KEGG ENZYME: 2.6.1.26

ENZYME: 2.6.1.26

Entry

EC 2.6.1.26                 Enzyme

Name

thyroid-hormone transaminase;
3,5-dinitrotyrosine transaminase;
thyroid hormone aminotransferase

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase

Reaction(IUBMB)

L-3,5,3'-triiodothyronine + 2-oxoglutarate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate [RN:R03952]

Reaction(KEGG)

R03952

Substrate

L-3,5,3'-triiodothyronine [CPD:C02465];
2-oxoglutarate [CPD:C00026]

Product

3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate [CPD:C03832];
L-glutamate [CPD:C00025]

Comment

A pyridoxal-phosphate protein. Acts on monoiodotyrosine, diiodotyrosine, triiodothyronine, thyroxine and dinitrotyrosine (unlike EC 2.6.1.24 diiodotyrosine transaminase, which does not act on dinitrotyrosine). Pyruvate or oxaloacetate can act as acceptors.

History

EC 2.6.1.26 created 1972

Reference

1 [PMID:4686924]

Authors

Soffer RL, Hechtman P, Savage M.

Title

L-Triiodothyronine aminotransferase.

Journal

J Biol Chem 248:1224-30 (1973)

Other DBs

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