KEGG ENZYME: 2.6.1.74

ENZYME: 2.6.1.74

Entry

EC 2.6.1.74                 Enzyme

Name

cephalosporin-C transaminase;
cephalosporin C aminotransferase;
L-alanine:cephalosporin-C aminotransferase

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

cephalosporin-C:2-oxoglutarate aminotransferase

Reaction(IUBMB)

(7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate + D-glutamate = cephalosporin C + 2-oxoglutarate [RN:R03063]

Reaction(KEGG)

R03063

Substrate

(7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate [CPD:C04712];
D-glutamate [CPD:C00217]

Product

cephalosporin C [CPD:C00916];
2-oxoglutarate [CPD:C00026]

Comment

A number of D-amino acids, including D-alanine, D-aspartate and D-methionine can also act as amino-group donors. Although this enzyme acts on several free D-amino acids, it differs from EC 2.6.1.21, D-alanine transaminase, in that it can use cephalosporin C as an amino donor.

History

EC 2.6.1.74 created 1992, modified 2005

Pathway

ec00311

Penicillin and cephalosporin biosynthesis

ec01110

Biosynthesis of secondary metabolites

Reference

1 [PMID:3228235]

Authors

Aretz W, Sauber K.

Title