KEGG   ENZYME: 2.7.7.64
Entry
EC 2.7.7.64                 Enzyme                                 
Name
UTP-monosaccharide-1-phosphate uridylyltransferase;
UDP-sugar pyrophosphorylase;
PsUSP
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Reaction(IUBMB)
UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide [RN:R08845]
Reaction(KEGG)
R08845 > R00289 R00502 R01381 R01471 R03077
Substrate
UTP [CPD:C00075];
monosaccharide 1-phosphate [CPD:C00991]
Product
diphosphate [CPD:C00013];
UDP-monosaccharide [CPD:C05227]
Comment
Requires Mg2+ or Mn2+ for maximal activity. The reaction can occur in either direction and it has been postulated that MgUTP and Mg-diphosphate are the actual substrates [1,2]. The enzyme catalyses the formation of UDP-Glc, UDP-Gal, UDP-GlcA, UDP-L-Ara and UDP-Xyl, showing broad substrate specificity towards monosaccharide 1-phosphates. Mannose 1-phosphate, L-Fucose 1-phosphate and glucose 6-phosphate are not substrates and UTP cannot be replaced by other nucleotide triphosphates [1].
History
EC 2.7.7.64 created 2006
Pathway
ec00040  Pentose and glucuronate interconversions
ec00052  Galactose metabolism
ec00053  Ascorbate and aldarate metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12447  UDP-sugar pyrophosphorylase
Genes
ATH: AT5G52560(USP)
ALY: 9301995
CRB: 17875462
CSAT: 104725768 104727645 104761268 109127935
EUS: EUTSA_v10000457mg
BRP: 103842186
BNA: 106368564 106415929
BOE: 106307311 106336398
RSZ: 108805857
THJ: 104808371
CPAP: 110813513
CIT: 102628031
CIC: CICLE_v10000592mg
PVY: 116116047 116140087
MINC: 123203258 123206225
TCC: 18592423
GRA: 105783427 105792654
GHI: 107897588 107938693 107939552 107949516
GAB: 108462975 108467534
HSYR: 120207178
DZI: 111298632 111312249
EGR: 104450548
GMX: 100793599 778158(USP1)
GSJ: 114410378 114415459
PVU: PHAVU_009G130500g
VRA: 106762599
VAR: 108332148
VUN: 114164681
VUM: 124826520
CCAJ: 109796895
APRC: 113869536
MTR: 25489712
TPRA: 123909387
CAM: 101505137
PSAT: 127082747
VVO: 131626432 131661385
LJA: Lj0g3v0214629.1(Lj0g3v0214629.1) Lj0g3v0214629.2(Lj0g3v0214629.2)
ADU: 107460668
AIP: 107606001
AHF: 112706017 112764737 114927234
LANG: 109344323
PCIN: 129294265 129304189
QSA: O6P43_015120 O6P43_019795
FVE: 101297604
RCN: 112172726
PPER: 18790905
PMUM: 103319759
PAVI: 110766413
PDUL: 117614229
MDM: 103456258
MSYL: 126604195
PXB: 103945204 103946766
ZJU: 107421126
MNT: 21387354
CSAV: 115698731 115709730
CSV: 101202798
CMO: 103485690
BHJ: 120075699
MCHA: 111011819
CMAX: 111487149
CMOS: 111462581
CPEP: 111802306
RCU: 8270969
JCU: 105639006
HBR: 110632622 110647558
MESC: 110606169
POP: 7467856
PEU: 105127743
PALZ: 118061551
JRE: 109004826 109012130
CILL: 122296207 122299491
CAVE: 132185829
QSU: 111984090 111999283
QLO: 115960014
TWL: 119996987 120017142
VVI: 100259254
VRI: 117906610
SLY: 101247010
SPEN: 107018439
SOT: 102596087
SSTN: 125849909
SDUL: 129902203
CANN: 107852493
LBB: 132627176
NTA: 107804078 107808766
NSY: 104232978
NTO: 104119089
NAU: 109234273
INI: 109170461
ITR: 116014919
SIND: 105180105
OEU: 111397495 111408714
EGT: 105963411
SSPL: 121783004 121785967 121810605
SMIL: 131011810
SHIS: 125208178 125218199
APAN: 127246463
HAN: 110904244 110927044
ECAD: 122603150 122609402
LSV: 111901456
CCAV: 112522223 112523107
DCR: 108204601
CSIN: 114267052
RVL: 131307323
AEW: 130758359 130776324
BVG: 104894442
SOE: 110782013
CQI: 110685928 110725744
ATRI: 130818202
MOF: 131162338
NNU: 104606683
MING: 122072129 122094797
TSS: 122655413 122657876 122670080
PSOM: 113291734 113326815 113332494 113358220
OSA: 4341967
DOSA: Os06t0701200-01(Os06g0701200)
OBR: 102704348
OGL: 127777429
BDI: 100845164
ATS: 109751835
TDC: 119329157 119337370
TAES: 123148643 123157133 123163925
TUA: 125519710
LPER: 127312522 127324064
LRD: 124684174 124692501 124692520 124697546
SBI: 8065566
ZMA: 100285949 100382378 103625925 109939773
SITA: 101760295 101768879
SVS: 117854042 117863004
PVIR: 120668692 120704388
PHAI: 112888690
PDA: 103713110
EGU: 105049301
MUS: 103985547 103997892
ZOF: 121970675 121975759 121988662 121997589
DCT: 110114106
PEQ: 110033390
AOF: 109850719
MSIN: 131221063 131226735
NCOL: 116261024
ATR: 18424675
SMO: SELMODRAFT_100378 SELMODRAFT_118485
PPP: 112284456 112291294
CRE: CHLRE_14g621751v5
VCN: VOLCADRAFT_120799
CSL: COCSUDRAFT_53808
CVR: CHLNCDRAFT_35169
APRO: F751_3978
OLU: OSTLU_51241 OSTLU_52106
OTA: OT_ostta13g02030
BPG: Bathy17g01210
MIS: MICPUN_106965
MPP: MICPUCDRAFT_60817(JGI:MicpuC2_60817)
PFA: PF3D7_0517500
PFD: PFDG_01194
PFH: PFHG_00237
PREI: PRSY57_0008200
PGAB: PGSY75_0517500
PYO: PY17X_1235700
PCB: PCHAS_1232900
PBE: PBANKA_1232300
PVV: PVVCY_1203320
PKN: PKNH_1015800
PVX: PVX_080375
PCY: PCYB_102430
PMAL: PMUG01_10027200
PREL: PRELSG_1014400
CPV: cgd7_1830
CHO: Chro.70213
TGO: TGME49_218200
TET: TTHERM_00929520 TTHERM_00951720
PTM: GSPATT00032995001
SMIN: v1.2.004770.t1(symbB.v1.2.004770.t1) v1.2.004770.t2(symbB.v1.2.004770.t2) v1.2.011414.t1(symbB.v1.2.011414.t1)
PTI: PHATRDRAFT_23639 PHATRDRAFT_54493
FCY: FRACYDRAFT_211962(USP2) FRACYDRAFT_237242(USP1)
TPS: THAPSDRAFT_13482 THAPSDRAFT_42326
AAF: AURANDRAFT_22705 AURANDRAFT_23667 AURANDRAFT_28944 AURANDRAFT_70780
PIF: PITG_10315
PSOJ: PHYSODRAFT_312734
EHX: EMIHUDRAFT_426133 EMIHUDRAFT_427850 EMIHUDRAFT_454930 EMIHUDRAFT_51739 EMIHUDRAFT_68020 EMIHUDRAFT_74985
GTT: GUITHDRAFT_115181 GUITHDRAFT_157482 GUITHDRAFT_159419
TCR: 503493.10 511761.10
LMA: LMJF_17_1160(USP)
LIF: LINJ_17_1260(USP)
LDO: LDBPK_171260
LMI: LMXM_17_1160
LBZ: LBRM_17_1270(USP)
LPAN: LPMP_171130(USP)
CAA: Caka_1908
VBS: EGM51_17175
 » show all
Reference
1  [PMID:15326166]
  Authors
Kotake T, Yamaguchi D, Ohzono H, Hojo S, Kaneko S, Ishida HK, Tsumuraya Y
  Title
UDP-sugar pyrophosphorylase with broad substrate specificity toward various monosaccharide 1-phosphates from pea sprouts.
  Journal
J Biol Chem 279:45728-36 (2004)
DOI:10.1074/jbc.M408716200
  Sequence
[ag:BAD66876]
Reference
2  [PMID:4430676]
  Authors
Rudick VL, Weisman RA.
  Title
Uridine diphosphate glucose pyrophosphorylase of Acanthamoeba castellanii. Purification, kinetic, and developmental studies.
  Journal
J Biol Chem 249:7832-40 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.64
IUBMB Enzyme Nomenclature: 2.7.7.64
ExPASy - ENZYME nomenclature database: 2.7.7.64
BRENDA, the Enzyme Database: 2.7.7.64
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