KEGG   ENZYME: 2.8.1.3
Entry
EC 2.8.1.3                  Enzyme                                 
Name
thiosulfate---thiol sulfurtransferase;
glutathione-dependent thiosulfate reductase;
sulfane reductase;
sulfane sulfurtransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
Sysname
thiosulfate:thiol sulfurtransferase
Reaction(IUBMB)
thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide [RN:R01875]
Reaction(KEGG)
R01875
Substrate
thiosulfate [CPD:C00320];
glutathione [CPD:C00051]
Product
sulfite [CPD:C00094];
glutathione disulfide [CPD:C00127];
sulfide [CPD:C00283]
Comment
The primary product is glutathione hydrodisulfide, which reacts with glutathione to give glutathione disulfide and sulfide. L-Cysteine can also act as acceptor.
History
EC 2.8.1.3 created 1982
Pathway
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:14484816]
  Authors
PECK HD Jr, FISHER E Jr.
  Title
The oxidation of thiosulfate and phosphorylation in extracts of Thiobacillus thioparus.
  Journal
J Biol Chem 237:190-7 (1962)
Reference
2
  Authors
Sido, B. and Koj, A.
  Title
Separation of rhodanese and thiosulfate reductase activities in carp liver extracts.
  Journal
Acta Biol Cracow Ser Zoo 15:97-103 (1972)
Reference
3  [PMID:383018]
  Authors
Uhteg LC, Westley J.
  Title
Purification and steady-state kinetic analysis of yeast thiosulfate reductase.
  Journal
Arch Biochem Biophys 195:211-22 (1979)
DOI:10.1016/0003-9861(79)90343-6
Other DBs
ExplorEnz - The Enzyme Database: 2.8.1.3
IUBMB Enzyme Nomenclature: 2.8.1.3
ExPASy - ENZYME nomenclature database: 2.8.1.3
BRENDA, the Enzyme Database: 2.8.1.3
CAS: 111070-24-7
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