KEGG   ENZYME: 3.1.1.59
Entry
EC 3.1.1.59                 Enzyme                                 
Name
juvenile-hormone esterase;
JH-esterase;
juvenile hormone analog esterase;
juvenile hormone carboxyesterase;
methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
methyl-(2E,6E,10R)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase
Reaction(IUBMB)
(1) juvenile hormone I + H2O = juvenile hormone I acid + methanol [RN:R10983];
(2) juvenile hormone III + H2O = juvenile hormone III acid + methanol [RN:R08149]
Reaction(KEGG)
R08149 R10983;
(other) R04608 R08150
Substrate
juvenile hormone I [CPD:C19613];
H2O [CPD:C00001];
juvenile hormone III [CPD:C09694]
Product
juvenile hormone I acid [CPD:C20992];
methanol [CPD:C00132];
juvenile hormone III acid [CPD:C16504]
Comment
Demethylates the insect juvenile hormones JH1 and JH3, but does not hydrolyse the analogous ethyl or isopropyl esters.
History
EC 3.1.1.59 created 1989, modified 2015
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K01063  juvenile-hormone esterase
Genes
DMEDmel_CG8425(Jhe)
DER113564355 6548853
DSE6609376
DSIDsimw501_GD11160(Dsim_GD11160) Dsimw501_GD11161(Dsim_GD11161)
DYADyak_GE11753
DAN6494157
DSR110188938
DPO6899082
DPE6601344 6601345
DMN108158080 108160294 108160295
DWI124460021 26529390 26529636 26529934 6640104 6640209 6640210 6640211 6640534 6640538 6642291 6642292 6652305
DGR6560824
DMODmoj_GI19153 Dmoj_GI19154
DAZ108614905
DNV108652754
DHE111594015 111594041
DVI116650991
CCAT101455422 101455709 101459506(Jhedup2)
BDR125775307
RZE108366603
AOQ129243757 129243759
TDA119679320 119681516 119685708
MDE101898361
SCAC106095748 106095759 106096357 106096366
LCQ111684795 111684803 111689842 111689844 111689880
LSQ119614830 119614831 119614832 119614893 119615303
GFS119636606
ECOE129951017
CLON129607568
HIS119659715
AGA1276501 4576394 4576396 4576397
ACOZ120947906 120947907 120952446 120953460 120961449
AARA120895609 120895877 120895878 120895976 120895977
AMER121591702 121592357 121592358 121593649 121594183 121594184 121594372
ASTE118511476 118511478
AFUN125769211 125770360 125770361
AMOU128303069 128303071
AALI118467970 118467972
AAG5564561 5566107 5566114 5566115 5566144
AALB109409689 109409690 109409691 109409692
CQUCpipJ_CPIJ002073 CpipJ_CPIJ002074 CpipJ_CPIJ002075 CpipJ_CPIJ007135 CpipJ_CPIJ007140 CpipJ_CPIJ013026 CpipJ_CPIJ013027 CpipJ_CPIJ013028 CpipJ_CPIJ013029 CpipJ_CPIJ013175 CpipJ_CPIJ014154 CpipJ_CPIJ020045
CPII120415174 120421623 120424078 120424082 120424083 120428123 120428686 120430980 120430983 128093046 128093053
CNS116339894 116343186 116345269 116346537
BCOO119067276 119073846 119081748 119083194
ACER107994233 107998239
ALAB122712419
ADR102672496
AFLR100865786 100872445 116413875
BBIF117207348 117215610
BVK117239627 117239629
BVAN117160201 117165772 117165823
BAFF126916694 126916695 126916696
BPYO122565904 122565905
BPAS132905321 132905322 132914427
FVI122538242
OLG117605442
MGEN117223177
NMEA116430565 116430566
CGIG122398420 122398537
SOC105204452
ACEP105624427
CFO105253145
FEX115244260 115244603
PFUC122521421 122526321
VPS122626934
VCRB124428671
TPRE106648476 106648477 106648642 106649960 106651086 106654859
CGLO123264594 123265768
FAS105268394 105268604 105271909 105272368
DAM107036668 107037809 107037811 107037825 107041165 107044435
AGIF122849067 122852485 122857263
VCAN122409331 122418994
CCIN107268776 107270792
DSM124407039 124407637 124409783 124410412 124410413 124410414 124410415 124410416 124410419 124410422 124410522 124410523 124410524 124410525 124416654 124416721
NPT124210651 124212731 124214444 124214796 124218439 124218440 124218444 124219904 124219921 124220017
NFB124175828 124176639 124178099 124178327 124182254 124182256 124182257 124182258 124182260 124183288 124183541 124188061
NLO107219295 107221013 107221179 107222874 107224671 107224675 107224680 107225623 124292844 124293469 124294379 124296566
NVG124297689 124299274 124299661 124299662 124300638 124304606 124304608 124304609 124304612 124304615 124305757 124306490 124310056
AROA105690567 105691706
TCA658208(Tcjhe)
DPA109544202
SOY115874432 115880324
AGRG126735652 126742870
ATD109604357 109604377
CSET123320239
AGB108914511 108914512 108917334 108917359 108917459 108917768 111692882
LDC111503335 111503338 111509916
NVL108559512 108567338
APLN108736917 108739450 108739452 108739470 108739568 108739585
PPYR116162493 116166887 116167223 116170992 116174771 116174863 116174864 116175126 116177944 116179631
OTU111413493 111427441
MJU123875984
LSIN126977948
HAW110380678
CFEL113368432
API100167473
DNX107163695
AGS114125584
RMD113560686 113560695 113560932
ACOO126838497
DVT126900232 126900235 126904457 126910303
BTAB109044387
HHAL106678779 106678781 106684895 106684907 106691387
NLU111060276
HVI124366927 124367584
MQU128982378 128982379 128995358 128995863 129002324 129002481
FOC113204778 113216791
TPAL117639564 117643349 117651814 117652006 117653369
ZNE110830303
CSEC111861666 111862711 111868484 111871333 111871335
SGRE126282181
IEL124163490
DMK116931876
PCHN125027212 125027534 125033407 125038500
PCLA123755654
CQD128687322 128693473 128698083
PTRU123500966 123503046 123514018 123514097 123514098 123514181
ESN126980321 126985047
HAZT108676749
LSM121123268 121125935
TCF131880174
PPOI119089278 119089382 119089461 119090585 119090667 119092189 119094471 119099705 119099707 119099708 119100042 119100043 119100047 119100048 119100049 119100050 119100051 119100052 119101124 119101382 119101651 119101665 119101794 119101795 119102518 119103911 119104892 119112110 119112220 119114728
DSV119441975
RSAN119387580
VDE111247698
VJA111273776
DFR124498270
UDV129219351
HRJ124285713
 » show all
Reference
1
  Authors
de Kort, C.A.D. and Granger, N.A.
  Title
Regulation of the juvenile hormone titer.
  Journal
Annu Rev Entomol 26:1-28 (1981)
Reference
2
  Authors
Mitsui, T., Riddiford, L.M. and Bellamy, G.
  Title
Metabolism of juvenile hormone by the epidermis of the tobacco hornworm (Manduca sexta).
  Journal
Insect Biochem 9:637-643 (1979)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.59
IUBMB Enzyme Nomenclature: 3.1.1.59
ExPASy - ENZYME nomenclature database: 3.1.1.59
BRENDA, the Enzyme Database: 3.1.1.59
CAS: 50812-15-2
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