KEGG   ENZYME: 2.8.3.17
Entry
EC 2.8.3.17                 Enzyme                                 
Name
3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase;
FldA;
cinnamoyl-CoA:phenyllactate CoA-transferase
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
Sysname
3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase
Reaction(IUBMB)
(1) (E)-cinnamoyl-CoA + (R)-(phenyl)lactate = (E)-cinnamate + (R)-(phenyl)lactoyl-CoA [RN:R07796];
(2) (E)-4-coumaroyl-CoA + (R)-3-(4-hydroxyphenyl)lactate = 4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA [RN:R12492];
(3) 3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate = 3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA [RN:R12493]
Reaction(KEGG)
R07796 R12492 R12493
Substrate
(E)-cinnamoyl-CoA [CPD:C16256];
(R)-(phenyl)lactate;
(E)-4-coumaroyl-CoA [CPD:C00223];
(R)-3-(4-hydroxyphenyl)lactate [CPD:C03964];
3-(indol-3-yl)acryloyl-CoA [CPD:C22207];
(R)-3-(indol-3-yl)lactate [CPD:C22006]
Product
(E)-cinnamate [CPD:C00423];
(R)-(phenyl)lactoyl-CoA;
4-coumarate [CPD:C00811];
(R)-3-(4-hydroxyphenyl)lactoyl-CoA [CPD:C22205];
3-(indol-3-yl)acrylate [CPD:C21283];
(R)-3-(indol-3-yl)lactoyl-CoA [CPD:C22206]
Comment
The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. It forms a complex with EC 4.2.1.175, (R)-3-(aryl)lactoyl-CoA dehydratase.
History
EC 2.8.3.17 created 2003, modified 2019
Pathway
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K13607  cinnamoyl-CoA:phenyllactate CoA-transferase
Genes
SYM: K6K13_14550
PCOL: F1325_16665
PPEE: I6G31_11940
CBO: CBO3292(fldA)
CBA: CLB_3348(fldA)
CBH: CLC_3234(fldA)
CBY: CLM_3725(fldA)
CBL: CLK_2708(fldA)
CBB: CLD_1231(fldA)
CBI: CLJ_B3572(fldA)
CBF: CLI_3462(fldA)
CBM: CBF_3444(fldA)
CBJ: H04402_03377
CLD: CLSPO_c34120(fldA)
CFER: D4Z93_06645
CCAA: KQH81_14360
CFEM: HCR03_03830
LGG: QJR73_06875
MNL: QU661_02670
PEB: O0R46_02445
PIV: NCTC13079_00074(frc)
 » show all
Reference
1  [PMID:10849007]
  Authors
Dickert S, Pierik AJ, Linder D, Buckel W
  Title
The involvement of coenzyme A esters in the dehydration of (R)-phenyllactate to (E)-cinnamate by Clostridium sporogenes.
  Journal
Eur J Biochem 267:3874-84 (2000)
DOI:10.1046/j.1432-1327.2000.01427.x
  Sequence
[ag:AAL18808]
Reference
2  [PMID:29168502]
  Authors
Dodd D, Spitzer MH, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL
  Title
A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites.
  Journal
Nature 551:648-652 (2017)
DOI:10.1038/nature24661
Other DBs
ExplorEnz - The Enzyme Database: 2.8.3.17
IUBMB Enzyme Nomenclature: 2.8.3.17
ExPASy - ENZYME nomenclature database: 2.8.3.17
BRENDA, the Enzyme Database: 2.8.3.17
CAS: 289682-21-9
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