KEGG   ENZYME: 2.5.1.52
Entry
EC 2.5.1.52                 Enzyme                                 
Name
L-mimosine synthase;
O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl);
3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase;
O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase
Reaction(IUBMB)
O-acetyl-L-serine + 3,4-dihydroxypyridine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate [RN:R04091]
Reaction(KEGG)
R04091
Substrate
O-acetyl-L-serine [CPD:C00979];
3,4-dihydroxypyridine [CPD:C02932]
Product
3-(3,4-dihydroxypyridin-1-yl)-L-alanine [CPD:C04446];
acetate [CPD:C00033]
Comment
Brings about the biosynthesis of L-mimosine in plants of the Mimosa and Leucaena genera. Not identical with EC 2.5.1.51, beta-pyrazolylalanine synthase.
History
EC 2.5.1.52 created 1989 as EC 4.2.99.15, transferred 2002 to EC 2.5.1.52
Reference
1
  Authors
Murakoshi, I., Ikegami, F., Hinuma, Y. and Hanma, Y.
  Title
Purification and characterization of beta-(pyrazol-1-yl)-L-alanine synthase from Citrullus vulgaris.
  Journal
Phytochemistry 23:973-977 (1984)
Reference
2
  Authors
Murakoshi, I., Ikegami, F., Hinuma, Y. and Hanma, Y.
  Title
Purification and characterization of L-mimosine synthase from Leucaena leucocephala.
  Journal
Phytochemistry 23:1905-1908 (1984)
Reference
3
  Authors
Murakoshi, I., Kuramoto, H. and Haginiwa, J.
  Title
The enzymic synthesis of beta-substituted alanines.
  Journal
Phytochemistry 11:177-182 (1972)
Reference
4  [PMID:8280125]
  Authors
Noji M, Murakoshi I, Saito K
  Title
Evidence for identity of beta-pyrazolealanine synthase with cysteine synthase in watermelon: formation of beta-pyrazole-alanine by cloned cysteine synthase in vitro and in vivo.
  Journal
Biochem Biophys Res Commun 197:1111-7 (1993)
DOI:10.1006/bbrc.1993.2592
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.52
IUBMB Enzyme Nomenclature: 2.5.1.52
ExPASy - ENZYME nomenclature database: 2.5.1.52
BRENDA, the Enzyme Database: 2.5.1.52
CAS: 93229-75-5
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