KEGG ENZYME: 2.7.7.67

ENZYME: 2.7.7.67

Entry

EC 2.7.7.67                 Enzyme

Name

CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase;
carS (gene name);
CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase;
CTP:2,3-GG-GP ether cytidylyltransferase;
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase;
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol synthase;
CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase;
CDP-unsaturated archaeol synthase;
CDP-archaeol synthase (incorrect)

Class

Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases

Sysname

CTP:2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate cytidylyltransferase

Reaction(IUBMB)

CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol [RN:R08966]

Reaction(KEGG)

R08966

Substrate

CTP [CPD:C00063];
2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate [CPD:C04638]

Product

diphosphate [CPD:C00013];
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol [CPD:C18059]

Comment

This enzyme catalyses one of the steps in the biosynthesis of polar lipids in archaea, which are characterized by having an sn-glycerol 1-phosphate backbone rather than an sn-glycerol 3-phosphate backbone as is found in bacteria and eukaryotes [1]. The enzyme requires Mg2+ and K+ for maximal activity [1].

History

EC 2.7.7.67 created 2009, modified 2014

Pathway

ec00564

Glycerophospholipid metabolism

ec01110

Biosynthesis of secondary metabolites

Orthology

K19664

CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase

Genes

MJA:

MJ_1600

MFE:	Mefer_0314

MVU:	Metvu_1168

MFS:	MFS40622_0461

MIF:	Metin_0009

MJH:	JH146_0423

MESG:

MLAUSG7_0489(carS)

MESA:

MLASG1_0023(carS)

MIG:	Metig_0925

MMP:

MMP1698

MMQ:	MmarC5_1708

MMX:	MmarC6_0973

MMZ:	MmarC7_0973

MMD:

GYY_09365

MMAK:

MMKA1_19320

MMAO:

MMOS7_18130

MMAD:

MMJJ_11310

MAE:

Maeo_1211

MVN:	Mevan_1000

MVO:

Mvol_1258

MOK:	Metok_0824

METF:

CFE53_06750

MTH:

MTH_832

MMG:	MTBMA_c12300

MWO:	MWSIV6_1209(carS)

MTEE:

MTTB_05420

METC:

MTCT_0746

METE:

tca_00799

METZ:

METMT2_0906

METK:

FVF72_07380

MTHM:

FZP57_05740

METJ:

FZP68_00465

MST:

Msp_0385

METB:

AW729_05145

MEIS:

PXD04_05735

MRU:

mru_1693

MSI:

Msm_0850

MEB:

Abm4_0509

MMIL:

sm9_1776

MEYE:

TL18_07940

MOL:

YLM1_1161

MARO:

MarbSA_18770

METV:

K4897_07230

MEL:	Metbo_1947

MEW:	MSWAN_0673

METH:

MBMB1_0693

MFC:

BRM9_1502

MFI:	DSM1535_2196

MCUB:

MCBB_0704(carS)

MSUB:

BK009_01685

METN:

BK008_09240

METT:

CIT01_01970

METO:

CIT02_03305

MEME:

HYG87_03495

MFEG:

GCM10025860_17630

MFV:

Mfer_0208

MKA:	MK1073(cdsA)

AFU:

AF_1740

AFG:	AFULGI_00019910

APO:	Arcpr_0281

AVE:	Arcve_0687

AST:	Asulf_00219

FPL:

Ferp_2014

GAC:

GACE_1587

GAH:

GAH_00166

PFU:

PF0398

PFI:

PFC_01075

PHO:	PH0343(PH0343)

PAB:

PAB1285

PYN:

PNA2_0955

PYA:	PYCH_18060

PYS:

Py04_0654

PYC:	TQ32_03610

TKO:

TK2119

TON:

TON_1624

TGA:

TGAM_2129

TSI:

TSIB_1853

TBA:	TERMP_01811

THE:

GQS_07300

THA:

TAM4_297

THM:

CL1_1098

TLT:

OCC_07371

THS:

TES1_1802

TNU:

BD01_1847

TEU:

TEU_02180

TGY:	X802_04005

THV:	ADU37_CDS19710

TCH:	CHITON_1171

TPEP:

A0127_05530

TPIE:

A7C91_04030

TGG:	A3K92_00075

TCE:	A3L02_07560

TBS:	A3L01_08940

THH:	CDI07_08925

TSL:	A3L11_02440

TTD:	A3L14_00005

TPRF:

A3L09_01895

TRL:	A3L10_08420

TPAF:

A3L08_01940

THY:	A3L12_04655

TIC:	FH039_00555

TCQ:	TIRI35C_2131(carS)

THEM:

FPV09_08795

THEI:

K1720_01960

PPAC:

PAP_07885

MBA:	Mbar_A3516

MBY:	MSBRM_2321

MBW:	MSBRW_1219

MBAR:

MSBR2_0091

MBAK:

MSBR3_0103

MAC:

MA_3306

MMA:

MM_0141

MMAZ:

MmTuc01_0153

MMJ:	MSMAS_1191

MMAC:

MSMAC_2529

MVC:	MSVAZ_2285

MEK:	MSKOL_2290

MLS:	MSLAZ_1594

METM:

MSMTP_1153

MEF:	MSWH1_1030

MEQ:	MSWHS_1101

MSJ:	MSSAC_1616

MSZ:	MSSIH_1212

MSW:	MSSIT_1269

MTHR:

MSTHT_0110

MTHE:

MSTHC_0619

MHOR:

MSHOH_1382

MFZ:	AOB57_001935

MBU:

Mbur_1051

MMET:

MCMEM_1528

MELO:

J7W08_06450

MMH:

Mmah_0606

MHAZ:

BHR79_00340

MPOT:

BKM01_08055

MEV:	Metev_0876

MZH:	Mzhil_0625

MPY:

Mpsy_1082

MZI:	HWN40_03105

MMAV:

RE476_07140

MSEB:

RE474_03415

MHZ:	Metho_1973

MEHF:

MmiHf6_07190

MEES:

MmiEs2_02490

MTP:

Mthe_1386

MCJ:

MCON_1076

MHI:

Mhar_2089

MHU:

Mhun_1107

MRTJ:

KHC33_08590

MLA:

Mlab_0318

MEM:	Memar_1002

MBG:	BN140_1933

MEMA:

MMAB1_2497

MCHK:

MchiMG62_11260

MSUM:

OH143_11735

MRC:	R6Y96_08380

MPI:

Mpet_1312

MEND:

L6E24_13515

MEFW:

F1737_05295

MAQE:

RJ40_12810

MFK:	E2N92_12990

MOU:	OU421_10830

MESB:

L1S32_02820

MANQ:

L1994_06220

MBN:

Mboo_0842

MFO:	Metfor_2119

MPL:

Mpal_2361

MPD:	MCP_0607 MCP_2595

MEZ:

Mtc_0822

RCI:

RCIX520

HAL:

VNG_2119C

HSL:

OE_3954R

HANR:

LJ422_08515

HDL:	HALDL1_15495

HHB:

Hhub_3406

HAGS:

JT689_09865

HABO:

JRZ79_08245

HNO:	LT974_13850

HLU:	LT972_00880

HALH:

HTSR_0279

HHSR:

HSR6_0265

HSU:	HLASF_0224

HSF:	HLASA_0224

HAHS:

HSRCO_0358(cdsA)

SALR:

FQU85_05585

HALR:

EFA46_002575

HJE:	HacjB3_01055

HDO:	MUK72_04835

HALX:

M0R89_06980

HAXZ:

M0R88_07195

HAYC:

NGM10_09100

HAXY:

NGM07_13020

SALI:

L593_07400

SAIM:

K0C01_05575

HARA:

AArcS_0768(cdsA)

HMA:

rrnAC3084

HHI:

HAH_0338

HHN:	HISP_01775

HAB:	SG26_09585

HTA:	BVU17_01625

HALJ:

G9465_01085

HSIN:

KDQ40_11990

NPH:	NP_0990A(carS)

NMO:

Nmlp_1221

NHO:	HWV23_06655

NSAL:

HWV07_08100

HUT:

Huta_0926

HTI:

HTIA_0779

HALA:

Hrd1104_08500

HASV:

SVXHr_0699(carS)

HABN:

HBNXHr_0679(carS)

HMU:

Hmuk_1106

HALZ:

E5139_08705

HALL:

LC1Hm_0133(cdsA)

HAZP:

GBQ70_08700

HALI:

BV210_09040

HSN:	DV733_03100

HDS:	HSR122_2475(cdsA)

HRR:	HZS55_01305

HPEL:

HZS54_07860

HLT:	I7X12_13735

HARC:

HARCEL1_02255

SSAI:

N0B31_18800 N0B31_20835

HAAD:

MW046_03900

HWA:	HQ_3230A(carS)

HWC:	Hqrw_3793(carS)

HVO:	HVO_0332(carS)

HME:	HFX_0317(cdsA)

HGI:	ABY42_01495

HALE:

G3A49_01875

HLS:	KU306_06355

HLN:	SVXHx_0313(cdsa)

HBO:	Hbor_28390

HAQ:	DU484_04905

HAJ:	DU500_05345

HAER:

DU502_02315

HRA:	EI982_11225

HLM:	DV707_02600

HALM:

FCF25_08475

HLA:

Hlac_0350

HALP:

DOS48_01325

HALB:

EKH57_10365

HEZZ:

EO776_01060

HALQ:

Hrr1229_005880

HSS:	J7656_00110

HSAI:

HPS36_05630

HAZZ:

KI388_14745

HAE:	halTADL_3310

HALN:

B4589_009605

HALG:

HUG10_18095

HALU:

HUG12_18125

HMP:	K6T50_13235

HRE:	K6T36_13150

HRM:	K6T25_03505

HACB:

Hbl1158_05070

HDF:	AArcSl_3278(carS)

HAH:	Halar_3075

HTU:

Htur_2944

HSAL:

JMJ58_13715

HAKZ:

J0X25_01340

NMG:	Nmag_0950(carS)

HXA:	Halxa_2276

NAT:

NJ7G_2173

NPE:	Natpe_0776

NVR:	FEJ81_04030

NPL:	FGF80_06785

NAY:	HYG81_06965

HALY:

HYG82_09930

HJT:	DVR14_13190

HLO:	J0X27_13495

NGE:	Natgr_2464

HRU:	Halru_2249

SAWL:

NGM29_12490

HALV:

NGM15_04345

NOU:	Natoc_2624

HLR:	HALLA_07340

HLC:	CHINAEXTREME09215

NAJ:	B1756_13205

NAG:	AArcMg_2879

NAN:	AArc1_0823

NARA:

QQ977_02690

NBG:	DV706_10730

NAS:	GCU68_01330

HDA:	BB347_08885

MELU:

MTLP_10280

MEAM:

MU439_04885

MEAE:

QEN48_05280

TAC:

Ta0107

TVO:	TVG0192666(TVG0192666)

PTO:

PTO1104

FAC:	FACI_IFERC01G0999

FAI:

FAD_0022

CDIV:

CPM_1888

TAR:	TALC_00225

MAX:	MMALV_02110

MER:	MMINT_01920

MEAR:

Mpt1_c12490

MEUZ:

KRP56_01170

MARC:

AR505_1616

ABI:

Aboo_1071

ACF:	AciM339_1212

APE:

APE_0433

ACJ:

ACAM_0313

SMR:

Smar_0617

SHC:	Shell_0178

IHO:

Igni_0763

IIS:

EYM_07025

IPC:

IPA_06050

DKA:

DKAM_0148

DFD:	Desfe_0223

DMU:	Desmu_0699

TAG:

Tagg_1160

IAG:

Igag_1133

THG:	TCELL_0129

HBU:

Hbut_1639

PFM:	Pyrfu_0189

PDL:	Pyrde_0508

PABI:

PABY_02600

PARE:

PYJP_14570

STO:

STK_04650

SOH:	D1869_02140

SSO:

SSO0776

SOL:

Ssol_1837

SSOA:

SULA_1867

SSOL:

SULB_1868

SSOF:

SULC_1866

SSHI:

J5U23_02626

SCAS:

SACC_07160

SAI:

Saci_0897

SACN:

SacN8_04345

SACR:

SacRon12I_04335

SACS:

SUSAZ_04095

SIS:	LS215_1460

SIA:	M1425_1364

SIM:	M1627_1414

SID:

M164_1356

SIY:	YG5714_1358

SIN:	YN1551_1483

SII:

LD85_1487

SIH:

SiH_1309

SIR:

SiRe_1225

SIC:

SiL_1222

SULA:

BFU36_02225

SULE:

GFS03_07630

SULO:

GFS33_13035

SULL:

EWF20_03665

MSE:

Msed_2040

MEMJ:

MJ1HA_2310

MCN:

Mcup_0242

MHK:	DFR87_08285

MPRU:

DFR88_07960

MTEN:

GWK48_03550

MJN:	MjAS7_0341

AHO:

Ahos_0527

AMAN:

B6F84_06305

ABRI:

DFR85_08305

ASUL:

DFR86_05365

AAMB:

D1866_10330

ACIH:

HS5_18930

SACD:

HS1genome_0971

SAZO:

D1868_01445

CSTY:

KN1_17880

STEP:

IC006_1260

SMET:

RQ359_000646

SAHS:

HS7_19950

PAI:

PAE0660

PIS:

Pisl_0708

PCL:

Pcal_2086

PAS:

Pars_2316

PYR:

P186_2173

POG:

Pogu_2549

TNE:

Tneu_1958

PYW:	PYWP30_02210

CMA:

Cmaq_0732

TTN:

TTX_1683

TUZ:

TUZN_1828

VDI:

Vdis_0355

VMO:

VMUT_1277

VSO:	Vsou_16970

TPE:

Tpen_0433

THB:	N186_03185

TCB:	TCARB_1702

THF:	MA03_07865

THEL:

IG193_05470

ASC:

ASAC_1228

ACIA:

SE86_07310

CLG:	Calag_1169

FFO:	FFONT_1088

CSU:	CSUB_C0502

KCR:

Kcr_1437

BARC:

AOA65_2317

MARH:

Mia14_0125

FLT:	Sv326_0532

MIY:	Micr_00207

LOKI:

Lokiarch_20290 Lokiarch_25840

LOB:	NEF87_000385 NEF87_002412

PSYT:

DSAG12_00452 DSAG12_02845

AGW:	QT03_C0001G0925

» show all

Reference

1 [PMID:10960477]

Authors

Morii H, Nishihara M, Koga Y

Title

CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus.

Journal

J Biol Chem 275:36568-74 (2000)
DOI:10.1074/jbc.M005925200

Reference

2 [PMID:12562787]

Authors

Morii H, Koga Y

Title

CDP-2,3-Di-O-geranylgeranyl-sn-glycerol:L-serine O-archaetidyltransferase (archaetidylserine synthase) in the methanogenic archaeon Methanothermobacter thermautotrophicus.

Journal

J Bacteriol 185:1181-9 (2003)
DOI:10.1128/JB.185.4.1181-1189.2003

Reference

3 [PMID:25219966]

Authors

Jain S, Caforio A, Fodran P, Lolkema JS, Minnaard AJ, Driessen AJ

Title

Identification of CDP-archaeol synthase, a missing link of ether lipid biosynthesis in Archaea.

Journal

Chem Biol 21:1392-401 (2014)
DOI:10.1016/j.chembiol.2014.07.022

Sequence

[afu:AF_1740]