KEGG ENZYME: 2.6.1.33

ENZYME: 2.6.1.33

Entry

EC 2.6.1.33                 Enzyme

Name

dTDP-4-amino-4,6-dideoxy-D-glucose transaminase;
thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase;
thymidine diphospho-4-amino-6-deoxyglucose aminotransferase;
thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase;
thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase;
TDP-4-keto-6-deoxy-D-glucose transaminase;
VioA;
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

dTDP-4-amino-4,6-dideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase

Reaction(IUBMB)

dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate [RN:R02773]

Reaction(KEGG)

R02773;
(other) R02772

Substrate

dTDP-4-amino-4,6-dideoxy-alpha-D-glucose [CPD:C04268];
2-oxoglutarate [CPD:C00026]

Product

dTDP-4-dehydro-6-deoxy-alpha-D-glucose [CPD:C11907];
L-glutamate [CPD:C00025]

Comment

A pyridoxal-phosphate protein.

History

EC 2.6.1.33 created 1972

Pathway

ec00523

Polyketide sugar unit biosynthesis

ec00525

Acarbose and validamycin biosynthesis

ec00541

O-Antigen nucleotide sugar biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K13308

dTDP-4-amino-4,6-dideoxy-D-glucose transaminase

K20428

dTDP-4-amino-4,6-dideoxy-D-glucose transaminase

K20429

dTDP-4-amino-4,6-dideoxy-D-glucose transaminase

K21328

dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase

Genes

ECT:	ECIAI39_0979(vioA)

EOC:	CE10_2353(vioA)

EBR:	ECB_01942(vioA)

ECOB:

C3029_14350

EBL:	ECD_01942(vioA)

EBE:	B21_01931(ybl97)

EBD:

ECBD_1619

SHQ:	A0259_14015

ESH:	C1N69_14925

PDZ:	HHA33_11055

EBB:

F652_1773

PAY:	PAU_04327(vioA)

HAV:	AT03_13955

SHE:	Shewmr4_1321

SHW:	Sputw3181_1468

SCHK:

GII14_07745

THAT:

H3N35_23260

TVD:	SG34_025420

PAEW:

KIH87_05075

CJA:

CJA_3257

AHI:	VU14_07300

ASAA:

KXJ75_15915(vioA)

SCOM:

PYG29_10110

CTEZ:

CT3_36500 CT3_36510

SUR:	STAUR_1378(gacV)

CSUA:

IM538_21580 IM538_21585

SCYE:

R2B67_24620

SGU:	SGLAU_00985(gacV)

STRE:

GZL_03714

SXI:	SXIM_35940

STRM:

M444_29855

SCAD:

DN051_13755

SNR:	SNOUR_10120(eryCIV)

SGF:	HEP81_07915

SGX:	H4W23_25490

SATA:

C5746_38530

SROI:

IAG44_16020

SHK:	J2N69_01045

SGK:	PET44_28275

SYUN:

MOV08_16445

STRH:

GXP74_26620

AER:	AERYTH_15840

NFS:	OIE67_22410

SEN:	SACE_0716(eryCIV)

KAL:	KALB_4714 KALB_6578(acuN2)

KUT:	JJ691_31610

STP:	Strop_2221

SAQ:	Sare_2034 Sare_2945

MCAB:

HXZ27_06180(rosQ)

ASE:	ACPL_3667(acbV)

AEY:	CDG81_13210

BFH:	F1611_19170 F1611_19175

MJJ:	PQO05_04315

HMT:	MTP16_12000

HSK:	H4317_15125

MHAA:

Q3Y49_04760 Q3Y49_04765

CHRC:

QGN23_07260 QGN23_07265

MOX:

DAMO_2610

» show all

Reference

1 [PMID:5332731]

Authors

Matsuhashi M, Strominger JL.

Title

Thymidine diphosphate 4-acetamido-2,6-dideoxyhexoses. 3. Purification and properties of thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase from Escherichia coli strain B.

Journal

J Biol Chem 241:4738-44 (1966)

Reference

2 [PMID:17905981]

Authors

Wang Y, Xu Y, Perepelov AV, Qi Y, Knirel YA, Wang L, Feng L

Title

Biochemical characterization of dTDP-D-Qui4N and dTDP-D-Qui4NAc biosynthetic pathways in Shigella dysenteriae type 7 and Escherichia coli O7.

Journal

J Bacteriol 189:8626-35 (2007)
DOI:10.1128/JB.00777-07

Sequence

[ag:AAD44154 AAR97958]