature database: 2.3.1.172
BRENDA, the Enzyme Database: 2.3.1.172
CAS: 380229-66-3
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